Author results

1DT6
  • Download 1dt6
  • View 1dt6
Molmil generated image of 1dt6
STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5
分子名称:CYTOCHROME P450 2C5, SAMARIUM (III) ION, SULFATE ION, ...
著者Williams, P.A., Cosme, J., Sridhar, V., Johnson, E.F., McRee, D.E.
登録日2000-01-11
公開日2000-09-27
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.
Mol.Cell, 5, 2000
1OG2
  • Download 1og2
  • View 1og2
Molmil generated image of 1og2
STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9
分子名称:CYTOCHROME P450 2C9, HEME C
著者Williams, P.A., Cosme, J., Ward, A., Angove, H.C., Matak Vinkovic, D., Jhoti, H.
登録日2003-04-23
公開日2003-07-17
最終更新日2011-11-09
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin
Nature, 424, 2003
1OG5
  • Download 1og5
  • View 1og5
Molmil generated image of 1og5
STRUCTURE OF HUMAN CYTOCHROME P450 CYP2C9
分子名称:CYTOCHROME P450 2C9, HEME C, S-WARFARIN
著者Williams, P.A., Cosme, J., Ward, A., Angove, H.C., Matak Vinkovic, D., Jhoti, H.
登録日2003-04-24
公開日2003-07-17
最終更新日2011-11-09
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin
Nature, 424, 2003
1W0E
  • Download 1w0e
  • View 1w0e
Molmil generated image of 1w0e
CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4
分子名称:CYTOCHROME P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
著者Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.
登録日2004-06-03
公開日2004-07-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
Science, 305, 2004
1W0F
  • Download 1w0f
  • View 1w0f
Molmil generated image of 1w0f
CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4
分子名称:CYTOCHROME P450 3A4, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE
著者Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.
登録日2004-06-03
公開日2004-07-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
Science, 305, 2004
1W0G
  • Download 1w0g
  • View 1w0g
Molmil generated image of 1w0g
CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 3A4
分子名称:CYTOCHROME P450 3A4, METYRAPONE, PROTOPORPHYRIN IX CONTAINING FE
著者Williams, P.A., Cosme, J., Vinkovic, D.M., Ward, A., Angove, H.C., Day, P.J., Vonrhein, C., Tickle, I.J., Jhoti, H.
登録日2004-06-03
公開日2004-07-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone
Science, 305, 2004
2XAB
  • Download 2xab
  • View 2xab
Molmil generated image of 2xab
STRUCTURE OF HSP90 WITH AN INHIBITOR BOUND
分子名称:HEAT SHOCK PROTEIN HSP 90-ALPHA,, 4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)-6-(1-METHYLETHYL)BENZENE-1,3-DIOL
著者Murray, C.W., Carr, M.G., Callaghan, O., Chessari, G., Congreve, m., Cowan, S., Coyle, J.E., Downham, R., Figueroa, E., Frederickson, M., Graham, B., McMenamin, R., O'Brian, M.A., Patel, S., Phillips, T.R., Williams, G., Woodhead, A.J., Woolford, A.J.A.
登録日2010-03-30
公開日2010-08-11
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]Methanone (at13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design.
J.Med.Chem., 53, 2010
2XJG
  • Download 2xjg
  • View 2xjg
Molmil generated image of 2xjg
STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
分子名称:HEAT SHOCK PROTEIN HSP 90-ALPHA, 1,3-DIHYDROISOINDOL-2-YL-(2-HYDROXY-4-METHOXY-5-PROPAN-2-YL-PHENYL)METHANONE
著者Murray, C.W., Carr, M.G., Callaghan, O., Chessari, G., Congreve, M., Cowan, S., Coyle, J.E., Downham, R., Figueroa, E., Frederickson, M., Graham, B., McMenamin, R., OBrien, M.A., Patel, S., Phillips, T.R., Williams, B., Woodhead, A.J., Woolford, A.J.A.
登録日2010-07-06
公開日2010-08-11
最終更新日2015-04-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]Methanone (at13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design.
J.Med.Chem., 53, 2010
2XJJ
  • Download 2xjj
  • View 2xjj
Molmil generated image of 2xjj
STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
分子名称:HEAT SHOCK PROTEIN HSP 90-ALPHA, GLYCEROL, 1,3-DIHYDROISOINDOL-2-YL-(6-HYDROXY-3,3-DIMETHYL-1,2-DIHYDROINDOL-5-YL)METHANONE
著者Murray, C.W., Carr, M.G., Callaghan, O., Chessari, G., Congreve, M., Cowan, S., Coyle, J.E., Downham, R., Figueroa, E., Frederickson, M., Graham, B., McMenamin, R., OBrien, M.A., Patel, S., Phillips, T.R., Williams, G., Woodhead, A.J., Woolford, A.J.A.
登録日2010-07-06
公開日2010-08-11
最終更新日2015-04-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]Methanone (at13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design.
J.Med.Chem., 53, 2010
2XJX
  • Download 2xjx
  • View 2xjx
Molmil generated image of 2xjx
STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND
分子名称:HEAT SHOCK PROTEIN HSP 90-ALPHA, Onalespib
著者Murray, C.W., Carr, M.G., Callaghan, O., Chessari, G., Congreve, M., Cowan, S., Coyle, J.E., Downham, R., Figueroa, E., Frederickson, M., Graham, B., McMenamin, R., OBrien, M.A., Patel, S., Phillips, T.R., Williams, G., Woodhead, A.J., Woolford, A.J.A.
登録日2010-07-06
公開日2010-08-11
最終更新日2015-02-18
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Discovery of (2,4-Dihydroxy-5-Isopropylphenyl)-[5-(4-Methylpiperazin-1-Ylmethyl)-1,3-Dihydroisoindol-2-Yl]Methanone (at13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design.
J.Med.Chem., 53, 2010
1N6B
  • Download 1n6b
  • View 1n6b
Molmil generated image of 1n6b
MICROSOMAL CYTOCHROME P450 2C5/3LVDH COMPLEX WITH A DIMETHYL DERIVATIVE OF SULFAPHENAZOLE
分子名称:Cytochrome P450 2C5, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Wester, M.R., Johnson, E.F., Marques-Soares, C., Dansette, P.M., Mansuy, D., Stout, C.D.
登録日2002-11-09
公開日2003-06-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of a Substrate Complex of Mammalian Cytochrome P450 2C5 at 2.3 A Resolution: Evidence for Multiple Substrate Binding Modes
Biochemistry, 42, 2003
4ECL
  • Download 4ecl
  • View 4ecl
Molmil generated image of 4ecl
CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF VANCOMYCIN RESISTANCE SERINE RACEMASE VANTG
分子名称:Serine racemase, CHLORIDE ION, SULFATE ION
著者Stogios, P.J., Wawrzak, Z., Minasov, G., Evdokimova, E., Egorova, O., Cosme, J., Di Leo, R., Krishnamoorthy, M., Meziane-Cherif, D., Courvalin, P., Savchenko, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-03-26
公開日2012-04-18
最終更新日2016-06-01
実験手法X-RAY DIFFRACTION (2.017 Å)
主引用文献Structural and Functional Adaptation of Vancomycin Resistance VanT Serine Racemases.
MBio, 6, 2015