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6MB3
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CRYO-EM STRUCTURE OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM FALCIPARUM WITH A VACCINE-ELICITED ANTIBODY REVEALS MATURATION OF INTER-ANTIBODY CONTACTS
Descriptor:Plasmodium falciparum recombinant shortened CSP, Fab311 heavy chain, Fab311 light chain
Authors:Cottrell, C.A., Torres, J.L., Ward, A.B.
Deposit date:2018-08-29
Release date:2018-10-31
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.
Sci Adv, 4, 2018
6MHG
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CRYO-EM STRUCTURE OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM FALCIPARUM WITH A VACCINE-ELICITED ANTIBODY REVEALS MATURATION OF INTER-ANTIBODY CONTACTS
Descriptor:circumsporozoite protein, Fab311 heavy chain, Fab311 light chain
Authors:Cottrell, C.A., Torres, J.L., Ward, A.B.
Deposit date:2018-09-17
Release date:2018-10-31
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Cryo-EM structure ofP. falciparumcircumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts.
Sci Adv, 4, 2018
6NC2
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AMC011 V4.2 SOSIP ENV TRIMER IN COMPLEX WITH FUSION PEPTIDE TARGETING ANTIBODY ACS202 FRAGMENT ANTIGEN BINDING
Descriptor:AMC011 v4.2 SOSIP gp120, AMC011 v4.2 SOSIP gp41, Monoclonal antibody ACS202 fragment antigen binding heavy chain, ...
Authors:Cottrell, C.A., Ozorowski, G., Yuan, M., Copps, J., Wilson, I.A., Ward, A.B.
Deposit date:2018-12-10
Release date:2019-06-19
Last modified:2019-06-26
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Cell Host Microbe, 25, 2019
6NC3
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AMC011 V4.2 SOSIP ENV TRIMER IN COMPLEX WITH FUSION PEPTIDE TARGETING ANTIBODY VRC34 FRAGMENT ANTIGEN BINDING
Descriptor:HIV-1 Env AMC011 v4.2 SOSIP gp120, HIV-1 Env AMC011 v4.2 SOSIP gp41, Monoclonal antibody VRC34.01 fragment antigen binding heavy chain, ...
Authors:Cottrell, C.A., Ozorowski, G., Torres, J.L., Ward, A.B.
Deposit date:2018-12-10
Release date:2019-06-19
Last modified:2019-06-26
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Cell Host Microbe, 25, 2019
5I08
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PREFUSION STRUCTURE OF A HUMAN CORONAVIRUS SPIKE PROTEIN
Descriptor:Spike glycoprotein, envelope glycoprotein chimera
Authors:Kirchdoerfer, R.N., Cottrell, C.A., Wang, N., Pallesen, J., Yassine, H.M., Turner, H.L., Corbett, K.S., Graham, B.S., McLellan, J.S., Ward, A.B.
Deposit date:2016-02-03
Release date:2016-03-02
Last modified:2016-04-13
Method:ELECTRON MICROSCOPY (4.04 Å)
Cite:Pre-fusion structure of a human coronavirus spike protein.
Nature, 531, 2016
5KEL
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EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C2G4 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEM
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EBOV SGP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C13C6 AND BDBV91
Descriptor:BDBV91 variable Fab domain light chain, BDBV91 variable Fab domain heavy chain, c13C6 variable Fab domain heavy chain, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5KEN
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EBOV GP IN COMPLEX WITH VARIABLE FAB DOMAINS OF IGGS C4G7 AND C13C6
Descriptor:Ebola surface glycoprotein, GP1, GP2, ...
Authors:Pallesen, J., Murin, C.D., de Val, N., Cottrell, C.A., Hastie, K.M., Turner, H.L., Fusco, M.L., Flyak, A.I., Zeitlin, L., Crowe Jr., J.E., Andersen, K.G., Saphire, E.O., Ward, A.B.
Deposit date:2016-06-09
Release date:2016-09-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structures of Ebola virus GP and sGP in complex with therapeutic antibodies.
Nat Microbiol, 1, 2016
5V8M
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BG505 SOSIP.664 TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING HIV ANTIBODY 3BNC117
Descriptor:gp120, gp41, antibody 3BNC117, ...
Authors:Lee, J.H., Cottrell, C.A., Ward, A.B.
Deposit date:2017-03-22
Release date:2017-05-03
Last modified:2017-07-26
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
5VN8
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CRYO-EM MODEL OF B41 SOSIP.664 IN COMPLEX WITH FRAGMENT ANTIGEN BINDING VARIABLE DOMAIN OF B12
Descriptor:Envelope glycoprotein gp160, b12 Fab heavy chain, b12 Fab light chain, ...
Authors:Ozorowski, G., Pallesen, J., Ward, A.B., Cottrell, C.A.
Deposit date:2017-04-28
Release date:2017-07-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.
Nature, 547, 2017
6CRV
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SARS SPIKE GLYCOPROTEIN, STABILIZED VARIANT, C3 SYMMETRY
Descriptor:Spike glycoprotein,Fibritin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Kirchdoerfer, R.N., Wang, N., Pallesen, J., Turner, H.L., Cottrell, C.A., McLellan, J.S., Ward, A.B.
Deposit date:2018-03-19
Release date:2018-04-11
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6CRW
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SARS SPIKE GLYCOPROTEIN, STABILIZED VARIANT, SINGLE UPWARDS S1 CTD CONFORMATION
Descriptor:Spike glycoprotein,Fibritin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kirchdoerfer, R.N., Wang, N., Pallesen, J., Turner, H.L., Cottrell, C.A., McLellan, J.S., Ward, A.B.
Deposit date:2018-03-19
Release date:2018-04-11
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6CRX
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SARS SPIKE GLYCOPROTEIN, STABILIZED VARIANT, TWO S1 CTDS IN THE UPWARDS CONFORMATION
Descriptor:Spike glycoprotein,Fibritin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kirchdoerfer, R.N., Wang, N., Pallesen, J., Turner, H.L., Cottrell, C.A., McLellan, J.S., Ward, A.B.
Deposit date:2018-03-19
Release date:2018-04-11
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6CRZ
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SARS SPIKE GLYCOPROTEIN, TRYPSIN-CLEAVED, STABILIZED VARIANT, C3 SYMMETRY
Descriptor:Spike glycoprotein,Fibritin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kirchdoerfer, R.N., Wang, N., Pallesen, J., Turner, H.L., Cottrell, C.A., McLellan, J.S., Ward, A.B.
Deposit date:2018-03-19
Release date:2018-04-11
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6CS0
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SARS SPIKE GLYCOPROTEIN, TRYPSIN-CLEAVED, STABILIZED VARIANT, ONE S1 CTD IN AN UPWARDS CONFORMATION
Descriptor:Spike glycoprotein,Fibritin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kirchdoerfer, R.N., Wang, N., Pallesen, J., Turner, H.L., Cottrell, C.A., McLellan, J.S., Ward, A.B.
Deposit date:2018-03-19
Release date:2018-04-11
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6CS1
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SARS SPIKE GLYCOPROTEIN, TRYPSIN-CLEAVED, STABILIZED VARIANT, TWO S1 CTDS IN AN UPWARDS CONFORMATION
Descriptor:Spike glycoprotein,Fibritin, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kirchdoerfer, R.N., Wang, N., Pallesen, J., Turner, H.L., Cottrell, C.A., McLellan, J.S., Ward, A.B.
Deposit date:2018-03-19
Release date:2018-04-11
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6CS2
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SARS SPIKE GLYCOPROTEIN - HUMAN ACE2 COMPLEX, STABILIZED VARIANT, ALL ACE2-BOUND PARTICLES
Descriptor:Spike glycoprotein,Fibritin, Angiotensin-converting enzyme 2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kirchdoerfer, R.N., Wang, N., Pallesen, J., Turner, H.L., Cottrell, C.A., McLellan, J.S., Ward, A.B.
Deposit date:2018-03-19
Release date:2018-04-11
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis.
Sci Rep, 8, 2018
6DID
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HIV ENV BG505 SOSIP WITH POLYCLONAL FABS FROM IMMUNIZED RABBIT #3417 POST-BOOST#1
Descriptor:Envelope glycoprotein gp160, Monoclonal antibody 10A light chain, Monoclonal antibody 10A heavy chain, ...
Authors:Turner, H.L., Cottrell, C.A., Oyen, D., Wilson, I.A., Ward, A.B.
Deposit date:2018-05-23
Release date:2018-09-05
Method:ELECTRON MICROSCOPY (4.71 Å)
Cite:Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization.
Immunity, 49, 2018
6DJB
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STRUCTURE OF HUMAN VOLUME REGULATED ANION CHANNEL COMPOSED OF SWELL1 (LRRC8A)
Descriptor:Volume-regulated anion channel subunit LRRC8A
Authors:Kefauver, J.M., Saotome, K., Pallesen, J., Cottrell, C.A., Ward, A.B., Patapoutian, A.
Deposit date:2018-05-24
Release date:2018-08-15
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structure of the human volume regulated anion channel.
Elife, 7, 2018
6MLM
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H7 HA0 IN COMPLEX WITH FV FROM H7.5 IGG
Descriptor:Hemagglutinin HA1 chain, Hemagglutinin HA2 chain, Heavy chain Fv of H7.5 Fab, ...
Authors:Pallesen, J., Turner, H.L., Ward, A.B.
Deposit date:2018-09-27
Release date:2019-02-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.
PLoS Biol., 17, 2019
5UY3
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CRYSTAL STRUCTURE OF HUMAN FAB PGT144, A BROADLY REACTIVE AND POTENT HIV-1 NEUTRALIZING ANTIBODY
Descriptor:Antibody PGT144 Fab light chain, Antibody PGT144 Fab heavy chain
Authors:Julien, J.-P., Lee, J.H., Wilson, I.A.
Deposit date:2017-02-23
Release date:2017-04-19
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
5V8L
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BG505 SOSIP.664 TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING HIV ANTIBODIES 3BNC117 AND PGT145
Descriptor:gp120, gp41, 3BNC117 antibody, ...
Authors:Lee, J.H., Ward, A.B.
Deposit date:2017-03-22
Release date:2017-05-03
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
5VN3
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CRYO-EM MODEL OF B41 SOSIP.664 IN COMPLEX WITH SOLUBLE CD4 (D1-D2) AND FRAGMENT ANTIGEN BINDING VARIABLE DOMAIN OF 17B
Descriptor:17b Fab light chain, Envelope glycoprotein gp160, T-cell surface glycoprotein CD4, ...
Authors:Ozorowski, G., Pallesen, J., Ward, A.B.
Deposit date:2017-04-28
Release date:2017-07-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.
Nature, 547, 2017
5VYH
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CRYSTAL STRUCTURE OF MERS-COV S1 N-TERMINAL DOMAIN
Descriptor:S protein, N-ACETYL-D-GLUCOSAMINE, FOLIC ACID, ...
Authors:Wang, N., Wrapp, D., Pallesen, J., Ward, A.B., McLellan, J.S.
Deposit date:2017-05-25
Release date:2017-08-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5VZR
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CRYSTAL STRUCTURE OF MERS-COV NEUTRALIZING ANTIBODY G4 FAB
Descriptor:G4 antibody heavy chain, G4 antibody light chain, GLYCEROL
Authors:Wang, N., Wrapp, D., McLellan, J.S.
Deposit date:2017-05-29
Release date:2017-08-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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