1AL5
 
 | | A-TRACT RNA DODECAMER, NMR, 12 STRUCTURES | | Descriptor: | RNA (5'-R(*CP*GP*CP*AP*AP*AP*UP*UP*UP*GP*CP*G)-3') | | Authors: | Conte, M.R, Conn, G.L, Brown, T, Lane, A.N. | | Deposit date: | 1997-06-11 | | Release date: | 1997-12-17 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2.
Nucleic Acids Res., 25, 1997
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2G2K
 | | NMR structure of an N-terminal fragment of the eukaryotic initiation factor 5 (eIF5) | | Descriptor: | Eukaryotic translation initiation factor 5 | | Authors: | Conte, M.R, Kelly, G, Babon, J, Sanfelice, D, Smerdon, S.J, Proud, C.G. | | Deposit date: | 2006-02-16 | | Release date: | 2006-06-13 | | Last modified: | 2021-11-10 | | Method: | SOLUTION NMR | | Cite: | Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors
Biochemistry, 45, 2006
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1QM9
 | | NMR, REPRESENTATIVE STRUCTURE | | Descriptor: | POLYPYRIMIDINE TRACT-BINDING PROTEIN | | Authors: | Conte, M.R, Grune, T, Curry, S, Matthews, S. | | Deposit date: | 1999-09-22 | | Release date: | 2000-07-03 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Structure of Tandem RNA Recognition Motifs from Polypyrimidine Tract Binding Protein Reveals Novel Features of the Rrm Fold
Embo J., 19, 2000
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1BAX
 | | MASON-PFIZER MONKEY VIRUS MATRIX PROTEIN, NMR, AVERAGE STRUCTURE | | Descriptor: | M-PMV MATRIX PROTEIN | | Authors: | Conte, M.R, Klikova, M, Hunter, E, Ruml, T, Matthews, S. | | Deposit date: | 1998-04-20 | | Release date: | 1998-06-17 | | Last modified: | 2024-04-10 | | Method: | SOLUTION NMR | | Cite: | The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly.
EMBO J., 16, 1997
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1SAA
 | | ATF-2 RECOGNITION SITE, NMR, 10 STRUCTURES | | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*TP*GP*AP*CP*GP*TP*CP*AP*CP*AP*TP*G)-3') | | Authors: | Conte, M.R, Lane, A.N, Bloomberg, G. | | Deposit date: | 1997-08-19 | | Release date: | 1997-11-12 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the ATF-2 recognition site and its interaction with the ATF-2 peptide.
Nucleic Acids Res., 25, 1997
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6I9B
 | | NMR structure of the La module from human LARP4A | | Descriptor: | La-related protein 4 | | Authors: | Conte, M.R, Martino, L, Atkinson, R.A, Kelly, G, Cruz-Gallardo, I, De Tito, S, Trotta, R. | | Deposit date: | 2018-11-22 | | Release date: | 2019-03-13 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
Nucleic Acids Res., 47, 2019
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2L8K
 | | NMR Structure of the Arterivirus nonstructural protein 7 alpha (nsp7 alpha) | | Descriptor: | Non-structural protein 7 | | Authors: | Conte, M.R, Gaudin, C, Manolaridis, I, Tucker, P.W, Kelly, G. | | Deposit date: | 2011-01-19 | | Release date: | 2011-07-06 | | Last modified: | 2023-02-08 | | Method: | SOLUTION NMR | | Cite: | Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}.
J.Virol., 85, 2011
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6I5G
 | | X-ray structure of human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD)in complex with 15d-PGJ2 | | Descriptor: | (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid, 1,2-ETHANEDIOL, Bifunctional epoxide hydrolase 2 | | Authors: | Abis, G, Kopec, J, Yue, W.W, Conte, M.R. | | Deposit date: | 2018-11-13 | | Release date: | 2019-05-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | 15-deoxy-Delta12,14-Prostaglandin J2inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Commun Biol, 2, 2019
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6I5E
 | | X-ray structure of apo human soluble Epoxide Hydrolase C-terminal Domain (hsEH CTD) | | Descriptor: | Bifunctional epoxide hydrolase 2 | | Authors: | Abis, G, Kopec, J, Yue, W.W, Conte, M.R. | | Deposit date: | 2018-11-13 | | Release date: | 2019-05-29 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | 15-deoxy-Delta12,14-Prostaglandin J2inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Commun Biol, 2, 2019
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2MTG
 | | Solution structure of the RRM1 of human LARP6 | | Descriptor: | La-related protein 6 | | Authors: | Martino, L, Atkinson, A.R, Kelly, G, Conte, M.R. | | Deposit date: | 2014-08-18 | | Release date: | 2014-12-24 | | Last modified: | 2015-01-28 | | Method: | SOLUTION NMR | | Cite: | Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
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2MTF
 | | Solution structure of the La motif of human LARP6 | | Descriptor: | La-related protein 6 | | Authors: | Martino, L, Salisbury, N.JH, Atkinson, A.R, Kelly, G, Conte, M.R. | | Deposit date: | 2014-08-18 | | Release date: | 2014-12-24 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.
Nucleic Acids Res., 43, 2015
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2VON
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU | | Descriptor: | 5'-R(*AP*UP*AP*AP*UP*UP*UP)-3', LUPUS LA PROTEIN | | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | Deposit date: | 2008-02-19 | | Release date: | 2008-05-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2VOD
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU | | Descriptor: | 5'-R(*AP*UP*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN | | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | Deposit date: | 2008-02-15 | | Release date: | 2008-05-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2VOP
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU | | Descriptor: | 5'-R(*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN, SULFATE ION | | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | Deposit date: | 2008-02-19 | | Release date: | 2008-05-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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2VOO
 | | Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU | | Descriptor: | 5'-R(*UP*UP*UP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN | | Authors: | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | | Deposit date: | 2008-02-19 | | Release date: | 2008-05-06 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein.
Structure, 16, 2008
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1S7A
 | | NMR structure of the La motif of human La protein | | Descriptor: | Lupus La protein | | Authors: | Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R. | | Deposit date: | 2004-01-29 | | Release date: | 2004-04-06 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
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1S79
 | | Solution structure of the central RRM of human La protein | | Descriptor: | Lupus La protein | | Authors: | Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R. | | Deposit date: | 2004-01-29 | | Release date: | 2004-04-06 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
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2KFW
 | | Solution structure of full-length SlyD from E.coli | | Descriptor: | FKBP-type peptidyl-prolyl cis-trans isomerase slyD | | Authors: | Martino, L, He, Y, Hands-Taylor, K.L, Valentine, E.R, Kelly, G, Giancola, C, Conte, M.R. | | Deposit date: | 2009-02-28 | | Release date: | 2009-09-15 | | Last modified: | 2020-02-26 | | Method: | SOLUTION NMR | | Cite: | The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity.
Febs J., 276, 2009
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1OWX
 | | Solution structure of the C-terminal RRM of human La (La225-334) | | Descriptor: | Lupus La protein | | Authors: | Jacks, A, Babon, J, Kelly, G, Manolaridis, I, Cary, P.D, Curry, S, Conte, M.R. | | Deposit date: | 2003-03-31 | | Release date: | 2003-07-29 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element
Structure, 11, 2003
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1SJR
 | | NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) | | Descriptor: | Polypyrimidine tract-binding protein 1 | | Authors: | Simpson, P.J, Monie, T.P, Szendroi, A, Davydova, N, Tyzack, J.K, Conte, M.R, Read, C.M, Cary, P.D, Svergun, D.I, Konarev, P.V, Petoukhov, M.V, Curry, S, Matthews, S.J. | | Deposit date: | 2004-03-04 | | Release date: | 2004-09-14 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Structure, 12, 2004
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1SJQ
 | | NMR Structure of RRM1 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1) | | Descriptor: | Polypyrimidine tract-binding protein 1 | | Authors: | Simpson, P.J, Monie, T.P, Szendroi, A, Davydova, N, Tyzack, J.K, Conte, M.R, Read, C.M, Cary, P.D, Svergun, D.I, Konarev, P.V, Petoukhov, M.V, Curry, S, Matthews, S.J. | | Deposit date: | 2004-03-04 | | Release date: | 2004-09-14 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Structure, 12, 2004
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6GJ4
 | | Tubulin-6j complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-(quinolin-5-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate, CALCIUM ION, ... | | Authors: | Brindisi, M, Ulivieri, C, Alfano, G, Gemma, S, Balaguer, F.d.A, Khan, T, Grillo, A, Chemi, G, Menchon, G, Prota, A.E, Olieric, N, Agell, D.L, Barasoain, I, Diaz, J.F, Nebbioso, A, Conte, M.R, Lopresti, L, Magnano, S, Amet, R, Kinsella, P, Zisterer, D.M, Ibrahim, O, O'Sullivan, J, Morbidelli, L, Spaccapelo, R, Baldari, C, Butini, S, Novellino, E, Campiani, G, Altucci, L, Steinmetz, M.O, Brogi, S. | | Deposit date: | 2018-05-16 | | Release date: | 2018-12-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents.
Eur J Med Chem, 162, 2018
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4CPG
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5IFM
 | | Human NONO (p54nrb) Homodimer | | Descriptor: | CHLORIDE ION, GLYCEROL, Non-POU domain-containing octamer-binding protein, ... | | Authors: | Knott, G.J, Bond, C.S. | | Deposit date: | 2016-02-26 | | Release date: | 2016-11-09 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry.
Acta Crystallogr D Struct Biol, 72, 2016
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6Y7Y
 | | Fragments KCL_771 and KCL_802 in complex with MAP kinase p38-alpha | | Descriptor: | (2-azanyl-2-adamantyl)methanol, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, 6-[2,5-bis(oxidanylidene)pyrrolidin-1-yl]pyridine-3-sulfonamide, ... | | Authors: | De Nicola, G.F, Nichols, C.E. | | Deposit date: | 2020-03-02 | | Release date: | 2020-03-11 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
J.Med.Chem., 63, 2020
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