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2UV1
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BU of 2uv1 by Molmil
Hexagonal crystal form of GamS from bacteriophage lambda.
Descriptor: HOST-NUCLEASE INHIBITOR PROTEIN GAM
Authors:Court, R.I, Cook, N, Saikrishnan, K, Wigley, D.B.
Deposit date:2007-03-08
Release date:2007-06-12
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Crystal Structure of Lambda-Gam Protein Suggests a Model for Recbcd Inhibition.
J.Mol.Biol., 371, 2007
3E1S
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BU of 3e1s by Molmil
Structure of an N-terminal truncation of Deinococcus radiodurans RecD2
Descriptor: Exodeoxyribonuclease V, subunit RecD
Authors:Saikrishnan, K, Griffiths, S.P, Cook, N, Court, R, Wigley, D.B.
Deposit date:2008-08-04
Release date:2008-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:DNA binding to RecD: role of the 1B domain in SF1B helicase activity.
Embo J., 27, 2008
2UUZ
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BU of 2uuz by Molmil
Orthorhombic crystal form of GamS from bacteriophage lambda.
Descriptor: HOST-NUCLEASE INHIBITOR PROTEIN GAM
Authors:Court, R.I, Cook, N, Saikrishnan, K, Wigley, D.B.
Deposit date:2007-03-08
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Crystal Structure of Lambda-Gam Protein Suggests a Model for Recbcd Inhibition.
J.Mol.Biol., 371, 2007
1W5T
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BU of 1w5t by Molmil
Structure of the Aeropyrum Pernix ORC2 protein (ADPNP-ADP complexes)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ORC2, ...
Authors:Singleton, M.R, Morales, R, Grainge, I, Cook, N, Isupov, M.N, Wigley, D.B.
Deposit date:2004-08-09
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational Changes Induced by Nucleotide Binding in Cdc6/Orc from Aeropyrum Pernix
J.Mol.Biol., 343, 2004
1W5S
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BU of 1w5s by Molmil
Structure of the Aeropyrum Pernix ORC2 protein (ADP form)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ORIGIN RECOGNITION COMPLEX SUBUNIT 2 ORC2, SULFATE ION
Authors:Singleton, M.R, Morales, R, Grainge, I, Cook, N, Isupov, M.N, Wigley, D.B.
Deposit date:2004-08-09
Release date:2004-10-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational Changes Induced by Nucleotide Binding in Cdc6/Orc from Aeropyrum Pernix
J.Mol.Biol., 343, 2004
2CHV
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BU of 2chv by Molmil
Replication Factor C ADPNP complex
Descriptor: REPLICATION FACTOR C SMALL SUBUNIT
Authors:Seybert, A, Singleton, M.R, Cook, N, Hall, D.R, Wigley, D.B.
Deposit date:2006-03-16
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Communication between Subunits within an Archaeal Clamp-Loader Complex.
Embo J., 25, 2006
2CHG
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BU of 2chg by Molmil
Replication Factor C domains 1 and 2
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, REPLICATION FACTOR C SMALL SUBUNIT
Authors:Seybert, A, Singleton, M.R, Cook, N, Hall, D.R, Wigley, D.B.
Deposit date:2006-03-14
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Communication between Subunits within an Archaeal Clamp-Loader Complex.
Embo J., 25, 2006
2CHQ
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BU of 2chq by Molmil
Replication Factor C ADPNP complex
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, REPLICATION FACTOR C SMALL SUBUNIT
Authors:Seybert, A, Singleton, M.R, Cook, N, Hall, D.R, Wigley, D.B.
Deposit date:2006-03-16
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Communication between Subunits within an Archaeal Clamp-Loader Complex.
Embo J., 25, 2006
3GPL
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BU of 3gpl by Molmil
Crystal structure of the ternary complex of RecD2 with DNA and ADPNP
Descriptor: 5'-D(*T*TP*TP*TP*TP*TP*TP*T)-3', Exodeoxyribonuclease V, subunit RecD, ...
Authors:Saikrishnan, K, Cook, N, Wigley, D.B.
Deposit date:2009-03-23
Release date:2009-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic basis of 5'-3' translocation in SF1B helicases.
Cell(Cambridge,Mass.), 137, 2009
3GP8
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BU of 3gp8 by Molmil
Crystal structure of the binary complex of RecD2 with DNA
Descriptor: 5'-D(*TP*TP*TP*TP*TP*T*TP*TP*TP*TP*TP*TP*TP*T)-3', Exodeoxyribonuclease V, subunit RecD, ...
Authors:Saikrishnan, K, Cook, N, Wigley, D.B.
Deposit date:2009-03-23
Release date:2009-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanistic basis of 5'-3' translocation in SF1B helicases.
Cell(Cambridge,Mass.), 137, 2009
5CZ1
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BU of 5cz1 by Molmil
Crystal structure of the catalytic core domain of MMTV integrase
Descriptor: integrase
Authors:Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-07-31
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
5CZ2
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BU of 5cz2 by Molmil
Crystal structure of a two-domain fragment of MMTV integrase
Descriptor: MAGNESIUM ION, Pol polyprotein, ZINC ION
Authors:Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P.
Deposit date:2015-07-31
Release date:2016-02-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature, 530, 2016
6GX9
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BU of 6gx9 by Molmil
Crystal structure of the TNPO3 - CPSF6 RSLD complex
Descriptor: BENZAMIDINE, BICINE, Cleavage and polyadenylation specificity factor subunit 6, ...
Authors:Cherepanov, P, Cook, N.
Deposit date:2018-06-26
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Nucleic Acids Res., 47, 2019
6RWO
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BU of 6rwo by Molmil
SIVrcm intasome (Q148H/G140S) in complex with bictegravir
Descriptor: Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWL
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BU of 6rwl by Molmil
SIVrcm intasome
Descriptor: DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3'), Pol protein, ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWN
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BU of 6rwn by Molmil
SIVrcm intasome in complex with dolutegravir
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWM
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BU of 6rwm by Molmil
SIVrcm intasome in complex with bictegravir
Descriptor: Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
3IW4
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BU of 3iw4 by Molmil
Crystal structure of PKC alpha in complex with NVP-AEB071
Descriptor: 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione, Protein kinase C alpha type
Authors:Stark, W, Rummel, G, Strauss, A, Cowan-Jacob, S.W.
Deposit date:2009-09-02
Release date:2009-11-03
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes
J.Med.Chem., 52, 2009
3K70
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BU of 3k70 by Molmil
Crystal structure of the complete initiation complex of RecBCD
Descriptor: CALCIUM ION, DNA (46-MER), Exodeoxyribonuclease V alpha chain, ...
Authors:Saikrishnan, K, Wigley, D.B.
Deposit date:2009-10-11
Release date:2009-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:DNA binding to RecD: role of the 1B domain in SF1B helicase activity.
Embo J., 27, 2008

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