Author results

2VKP
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CRYSTAL STRUCTURE OF BTB DOMAIN FROM BTBD6
Descriptor:BTB/POZ DOMAIN-CONTAINING PROTEIN 6, POTASSIUM ION, 1,2-ETHANEDIOL
Authors:Cooper, C.D.O., Pike, A.C.W., Salah, E., Filippakopoulos, P., Bunkoczi, G., Elkins, J.M., von Delft, F., Gileadi, O., Edwards, A., Weigelt, J., Arrowsmith, C.H., Knapp, S.
Deposit date:2007-12-21
Release date:2008-02-12
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Btb Domain from Btbd6
To be Published
2VPK
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF HUMAN MYONEURIN
Descriptor:MYONEURIN
Authors:Cooper, C.D.O., Murray, J.W., Bullock, A., Pike, A.C.W., von Delft, F., Filippakopoulos, P., Salah, E., Edwards, A., Arrowsmith, C.H., Bountra, C., Weigelt, J., Knapp, S.
Deposit date:2008-02-29
Release date:2008-03-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Btb Domain of Human Myoneurin
To be Published
3ZP5
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CRYSTAL STRUCTURE OF THE DNA BINDING ETS DOMAIN OF THE HUMAN PROTEIN FEV IN COMPLEX WITH DNA
Descriptor:PROTEIN FEV, 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3', 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3'
Authors:Newman, J.A., Cooper, C.D.O., Krojer, T., Shrestha, L., Allerston, C.K., Vollmar, M., Arrowsmith, C.H., Burgess-Brown, N., Edwards, A., von Delft, F., Gileadi, O.
Deposit date:2013-02-26
Release date:2013-03-06
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4AVP
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CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN ETV1.
Descriptor:ETS TRANSLOCATION VARIANT 1, 1,2-ETHANEDIOL
Authors:Allerston, C.K., Cooper, C.D.O., Krojer, T., Chaikuad, A., Filippakopoulos, P., Canning, P., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-05-28
Release date:2012-06-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4BNC
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CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN ETV1 COMPLEXED WITH DNA
Descriptor:HUMAN ETV1, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3'
Authors:Allerston, C.K., Cooper, C.D.O., Krojer, T., Chaikuad, A., Vollmar, M., Froese, D.S., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2013-05-14
Release date:2013-07-03
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4CO8
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STRUCTURE OF THE DNA BINDING ETS DOMAIN OF HUMAN ETV4
Descriptor:ETS TRANSLOCATION VARIANT 4, 1,2-ETHANEDIOL
Authors:Newman, J.A., Cooper, C.D.O., Shrestha, L., Burgess-Brown, N., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O.
Deposit date:2014-01-27
Release date:2014-02-05
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4UNO
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CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETV5 IN COMPLEX WITH DNA
Descriptor:ETS TRANSLOCATION VARIANT 5, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3', ...
Authors:Newman, J.A., Aitkenhead, H., Cooper, C.D.O., Pinkas, D.M., Shrestha, L., Burgess-Brown, N., Kopec, J., Fitzpatrick, F., Tallant, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2014-05-29
Release date:2014-06-11
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
4UUV
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STRUCTURE OF THE DNA BINDING ETS DOMAIN OF HUMAN ETV4 IN COMPLEX WITH DNA
Descriptor:ETS TRANSLOCATION VARIANT 4, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3'
Authors:Newman, J.A., Cooper, C.D.O., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O.
Deposit date:2014-07-31
Release date:2014-08-13
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of the Ets Domains of Transcription Factors Etv1, Etv4, Etv5 and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation.
J.Biol.Chem., 290, 2015
2WA0
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CRYSTAL STRUCTURE OF THE HUMAN MAGEA4
Descriptor:MELANOMA-ASSOCIATED ANTIGEN 4
Authors:Roos, A.K., Cooper, C.D.O., Ugochukwu, E., W Yue, W., Berridge, G., Elkins, J.M., Pike, A.C.W., Bray, J., Filippakopoulos, P., Muniz, J., Chaikuad, A., Burgess-Brown, N., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., von Delft, F., Gileadi, O., Oppermann, U.
Deposit date:2009-01-31
Release date:2009-03-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.
Plos One, 11, 2016
2WWY
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STRUCTURE OF HUMAN RECQ-LIKE HELICASE IN COMPLEX WITH A DNA SUBSTRATE
Descriptor:ATP-DEPENDENT DNA HELICASE Q1, DNA OLIGO (27BP), 5'-D(*DA DG DC DG DT DC DG DA DG DA DT DC DCP)-3', ...
Authors:Pike, A.C.W., Zhang, Y., Schnecke, C., Chaikuad, A., Krojer, T., Cooper, C.D.O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Gileadi, O.
Deposit date:2009-10-30
Release date:2009-12-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Recq1 Helicase-Driven DNA Unwinding, Annealing, and Branch Migration: Insights from DNA Complex Structures
Proc.Natl.Acad.Sci.USA, 112, 2015
2XN4
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CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL2 (MAYVEN)
Descriptor:KELCH-LIKE PROTEIN 2, SODIUM ION, SULFATE ION, ...
Authors:Canning, P., Hozjan, V., Cooper, C.D.O., Ayinampudi, V., Vollmar, M., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N.
Deposit date:2010-07-30
Release date:2010-08-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
2XSN
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CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTIC DOMAIN
Descriptor:TYROSINE 3-MONOOXYGENASE, ZINC ION
Authors:Muniz, J.R.C., Cooper, C.D.O., Yue, W.W., Krysztofinska, E., von Delft, F., Knapp, S., Gileadi, O., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Kavanagh, K.L., Oppermann, U.
Deposit date:2010-10-29
Release date:2010-11-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain
To be Published
3I3N
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CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMAN KLHL11
Descriptor:Kelch-like protein 11, THIOCYANATE ION, CHLORIDE ION
Authors:Murray, J.W., Cooper, C.D.O., Krojer, T., Mahajan, P., Salah, E., Keates, T., Savitsky, P., Pike, A.C.W., Roos, A., Muniz, J., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the BTB-BACK domains of human KLHL11
To be Published
3OP0
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CRYSTAL STRUCTURE OF CBL-C (CBL-3) TKB DOMAIN IN COMPLEX WITH EGFR PY1069 PEPTIDE
Descriptor:Signal transduction protein CBL-C, Epidermal growth factor receptor, SODIUM ION, ...
Authors:Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Vollmar, M., Canning, P., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published
3P1A
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STRUCTURE OF HUMAN MEMBRANE-ASSOCIATED TYROSINE- AND THREONINE-SPECIFIC CDC2-INHIBITORY KINASE MYT1 (PKMYT1)
Descriptor:Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE
Authors:Chaikuad, A., Eswaran, J., Fedorov, O., Cooper, C.D.O., Kroeler, T., Vollmar, M., Krojer, T., Berridge, G., Muniz, J.R.C., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of human Membrane-associated Tyrosine- and Threonine-specific cdc2-inhibitory kinase MYT1 (PKMYT1)
To be Published
3PFV
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CRYSTAL STRUCTURE OF CBL-B TKB DOMAIN IN COMPLEX WITH EGFR PY1069 PEPTIDE
Descriptor:E3 ubiquitin-protein ligase CBL-B, 11-meric peptide from Epidermal growth factor receptor, SODIUM ION, ...
Authors:Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Muniz, J.R.C., Vollmar, M., Canning, P., Gileadi, O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-10-29
Release date:2010-12-08
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
To be Published
3PRY
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CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HUMAN HSP90-BETA REFINED AT 2.3 A RESOLUTION
Descriptor:Heat shock protein HSP 90-beta, SULFATE ION, GLYCEROL, ...
Authors:Chaikuad, A., Pilka, E., Sharpe, T.D., Cooper, C.D.O., Phillips, C., Berridge, G., Ayinampudi, V., Fedorov, O., Keates, T., Thangaratnarajah, C., Zimmermann, T., Vollmar, M., Yue, W.W., Che, K.H., Krojer, T., Muniz, J.R.C., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-11-30
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution
To be Published
3SOC
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CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA (ACVR2A) KINASE DOMAIN IN COMPLEX WITH A QUINAZOLIN
Descriptor:Activin receptor type-2A, [4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]QUINAZOLIN-2-YL}IMINO)CYCLOHEXA-2,5-DIEN-1-YL]ACETONITRILE, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Williams, E., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Muniz, J.R.C., Yue, W.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2011-06-30
Release date:2011-07-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
To be Published
4AP2
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CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 2.8A RESOLUTION
Descriptor:KELCH-LIKE PROTEIN 11, CULLIN-3, 1,2-ETHANEDIOL, ...
Authors:Canning, P., Cooper, C.D.O., Krojer, T., Filippakopoulos, P., Ayinampudi, V., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-03-30
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4APF
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CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 3.1A RESOLUTION
Descriptor:KELCH-LIKE PROTEIN 11, CULLIN 3
Authors:Canning, P., Cooper, C.D.O., Krojer, T., Vollmar, M., Ugochukwu, E., Muniz, J.R.C., Ayinampudi, V., Savitsky, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC)
Deposit date:2012-04-02
Release date:2012-05-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
4ASX
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CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA (ACVR2A) KINASE DOMAIN IN COMPLEX WITH DIHYDRO-BAUERINE C
Descriptor:ACTIVIN RECEPTOR TYPE-2A, 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2H-pyrido[3,4-b]indol-1-one, 1,2-ETHANEDIOL
Authors:Williams, E., Chaikuad, A., Canning, P., Kochan, G., Mahajan, P., Cooper, C.D.O., Beltrami, A., Krojer, T., Pohl, B., Bracher, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.
Deposit date:2012-05-03
Release date:2012-05-23
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Activin Receptor Type-Iia (Acvr2A) Kinase Domain in Complex with a Beta- Carboline Inhibitor
To be Published
4AVM
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CRYSTAL STRUCTURE OF THE N-BAR DOMAIN OF HUMAN BRIDGING INTEGRATOR 2.
Descriptor:BRIDGING INTEGRATOR 2, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Allerston, C.K., Krojer, T., Cooper, C.D.O., Vollmar, M., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-05-28
Release date:2012-06-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal Structure of the N-Bar Domain of Human Bridging Integrator 2.
To be Published
4B4C
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CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN CHD1.
Descriptor:CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Allerston, C.K., Cooper, C.D.O., Shrestha, L., Vollmar, M., Burgess-Brown, N., Yue, W.W., Carpenter, E.P., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-07-30
Release date:2012-08-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal Structure of the DNA-Binding Domain of Human Chd1.
To be Published
4BBM
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CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312
Descriptor:CYCLIN-DEPENDENT KINASE-LIKE 2, 4'-[5-[[3-[(CYCLOPROPYLAMINO)METHYL]PHENYL]AMINO]-1H-PYRAZOL-3-YL]-[1,1'-BIPHENYL]-2,4-DIOL, CHLORIDE ION, ...
Authors:Canning, P., Elkins, J.M., Cooper, C.D.O., Mahajan, P., Daga, N., Berridge, G., Burgess-Brown, N., Muniz, J.R.C., Krojer, T., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.
Deposit date:2012-09-26
Release date:2012-10-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Human Cdkl2 Kinase Domain with Bound Tcs 2312
To be Published
4BQA
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CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETS2 IN COMPLEX WITH DNA
Descriptor:PROTEIN C-ETS-2, 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3', 5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP)-3'
Authors:Newman, J.A., Cooper, C.D.O., Krojer, T., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2013-05-30
Release date:2013-06-12
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights Into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2.
J.Biol.Chem., 290, 2015
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