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1Z3H
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BU of 1z3h by Molmil
The exportin Cse1 in its cargo-free, cytoplasmic state
Descriptor: Importin alpha re-exporter, MAGNESIUM ION
Authors:Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E.
Deposit date:2005-03-12
Release date:2005-05-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding
Mol.Cell, 18, 2005
1GY3
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BU of 1gy3 by Molmil
pCDK2/cyclin A in complex with MgADP, nitrate and peptide substrate
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ...
Authors:Cook, A, Lowe, E.D, Chrysina, E.D, Skamnaki, V.T, Oikonomakos, N.G, Johnson, L.N.
Deposit date:2002-04-19
Release date:2002-04-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Studies on Phospho-Cdk2/Cyclin a Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism
Biochemistry, 41, 2002
1E3F
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BU of 1e3f by Molmil
Structure of human transthyretin complexed with bromophenols: a new mode of binding
Descriptor: TRANSTHYRETIN
Authors:Ghosh, M, Meerts, I.A.T.M, Cook, A, Bergman, A, Brouwer, A, Johnson, L.N.
Deposit date:2000-06-14
Release date:2000-08-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Human Transthyretin Complexed with Bromophenols : A New Mode of Binding
Acta Crystallogr.,Sect.D, 56, 2000
1E4H
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BU of 1e4h by Molmil
Structure of human transthyretin complexed with bromophenols: a new mode of binding
Descriptor: GLYCEROL, PENTABROMOPHENOL, TRANSTHYRETIN
Authors:Ghosh, M, Meerts, I.A.T.M, Cook, A, Bergman, A, Brouwer, A, Johnson, L.N.
Deposit date:2000-07-04
Release date:2000-08-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Human Transthyretin Complexed with Bromophenols : A New Mode of Binding
Acta Crystallogr.,Sect.D, 56, 2000
1E5A
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BU of 1e5a by Molmil
Structure of human transthyretin complexed with bromophenols: a new mode of binding
Descriptor: 2,4,6-TRIBROMOPHENOL, TRANSTHYRETIN
Authors:Ghosh, M, Meerts, I.A.T.M, Cook, A, Bergman, A, Brouwer, A, Johnson, L.N.
Deposit date:2000-07-20
Release date:2000-08-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Human Transthyretin Complexed with Bromophenols : A New Mode of Binding
Acta Crystallogr.,Sect.D, 56, 2000
1W98
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BU of 1w98 by Molmil
The structural basis of CDK2 activation by cyclin E
Descriptor: CELL DIVISION PROTEIN KINASE 2, G1/S-SPECIFIC CYCLIN E1
Authors:Lowe, E.D, Honda, R, Dubinina, E, Skamnaki, V, Cook, A, Johnson, L.N.
Deposit date:2004-10-07
Release date:2005-02-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The Structure of Cyclin E1/Cdk2: Implications for Cdk2 Activation and Cdk2-Independent Roles
Embo J., 24, 2005
5ND7
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BU of 5nd7 by Molmil
Microtubule-bound MKLP2 motor domain in the presence of AMPPNP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ...
Authors:Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A.
Deposit date:2017-03-07
Release date:2017-10-04
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
5ND4
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BU of 5nd4 by Molmil
Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A.
Deposit date:2017-03-07
Release date:2017-10-04
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
5ND2
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BU of 5nd2 by Molmil
Microtubule-bound MKLP2 motor domain in the presence of ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A.
Deposit date:2017-03-07
Release date:2017-10-04
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
5ND3
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BU of 5nd3 by Molmil
Microtubule-bound MKLP2 motor domain in the with no nucleotide
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ...
Authors:Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A.
Deposit date:2017-03-07
Release date:2017-10-04
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
4ID7
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BU of 4id7 by Molmil
ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol
Descriptor: Activated CDC42 kinase 1, SULFATE ION, cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol
Authors:Jin, M, Wang, J, Kleinberg, A, Kadalbajoo, M, Siu, K, Cooke, A, Bittner, M, Yao, Y, Thelemann, A, Ji, Q, Bhagwat, S, Crew, A.P, Pachter, J, Epstein, D, Mulvihill, M.J.
Deposit date:2012-12-11
Release date:2013-01-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4E47
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BU of 4e47 by Molmil
SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine
Descriptor: (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETD7, ...
Authors:Walker, J.R, Ouyang, H, Dong, A, Fish, P, Cook, A, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2012-03-12
Release date:2012-03-28
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Setd7 in Complex with Inhibitor and SAM
To be Published
6QVJ
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BU of 6qvj by Molmil
HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule
Descriptor: Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-03-02
Release date:2019-11-27
Last modified:2020-09-09
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
6QUY
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BU of 6quy by Molmil
NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule
Descriptor: CKK domain protein, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-02-28
Release date:2019-11-27
Last modified:2021-02-10
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
6QVE
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BU of 6qve by Molmil
NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule
Descriptor: Beta1-tubulin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-03-01
Release date:2019-11-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
6QUS
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BU of 6qus by Molmil
HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule
Descriptor: Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-02-28
Release date:2019-11-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
6W2J
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BU of 6w2j by Molmil
CPS1 bound to allosteric inhibitor H3B-374
Descriptor: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ...
Authors:Larsen, N.A, Nguyen, T.V.
Deposit date:2020-03-05
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Acs Med.Chem.Lett., 11, 2020
7B0I
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BU of 7b0i by Molmil
Structure of a minimal SF3B core in complex with spliceostatin A (form II)
Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3,Splicing factor 3B subunit 3,Splicing factor 3B subunit 3, ...
Authors:Cretu, C, Pena, V.
Deposit date:2020-11-19
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.
Nat Commun, 12, 2021
7B92
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BU of 7b92 by Molmil
Structure of a minimal SF3B core in complex with sudemycin D6 (form II)
Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ...
Authors:Cretu, C, Pena, V.
Deposit date:2020-12-14
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.
Nat Commun, 12, 2021
7B9C
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BU of 7b9c by Molmil
Structure of a minimal SF3B core in complex with spliceostatin A (form I)
Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ...
Authors:Cretu, C, Pena, V.
Deposit date:2020-12-14
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.
Nat Commun, 12, 2021
7B91
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BU of 7b91 by Molmil
Structure of a minimal SF3B core in complex with pladienolide D (form I)
Descriptor: PHD finger-like domain-containing protein 5A, Splicing factor 3B subunit 1, Splicing factor 3B subunit 3, ...
Authors:Cretu, C, Pena, V.
Deposit date:2020-12-13
Release date:2021-08-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.
Nat Commun, 12, 2021
3SOS
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BU of 3sos by Molmil
Benzothiazinone inhibitor in complex with FXIa
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CITRIC ACID, Coagulation factor XI, ...
Authors:Fradera, X, Kazemier, B, Oubrie, A.
Deposit date:2011-06-30
Release date:2012-04-11
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Acta Crystallogr.,Sect.F, 68, 2012
3SOR
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BU of 3sor by Molmil
Factor XIa in complex with a clorophenyl-tetrazole inhibitor
Descriptor: CITRIC ACID, Coagulation factor XI, {4-[(N-{3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}-L-phenylalanyl)amino]phenyl}acetic acid
Authors:Kazemier, B, Oubrie, A.
Deposit date:2011-06-30
Release date:2012-04-11
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Acta Crystallogr.,Sect.F, 68, 2012
5ZYA
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BU of 5zya by Molmil
SF3b spliceosomal complex bound to E7107
Descriptor: PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ...
Authors:Finci, L.I, Larsen, N.A.
Deposit date:2018-05-23
Release date:2018-06-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
Genes Dev., 32, 2018
8SOR
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BU of 8sor by Molmil
Structure of human PI3KC3-C1 complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Beclin 1-associated autophagy-related key regulator, Beclin-1, ...
Authors:Chen, M, Hurley, J.H.
Deposit date:2023-04-29
Release date:2023-06-21
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
bioRxiv, 2023

 

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