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5KMP
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THE STRUCTURE OF G164E VARIANT OF TYPE II NADH DEHYDROGENASE FROM CALDALKALIBACILLUS THERMARUM
分子名称:FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
著者Cook, G.M., Aragao, D., Nakatani, Y.
登録日2016-06-27
公開日2017-01-25
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The mechanism of catalysis by type-II NADH:quinone oxidoreductases.
Sci Rep, 7, 2017
5KMQ
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THE STRUCTURE OF I379E VARIANT OF TYPE II NADH DEHYDROGENASE FROM CALDALKALIBACILLUS THERMARUM
分子名称:FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
著者Cook, G.M., Aragao, D., Nakatani, Y.
登録日2016-06-27
公開日2017-01-25
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The mechanism of catalysis by type-II NADH:quinone oxidoreductases.
Sci Rep, 7, 2017
5KMR
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THE STRUCTURE OF TYPE II NADH DEHYDROGENASE FROM CALDALKALIBACILLUS THERMARUM COMPLEXED WITH NAD+ AT 3.0 ANGSTROM RESOLUTION.
分子名称:FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Cook, G.M., Aragao, D., Nakatani, Y.
登録日2016-06-27
公開日2017-01-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The mechanism of catalysis by type-II NADH:quinone oxidoreductases.
Sci Rep, 7, 2017
5KMS
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THE STRUCTURE OF TYPE II NADH DEHYDROGENASE FROM CALDALKALIBACILLUS THERMARUM COMPLEXED WITH NAD+ AT 2.5 ANGSTROM RESOLUTION.
分子名称:FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Cook, G.M., Aragao, D., Nakatani, Y.
登録日2016-06-27
公開日2017-02-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The mechanism of catalysis by type-II NADH:quinone oxidoreductases.
Sci Rep, 7, 2017
6BDO
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STRUCTURE OF BACTERIAL TYPE II NADH DEHYDROGENASE FROM CALDALKALIBACILLUS THERMARUM COMPLEXED WITH A QUINONE INHIBITOR HQNO AT 2.8A RESOLUTION
分子名称:FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, 2-HEPTYL-4-HYDROXY QUINOLINE N-OXIDE
著者Cook, G.M., Aragao, D., Nakatani, Y.
登録日2017-10-23
公開日2018-05-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of the NDH-2 - HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors.
Biochim. Biophys. Acta, 1859, 2018
2QE7
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CRYSTAL STRUCTURE OF THE F1-ATPASE FROM THE THERMOALKALIPHILIC BACTERIUM BACILLUS SP. TA2.A1
分子名称:ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase subunit gamma, ...
著者Stocker, A., Keis, S., Vonck, J., Cook, G.M., Dimroth, P.
登録日2007-06-25
公開日2007-08-21
最終更新日2013-05-08
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献The Structural Basis for Unidirectional Rotation of Thermoalkaliphilic F(1)-ATPase.
Structure, 15, 2007
3F8L
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CRYSTAL STRUCTURE OF THE EFFECTOR DOMAIN OF PHNF FROM MYCOBACTERIUM SMEGMATIS
分子名称:HTH-type transcriptional repressor phnF, SULFATE ION, GLYCEROL
著者Busby, J.N., Gebhard, S., Cook, G.M., Baker, E.N., Lott, S.J., Money, V.A.
登録日2008-11-12
公開日2009-11-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of PhnF, a GntR-family transcription regulator in Mycobacterium smegmatis
To be Published
3F8M
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CRYSTAL STRUCTURE OF PHNF FROM MYCOBACTERIUM SMEGMATIS
分子名称:GntR-family protein transcriptional regulator, GLYCEROL
著者Busby, J.N., Gebhard, S., Cook, G.M., Lott, S.J., Baker, E.N., Money, V.A.
登録日2008-11-12
公開日2009-11-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of PhnF, a GntR-family transcription regulator in Mycobacterium smegmatis
To be Published
4BGN
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CRYO-EM STRUCTURE OF THE NAVCT VOLTAGE-GATED SODIUM CHANNEL
分子名称:VOLTAGE-GATED SODIUM CHANNEL
著者Tsai, C.J., Tani, K., Irie, K., Hiroaki, Y., Shimomura, T., Mcmillan, D.G., Cook, G.M., Schertler, G., Fujiyoshi, Y., Li, X.D.
登録日2013-03-28
公開日2013-07-10
最終更新日2013-11-13
実験手法ELECTRON CRYSTALLOGRAPHY (9 Å)
主引用文献Two Alternative Conformations of a Voltage-Gated Sodium Channel.
J.Mol.Biol., 425, 2013
4NWZ
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STRUCTURE OF BACTERIAL TYPE II NADH DEHYDROGENASE FROM CALDALKALIBACILLUS THERMARUM AT 2.5A RESOLUTION
分子名称:FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
著者Nakatani, Y., Heikal, A., Lott, J.S., Sazanov, L.A., Baker, E.N., Cook, G.M.
登録日2013-12-07
公開日2014-02-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation.
Mol.Microbiol., 2014
5HKK
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CALDALAKLIBACILLUS THERMARUM F1-ATPASE (WILD TYPE)
分子名称:ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase gamma chain, ...
著者Ferguson, S.A., Cook, G.M., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
登録日2016-01-14
公開日2016-09-21
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Regulation of the thermoalkaliphilic F1-ATPase from Caldalkalibacillus thermarum.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IK2
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CALDALAKLIBACILLUS THERMARUM F1-ATPASE (EPSILON MUTANT)
分子名称:ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase gamma chain, ...
著者Ferguson, S.A., Cook, G.M., Montgomery, M.G., Leslie, A.G.W., Walker, J.E.
登録日2016-03-03
公開日2016-09-21
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Regulation of the thermoalkaliphilic F1-ATPase from Caldalkalibacillus thermarum.
Proc.Natl.Acad.Sci.USA, 113, 2016
5WED
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STRUCTURE OF BACTERIAL TYPE II NADH DEHYDROGENASE FROM CALDALKALIBACILLUS THERMARUM AT 2.15A RESOLUTION
分子名称:FAD-dependent pyridine nucleotide-disulfide oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
著者Nakatani, Y., Aragao, D., Cook, G.M.
登録日2017-07-09
公開日2017-10-18
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of type II NADH:quinone oxidoreductase from Caldalkalibacillus thermarum with an improved resolution of 2.15 angstrom.
Acta Crystallogr F Struct Biol Commun, 73, 2017
6FOC
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F1-ATPASE FROM MYCOBACTERIUM SMEGMATIS
分子名称:ATP synthase subunit alpha,ATP synthase subunit alpha,ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase gamma chain, ...
著者Zhang, T., Montgomery, M.G., Leslie, A.G.W., Cook, G.M., Walker, J.E.
登録日2018-02-06
公開日2019-01-23
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献The structure of the catalytic domain of the ATP synthase fromMycobacterium smegmatisis a target for developing antitubercular drugs.
Proc. Natl. Acad. Sci. U.S.A., 2019
6Q45
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F1-ATPASE FROM FUSOBACTERIUM NUCLEATUM
分子名称:ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase gamma chain, ...
著者Petri, J., Nakatani, Y., Montgomery, M.G., Ferguson, S.A., Aragao, D., Leslie, A.G.W., Heikal, A., Walker, J.E., Cook, G.M.
登録日2018-12-05
公開日2019-07-10
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structure of F1-ATPase from the obligate anaerobe Fusobacterium nucleatum.
Open Biology, 9, 2019
5ZA7
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UPA-HMA
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide, SULFATE ION
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-06
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZA8
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UPA-BB2-27F
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(1-methylpyrazol-4-yl)pyrazine-2-carboxamide
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-06
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZA9
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UPA-BB2-50F
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-07
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAE
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UPA-6F-HMA
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide, SULFATE ION
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-07
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAF
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UPA-BB2-28F
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-3-yl)pyrazine-2-carboxamide
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-07
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAG
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UPA-BB2-94F
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-pyrimidin-5-yl-pyrazine-2-carboxamide
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-07
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAH
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UPA-BB2-30F
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-07
公開日2018-12-19
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAJ
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UPA-31F
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
著者Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-07
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZC5
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UPA-NU-09F
分子名称:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(4-fluoranyl-1-benzofuran-2-yl)pyrazine-2-carboxamide
著者Jiang, L.G., Buckley, B.J., Huang, M.D., Kelso, M.J., Ranson, M.
登録日2018-02-15
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
3ZK1
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CRYSTAL STRUCTURE OF THE SODIUM BINDING ROTOR RING AT PH 5.3
分子名称:ATP SYNTHASE SUBUNIT C, SODIUM ION, DECYL-BETA-D-MALTOPYRANOSIDE, ...
著者Schulz, S., Meier, T., Yildiz, O.
登録日2013-01-21
公開日2013-05-29
最終更新日2013-09-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A New Type of Na(+)-Driven ATP Synthase Membrane Rotor with a Two-Carboxylate Ion-Coupling Motif.
Plos Biol., 11, 2013
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