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3IPQ
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X-RAY STRUCTURE OF GW3965 SYNTHETIC AGONIST BOUND TO THE LXR-ALPHA
Descriptor:Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, [3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid, ...
Authors:Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGuire, R., Uitdehaag, J.C.M.
Deposit date:2009-08-18
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
J.Mol.Biol., 399, 2010
3IPS
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X-RAY STRUCTURE OF BENZISOXAZOLE SYNTHETIC AGONIST BOUND TO THE LXR-ALPHA
Descriptor:Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, SULFATE ION, ...
Authors:Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGuire, R., Uitdehaag, J.C.M.
Deposit date:2009-08-18
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
J.Mol.Biol., 399, 2010
3IPU
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X-RAY STRUCTURE OF BENZISOXAZOLE UREA SYNTHETIC AGONIST BOUND TO THE LXR-ALPHA
Descriptor:Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, 4-{[methyl(3-{[7-propyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy}propyl)carbamoyl]amino}benzoic acid, ...
Authors:Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGuire, R., Uitdehaag, J.C.M.
Deposit date:2009-08-18
Release date:2010-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.
J.Mol.Biol., 399, 2010
5HJP
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IDENTIFICATION OF LXRBETA SELECTIVE AGONISTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Descriptor:Retinoic acid receptor RXR-beta, Oxysterols receptor LXR-beta, 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, ...
Authors:Parthasarathy, G., Klein, D.
Deposit date:2016-01-13
Release date:2016-04-06
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
J.Med.Chem., 59, 2016
5HJS
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IDENTIFICATION OF LXRBETA SELECTIVE AGONISTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Descriptor:Oxysterols receptor LXR-alpha, Nuclear receptor coactivator 1, 2-chloro-4-{1'-[(2R)-2-hydroxy-3-methyl-2-(trifluoromethyl)butanoyl]-4,4'-bipiperidin-1-yl}-N,N-dimethylbenzamide, ...
Authors:Parthasarathy, G., Klein, D.
Deposit date:2016-01-13
Release date:2016-04-06
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Identification and in Vivo Evaluation of Liver X Receptor beta-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
J.Med.Chem., 59, 2016
5KMI
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TRKA JM-KINASE WITH 1-(9{H}-FLUOREN-9-YL)-3-(2-METHYL-4-PHENYL-PYRIMIDIN-5-YL)UREA
Descriptor:High affinity nerve growth factor receptor, 1-(9~{H}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea
Authors:Su, H.P.
Deposit date:2016-06-27
Release date:2016-12-28
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KMJ
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TRKA JM-KINASE WITH {N}-(2-PYRIDYLMETHYL)-2-[2-(2-THIENYL)INDOL-1-YL]ACETAMIDE
Descriptor:High affinity nerve growth factor receptor, ~{N}-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamide
Authors:Su, H.P.
Deposit date:2016-06-27
Release date:2016-12-28
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KMK
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TRKA JM-KINASE WITH 2-FLUORO-{N}-[2-(4-FLUOROPHENYL)-6-METHYL-3-PYRIDYL]-4-(TRIFLUOROMETHYL)BENZAMIDE
Descriptor:High affinity nerve growth factor receptor, 2-fluoranyl-~{N}-[2-(4-fluorophenyl)-6-methyl-pyridin-3-yl]-4-(trifluoromethyl)benzamide
Authors:Su, H.P.
Deposit date:2016-06-27
Release date:2016-12-28
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KML
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TRKA JM-KINASE WITH 1-(5-METHYL-3-PHENYL-1,2-OXAZOL-4-YL)-3-[[2-(TRIFLUOROMETHYL)PHENYL]METHYL]UREA
Descriptor:High affinity nerve growth factor receptor, 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea
Authors:Su, H.P.
Deposit date:2016-06-27
Release date:2016-12-28
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KMM
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TRKA JM-KINASE WITH 1-(2-METHYL-4-PHENYL-PYRIMIDIN-5-YL)-3-(1-NAPHTHYL)UREA
Descriptor:High affinity nerve growth factor receptor, 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-naphthalen-1-yl-urea
Authors:Su, H.P.
Deposit date:2016-06-27
Release date:2016-12-28
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KMN
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TRKA JM-KINASE WITH 1-(2-METHYL-4-PHENYL-PYRIMIDIN-5-YL)-3-[[2-(TRIFLUOROMETHYL)PHENYL]METHYL]UREA
Descriptor:High affinity nerve growth factor receptor, 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea
Authors:Su, H.P.
Deposit date:2016-06-27
Release date:2016-12-28
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KMO
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TRKA JM-KINASE WITH 1-(2-METHYL-4-PHENYL-PYRIMIDIN-5-YL)-3-(2-PYRIDYL)UREA
Descriptor:High affinity nerve growth factor receptor, 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-pyridin-2-yl-urea
Authors:Su, H.P.
Deposit date:2016-06-27
Release date:2016-12-28
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural characterization of nonactive site, TrkA-selective kinase inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017