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1F6G
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BU of 1f6g by Molmil
POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD
Descriptor: VOLTAGE-GATED POTASSIUM CHANNEL
Authors:Cortes, D.M, Perozo, E.
Deposit date:2000-06-21
Release date:2001-02-21
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating.
J.Gen.Physiol., 117, 2001
3HPL
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BU of 3hpl by Molmil
KcsA E71H-F103A mutant in the closed state
Descriptor: Antibody Fab heavy chain, Antibody fab light chain, POTASSIUM ION, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2009-06-04
Release date:2010-06-23
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for the coupling between activation and inactivation gates in K(+) channels.
Nature, 466, 2010
6BY3
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BU of 6by3 by Molmil
Open and conductive conformation of KcsA-T75A mutant
Descriptor: Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ...
Authors:Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G.
Deposit date:2017-12-19
Release date:2018-05-09
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Inverted allosteric coupling between activation and inactivation gates in K+channels.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6BY2
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BU of 6by2 by Molmil
Closed and deep-inactivated conformation of KcsA-T75A mutant
Descriptor: Antibody Heavy Chain, Antibody Light Chain, DIACYL GLYCEROL, ...
Authors:Labro, A.J, Cortes, D.M, Tilegenova, C, Cuello, L.G.
Deposit date:2017-12-19
Release date:2018-05-09
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Inverted allosteric coupling between activation and inactivation gates in K+channels.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3OR7
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BU of 3or7 by Molmil
On the structural basis of modal gating behavior in K+channels - E71I
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Pan, A.C, Cortes, D.M, Roux, B, Perozo, E.
Deposit date:2010-09-06
Release date:2011-01-05
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:On the structural basis of modal gating behavior in K(+) channels.
Nat.Struct.Mol.Biol., 18, 2011
6NFV
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BU of 6nfv by Molmil
Structure of the KcsA-G77C mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ...
Authors:Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G.
Deposit date:2018-12-20
Release date:2019-08-07
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
6NFU
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BU of 6nfu by Molmil
Structure of the KcsA-G77A mutant or the 2,4-ion bound configuration of a K+ channel selectivity filter.
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, NONAN-1-OL, POTASSIUM ION, ...
Authors:Tilegenova, C, Cortes, D.M, Jahovic, N, Hardy, E, Parameswaran, H, Guan, L, Cuello, L.G.
Deposit date:2018-12-20
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
3FB5
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BU of 3fb5 by Molmil
KcsA potassium channel in the partially open state with 14.5 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-18
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:KcsA potassium channel in the partially open state with 14.5 A opening at T112
TO BE PUBLISHED
3FB6
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BU of 3fb6 by Molmil
KcsA Potassium channel in the partially open state with 16 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-18
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:KcsA Potassium channel in the partially open state with 16 A opening at T112
TO BE PUBLISHED
3FB7
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BU of 3fb7 by Molmil
Open KcsA potassium channel in the presence of Rb+ ion
Descriptor: RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Pan, A.C, Gagnon, D.H, Cordero-Morales, J.F, Chakrapani, S, Roux, B, Perozo, E.
Deposit date:2008-11-18
Release date:2010-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Open KcsA potassium channel in the presence of Rb+ ion
TO BE PUBLISHED
3F7Y
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BU of 3f7y by Molmil
KcsA Potassium channel in the partially open state with 17 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-10
Release date:2010-05-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:KcsA Potassium channel in the partially open state with 17 A opening at T112
TO BE PUBLISHED
3F5W
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BU of 3f5w by Molmil
KcsA Potassium channel in the open-inactivated state with 32 A opening at T112
Descriptor: Antibody heavy chain, Antibody light chain, POTASSIUM ION, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-04
Release date:2010-05-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:KcsA Potassium channel in the open-inactivated state with 32 A opening at T112
TO BE PUBLISHED
3FB8
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BU of 3fb8 by Molmil
KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion
Descriptor: RUBIDIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-18
Release date:2010-05-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:KcsA Potassium channel in the open-conductive state with 20 A opening at T112 in the presence of Rb+ ion
TO BE PUBLISHED
3F7V
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BU of 3f7v by Molmil
KcsA Potassium channel in the open-inactivated state with 23 A opening at T112
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment Heavy chain, ...
Authors:Cuello, L.G, Jogini, V, Cortes, D.M, Perozo, E.
Deposit date:2008-11-10
Release date:2010-05-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:KcsA Potassium channel in the open-inactivated state with 23 A opening at T112
TO BE PUBLISHED
1ZWI
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BU of 1zwi by Molmil
Structure of mutant KcsA potassium channel
Descriptor: DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ...
Authors:Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Cortes, D.M, Roux, B, Perozo, E.
Deposit date:2005-06-03
Release date:2006-03-07
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular determinants of gating at the potassium-channel selectivity filter.
Nat.Struct.Mol.Biol., 13, 2006
2P7T
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BU of 2p7t by Molmil
Crystal Structure of KcsA mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB-A, FAB-B, ...
Authors:Cordero-Morales, J.F, Vishwanath, J, Lewis, A, Valeria, V.R, Cortes, D.M, Roux, B, Perozo, E.
Deposit date:2007-03-20
Release date:2007-10-09
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of KcsA mutant
To be Published
5VKH
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BU of 5vkh by Molmil
Closed conformation of KcsA Y82A-F103A mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E, Cortes, D.M.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
5VKE
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BU of 5vke by Molmil
Open conformation of KcsA deep-inactivated
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E, Cortes, D.M.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
7SQW
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BU of 7sqw by Molmil
Structure of the KcsA-W67F mutant with the activation gate in the closed conformation
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Fragment, KcsA potassium channel, ...
Authors:Cuello, L.G, Labro, A.J.
Deposit date:2021-11-07
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels.
Sci Adv, 8, 2022
6PA0
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BU of 6pa0 by Molmil
Structure of the G77A mutant in Sodium Chloride
Descriptor: Antibody HEAVY fragment, Antibody LIGHT fragment, DIACYL GLYCEROL, ...
Authors:Cuello, L.G, Guan, L.
Deposit date:2019-06-11
Release date:2019-08-07
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure, function, and ion-binding properties of a K+channel stabilized in the 2,4-ion-bound configuration.
Proc.Natl.Acad.Sci.USA, 116, 2019
3OR6
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BU of 3or6 by Molmil
On the structural basis of modal gating behavior in K+channels - E71Q
Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ...
Authors:Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Perozo, E.
Deposit date:2010-09-06
Release date:2011-01-05
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:On the structural basis of modal gating behavior in K(+) channels.
Nat.Struct.Mol.Biol., 18, 2011
3PJS
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BU of 3pjs by Molmil
Mechanism of Activation Gating in the Full-Length KcsA K+ Channel
Descriptor: FAB heavy chain, FAB light chain, Voltage-gated potassium channel
Authors:Uysal, S, Cuello, L.G, Kossiakoff, A, Perozo, E.
Deposit date:2010-11-10
Release date:2011-07-06
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Mechanism of activation gating in the full-length KcsA K+ channel.
Proc.Natl.Acad.Sci.USA, 108, 2011
2ATK
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BU of 2atk by Molmil
Structure of a mutant KcsA K+ channel
Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, NONAN-1-OL, ...
Authors:Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Chakrapani, S, Roux, B, Perozo, E.
Deposit date:2005-08-25
Release date:2006-03-07
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular determinants of gating at the potassium-channel selectivity filter.
Nat.Struct.Mol.Biol., 13, 2006
5VK6
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BU of 5vk6 by Molmil
Open conformation of KcsA non-inactivating E71A mutant
Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Cuello, L.G, Perozo, E.
Deposit date:2017-04-21
Release date:2017-12-06
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The gating cycle of a K+ channel at atomic resolution.
Elife, 6, 2017
1JQ2
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BU of 1jq2 by Molmil
POTASSIUM CHANNEL (KCSA) OPEN GATE MODEL
Descriptor: VOLTAGE-GATED POTASSIUM CHANNEL
Authors:Liu, Y.-S, Sompornpisut, P, Perozo, E.
Deposit date:2001-08-03
Release date:2001-10-03
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:Structure of the KcsA channel intracellular gate in the open state.
Nat.Struct.Biol., 8, 2001

 

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