6IWB
| Crystal structure of a computationally designed protein (LD3) in complex with BCL-2 | Descriptor: | Apolipoprotein E, Apoptosis regulator Bcl-2,Apoptosis regulator Bcl-2, SULFATE ION | Authors: | Kim, S, Kwak, M.J, Oh, B.-H, Correia, B.E, Gainza, P. | Deposit date: | 2018-12-05 | Release date: | 2019-12-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy. Nat.Biotechnol., 38, 2020
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6XXV
| Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 | Descriptor: | Antibody C57, Heavy Chain, Light Chain, ... | Authors: | Yang, C, Sesterhenn, F, Correia, B.E, Pojer, F. | Deposit date: | 2020-01-28 | Release date: | 2020-04-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.20116425 Å) | Cite: | De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
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6YWC
| De novo designed protein 4E1H_95 in complex with 101F antibody | Descriptor: | Antibody 101F, Heavy Chain, light chain, ... | Authors: | Yang, C, Sesterhenn, F, Pojer, F, Correia, B.E. | Deposit date: | 2020-04-29 | Release date: | 2020-10-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Bottom-up de novo design of functional proteins with complex structural features. Nat.Chem.Biol., 17, 2021
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6YWD
| De novo designed protein 4H_01 in complex with Mota antibody | Descriptor: | Antibody Mota, Heavy Chain, Light Chain, ... | Authors: | Yang, C, Sesterhenn, F, Pojer, F, Correia, B.E. | Deposit date: | 2020-04-29 | Release date: | 2020-10-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Bottom-up de novo design of functional proteins with complex structural features. Nat.Chem.Biol., 17, 2021
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7AYE
| Crystal structure of the computationally designed chemically disruptable heterodimer LD6-MDM2 | Descriptor: | Isoform 11 of E3 ubiquitin-protein ligase Mdm2, Thiol:disulfide interchange protein DsbD | Authors: | Yang, C, Lau, K, Pojer, F, Correia, B.E. | Deposit date: | 2020-11-12 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | A rational blueprint for the design of chemically-controlled protein switches. Nat Commun, 12, 2021
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8Q70
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8P49
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8QHP
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8OYV
| De novo designed Claudin fold CLF_4 | Descriptor: | De novo designed soluble Claudin | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Computational design of soluble functional analogues of integral membrane proteins. Biorxiv, 2024
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8OYX
| De novo designed soluble GPCR-like fold GLF_18 | Descriptor: | De novo designed soluble GPCR-like protein, PHOSPHATE ION | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Computational design of soluble functional analogues of integral membrane proteins. Biorxiv, 2024
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8OYW
| De novo designed rhomboid protease-like fold RPF_9 | Descriptor: | De novo designed soluble Rhomboid protease-like protein, SODIUM ION | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Computational design of soluble functional analogues of integral membrane proteins. Biorxiv, 2024
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8OYY
| De novo designed soluble GPCR-like fold GLF_32 | Descriptor: | CHLORIDE ION, De novo designed soluble GPCR-like protein, POTASSIUM ION | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Computational design of soluble functional analogues of integral membrane proteins. Biorxiv, 2024
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8OYS
| De novo designed TIM barrel fold TBF_24 | Descriptor: | CHLORIDE ION, De novo designed TIM-barrel | Authors: | Pacesa, M, Correia, B.E. | Deposit date: | 2023-05-05 | Release date: | 2023-10-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Computational design of soluble functional analogues of integral membrane proteins. Biorxiv, 2024
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4JLR
| Crystal structure of a designed Respiratory Syncytial Virus Immunogen in complex with Motavizumab | Descriptor: | Motavizumab Fab heavy chain, Motavizumab Fab light chain, PENTAETHYLENE GLYCOL, ... | Authors: | Rupert, P.B, Correia, B, Schief, W, Strong, R.K. | Deposit date: | 2013-03-12 | Release date: | 2014-02-05 | Last modified: | 2014-12-17 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Proof of principle for epitope-focused vaccine design. Nature, 507, 2014
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3LEF
| Crystal structure of HIV epitope-scaffold 4E10_S0_1Z6NA_001 | Descriptor: | 1,2-ETHANEDIOL, Uncharacterized protein 4E10_S0_1Z6NA_001 (T18) | Authors: | Holmes, M.A. | Deposit date: | 2010-01-14 | Release date: | 2010-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
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3LF6
| Crystal structure of HIV epitope-scaffold 4E10_1XIZA_S0_001_N | Descriptor: | PHOSPHATE ION, Putative phosphotransferase system | Authors: | Holmes, M.A. | Deposit date: | 2010-01-15 | Release date: | 2010-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
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3T43
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4L8I
| Crystal structure of RSV epitope scaffold FFL_005 | Descriptor: | RSV epitope scaffold FFL_005 | Authors: | Jardine, J, Correnti, C, Holmes, M.A, Strong, R.K, Schief, W.R. | Deposit date: | 2013-06-17 | Release date: | 2014-02-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Proof of principle for epitope-focused vaccine design. Nature, 507, 2014
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4N9G
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3LG7
| Crystal structure of HIV epitope-scaffold 4E10_S0_1EZ3A_002_C | Descriptor: | 4E10_S0_1EZ3A_002_C (T246), SULFATE ION | Authors: | Holmes, M.A. | Deposit date: | 2010-01-19 | Release date: | 2010-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
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3LHP
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3LH2
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3LF9
| Crystal structure of HIV epitope-scaffold 4E10_D0_1IS1A_001_C | Descriptor: | 4E10_D0_1IS1A_001_C (T161) | Authors: | Holmes, M.A. | Deposit date: | 2010-01-16 | Release date: | 2010-09-22 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010
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6VTW
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9BEI
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