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8PRK
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THE R78K AND D117E ACTIVE SITE VARIANTS OF SACCHAROMYCES CEREVISIAE SOLUBLE INORGANIC PYROPHOSPHATASE: STRUCTURAL STUDIES AND MECHANISTIC IMPLICATIONS
Descriptor:PROTEIN (INORGANIC PYROPHOSPHATASE), MANGANESE (II) ION, PHOSPHATE ION
Authors:Tuominen, V., Heikinheimo, P., Kajander, T., Torkkel, T., Hyytia, T., Kapyla, J., Lahti, R., Cooperman, B.S., Goldman, A.
Deposit date:1998-09-16
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.
J.Mol.Biol., 284, 1998
117E
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THE R78K AND D117E ACTIVE SITE VARIANTS OF SACCHAROMYCES CEREVISIAE SOLUBLE INORGANIC PYROPHOSPHATASE: STRUCTURAL STUDIES AND MECHANISTIC IMPLICATIONS
Descriptor:PROTEIN (INORGANIC PYROPHOSPHATASE), MANGANESE (II) ION, PHOSPHATE ION
Authors:Tuominen, V., Heikinheimo, P., Kajander, T., Torkkel, T., Hyytia, T., Kapyla, J., Lahti, R., Cooperman, B.S., Goldman, A.
Deposit date:1998-09-15
Release date:1998-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications.
J.Mol.Biol., 284, 1998
1AFT
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SMALL SUBUNIT C-TERMINAL INHIBITORY PEPTIDE OF MOUSE RIBONUCLEOTIDE REDUCTASE AS BOUND TO THE LARGE SUBUNIT, NMR, 26 STRUCTURES
Descriptor:RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE
Authors:Laub, P.B., Fisher, A.L., Furst, G.T., Barwis, B.A., Hamann, C.S., Cooperman, B.S.
Deposit date:1997-03-13
Release date:1997-05-15
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.
Nat.Struct.Biol., 2, 1995
1E6A
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FLUORIDE-INHIBITED SUBSTRATE COMPLEX OF SACCHAROMYCES CEREVISIAE INORGANIC PYROPHOSPHATASE
Descriptor:INORGANIC PYROPHOSPHATASE, MANGANESE (II) ION, PYROPHOSPHATE 2-, ...
Authors:Heikinheimo, P., Tuominen, V., Ahonen, A.-K., Teplyakov, A., Cooperman, B.S., Baykov, A.A., Lahti, R., Goldman, A.
Deposit date:2000-08-09
Release date:2001-03-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Toward a quantum-mechanical description of metal-assisted phosphoryl transfer in pyrophosphatase.
Proc. Natl. Acad. Sci. U.S.A., 98, 2001
1E9G
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STRUCTURE OF INORGANIC PYROPHOSPHATASE
Descriptor:INORGANIC PYROPHOSPHATASE, MANGANESE (II) ION, PHOSPHATE ION
Authors:Heikinheimo, P., Tuominen, V., Ahonen, A.-K., Teplyakov, A., Cooperman, B.S., Baykov, A.A., Lahti, R., Goldman, A.
Deposit date:2000-10-12
Release date:2001-03-19
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Toward a Quantum-Mechanical Description of Metal-Assisted Phosphoryl Transfer in Pyrophosphatase
Proc.Natl.Acad.Sci.USA, 98, 2001
1FOZ
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STRUCTURE OF CYCLIC PEPTIDE INHIBITORS OF MAMMALIAN RIBONUCLEOTIDE REDUCTASE
Descriptor:SYNTHETIC CYCLIC PEPTIDE
Authors:Pellegrini, M., Liehr, S., Fisher, A.L., Cooperman, B.S., Mierke, D.F.
Deposit date:2000-08-29
Release date:2000-11-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure-based optimization of peptide inhibitors of mammalian ribonucleotide reductase.
Biochemistry, 39, 2000
1HUJ
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REFINED STRUCTURE OF YEAST INORGANIC PYROPHOSPHATASE AND ITS K61R MUTANT
Descriptor:INORGANIC PYROPHOSPHATASE, MAGNESIUM ION
Authors:Swaminathan, K., Cooperman, B.S., Lahti, R., Voet, D.
Deposit date:1997-12-26
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Refined Structure of Yeast Inorganic Pyrophosphatase and its K61R Mutant
To be Published
1HUK
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REFINED STRUCTURE OF YEAST INORGANIC PYROPHOSPHATASE AND ITS K61R MUTANT
Descriptor:INORGANIC PYROPHOSPHATASE, MAGNESIUM ION
Authors:Swaminathan, K., Cooperman, B.S., Lahti, R., Voet, D.
Deposit date:1997-12-26
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined Structure of Yeast Inorganic Pyrophosphatase and its K61R Mutant
To be Published
2ZLF
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THE STRUCTURAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, FTLDADF
Authors:Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
2ZLG
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THE STRUCTUAL BASIS FOR PEPTIDOMIMETIC INHIBITION OF EUKARYOTIC RIBONUCLEOTIDE REDUCTASE
Descriptor:Ribonucleoside-diphosphate reductase large chain 1, (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL
Authors:Xu, H., Fairman, J.W., Wijerathna, S.R., LaMacchia, J., Kreischer, N.R., Helmbrecht, E., Cooperman, B.S., Dealwis, C.
Deposit date:2008-04-09
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore
J.Med.Chem., 51, 2008
1IPW
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INORGANIC PYROPHOSPHATASE FROM ESCHERICHIA COLI WITH THREE MAGNESIUM IONS
Descriptor:SOLUBLE INORGANIC PYROPHOSPHATASE, MAGNESIUM ION
Authors:Kankare, J.A., Goldman, A.
Deposit date:1996-03-04
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic identification of metal-binding sites in Escherichia coli inorganic pyrophosphatase.
Biochemistry, 35, 1996
1FAJ
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INORGANIC PYROPHOSPHATASE
Descriptor:SOLUBLE INORGANIC PYROPHOSPHATASE
Authors:Kankare, J.A., Salminen, T., Goldman, A.
Deposit date:1996-01-10
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Escherichia coli inorganic pyrophosphatase at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 52, 1996
2EIP
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INORGANIC PYROPHOSPHATASE
Descriptor:SOLUBLE INORGANIC PYROPHOSPHATASE
Authors:Kankare, J.A., Salminen, T., Goldman, A.
Deposit date:1996-01-10
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Escherichia coli inorganic pyrophosphatase at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 52, 1996
1WGI
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STRUCTURE OF INORGANIC PYROPHOSPHATASE
Descriptor:INORGANIC PYROPHOSPHATASE, MANGANESE (II) ION
Authors:Heikinheimo, P., Goldman, A.
Deposit date:1996-10-24
Release date:1997-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis for pyrophosphatase catalysis.
Structure, 4, 1996
1WGJ
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STRUCTURE OF INORGANIC PYROPHOSPHATASE
Descriptor:INORGANIC PYROPHOSPHATASE, MANGANESE (II) ION, PHOSPHATE ION
Authors:Heikinheimo, P., Lehtonen, J., Goldman, A.
Deposit date:1996-10-24
Release date:1997-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis for pyrophosphatase catalysis.
Structure, 4, 1996
1YPP
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ACID ANHYDRIDE HYDROLASE
Descriptor:INORGANIC PYROPHOSPHATASE, MANGANESE (II) ION, PHOSPHATE ION
Authors:Harutyunyan, E.H., Kuranova, I.P., Lamzin, V.S., Dauter, Z., Wilson, K.S.
Deposit date:1996-05-29
Release date:1996-12-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structure of yeast inorganic pyrophosphatase complexed with manganese and phosphate.
Eur.J.Biochem., 239, 1996
6EZE
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THE OPEN CONFORMATION OF E.COLI ELONGATION FACTOR TU IN COMPLEX WITH GDPNP.
Descriptor:Elongation factor Tu 2, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ...
Authors:Johansen, J.S., Blaise, M., Thirup, S.S.
Deposit date:2017-11-15
Release date:2018-08-22
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form.
Nucleic Acids Res., 46, 2018
1AS4
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CLEAVED ANTICHYMOTRYPSIN A349R
Descriptor:ANTICHYMOTRYPSIN, ACETATE ION
Authors:Lukacs, C.M., Christianson, D.W.
Deposit date:1997-08-12
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998