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4P48
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BU of 4p48 by Molmil
The structure of a chicken anti-cardiac Troponin I scFv
Descriptor: Antibody scFv 180
Authors:Conroy, P.J, Law, R.H.P, Gillgunn, S, Hearty, S, Caradoc-Davies, T.T, Llyod, G, O'Kennedy, R.J, Whisstock, J.C.
Deposit date:2014-03-12
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Reconciling the structural attributes of avian antibodies.
J.Biol.Chem., 289, 2014
4P49
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BU of 4p49 by Molmil
The structure of a chicken anti-prostate specific antigen scFv
Descriptor: ACETATE ION, Antibody scFv B8, SULFATE ION
Authors:Conroy, P.J, Law, R.H.P, Gilgunn, S, Hearty, S, Llyod, G, Caradoc-Davies, T.T, O'Kennedy, R.J, Whisstock, J.C.
Deposit date:2014-03-12
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Reconciling the structural attributes of avian antibodies.
J.Biol.Chem., 289, 2014
4Y1S
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BU of 4y1s by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.611 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
4Y1T
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BU of 4y1t by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.666 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
5FMW
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BU of 5fmw by Molmil
The poly-C9 component of the Complement Membrane Attack Complex
Descriptor: POLYC9
Authors:Dudkina, N.V, Spicer, B.A, Reboul, C.F, Conroy, P.J, Lukoyanova, N, Elmlund, H, Law, R.H.P, Ekkel, S.M, Kondos, S.C, Goode, R.J.A, Ramm, G, Whisstock, J.C, Saibil, H.R, Dunstone, M.A.
Deposit date:2015-11-10
Release date:2016-02-17
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Structure of the Poly-C9 Component of the Complement Membrane Attack Complex
Nat.Commun., 7, 2016
5UG6
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BU of 5ug6 by Molmil
Perforin C2 Domain - T431D
Descriptor: IODIDE ION, Perforin-1
Authors:Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
5UG7
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BU of 5ug7 by Molmil
Calcium bound Perforin C2 Domain - T431D
Descriptor: CALCIUM ION, Perforin-1
Authors:Law, R.H.P, Conroy, P.J, Voskoboinik, I, Whisstock, J.C.
Deposit date:2017-01-07
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death Differ., 25, 2018
5VFY
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BU of 5vfy by Molmil
Structure of an accessory protein of the pCW3 relaxosome
Descriptor: TcpK
Authors:Traore, D.A.K, Wisniewski, J.A, Flanigan, S.F, Conroy, P.J, Panjikar, S, Mok, Y.-F, Lao, C, Griffin, M.D.W, Adams, V, Rood, J.I, Whisstock, J.C.
Deposit date:2017-04-10
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3.
Nat Commun, 9, 2018
5VFX
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Structure of an accessory protein of the pCW3 relaxosome in complex with the origin of transfer (oriT) DNA
Descriptor: TcpK, oriT
Authors:Traore, D.A.K, Wisniewski, J.A, Flanigan, S.F, Conroy, P.J, Panjikar, S, Mok, Y.-F, Lao, C, Griffin, M.D.W, Adams, V, Rood, J.I, Whisstock, J.C.
Deposit date:2017-04-10
Release date:2018-04-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3.
Nat Commun, 9, 2018
8DZV
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BU of 8dzv by Molmil
Chicken anti-cardiac Troponin I antibody in complex with peptide
Descriptor: PHOSPHATE ION, POTASSIUM ION, cTnI peptide, ...
Authors:Conroy, P.J, Law, H.P.
Deposit date:2022-08-08
Release date:2023-07-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Design of Polarity-Dependent Immunosensors Based on the Structural Analysis of Engineered Antibodies.
Acs Chem.Biol., 18, 2023
6RSY
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BU of 6rsy by Molmil
The complex between TCR a7b2 and human Class I MHC HLA-A0201-WT1 with the bound RMFPNAPYL peptide.
Descriptor: 1,2-ETHANEDIOL, ARG-MET-PHE-PRO-ASN-ALA-PRO-TYR-LEU, Beta-2-microglobulin, ...
Authors:Srikannathasan, V, Robinson, R.A.
Deposit date:2019-05-22
Release date:2020-04-15
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
J.Clin.Invest., 130, 2020
6NMB
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BU of 6nmb by Molmil
Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator
Descriptor: NITRATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, Urokinase-type plasminogen activator
Authors:Law, R.H.P, Wu, G.
Deposit date:2019-01-10
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.
Blood Adv, 3, 2019
6OG4
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BU of 6og4 by Molmil
plasminogen binding group A streptococcal M protein
Descriptor: Plasminogen, Plasminogen-binding group A streptococcal M-like protein PAM, SULFATE ION
Authors:Law, R.H.P, Quek, A.J, Whisstock, J.C, Caradoc-Davies, T.T.
Deposit date:2019-04-01
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
J.Mol.Biol., 431, 2019
6CXO
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BU of 6cxo by Molmil
Complement component-9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement component C9, ...
Authors:Law, R.H.P, Spicer, B.A, Caradoc-Davies, T.T.
Deposit date:2018-04-03
Release date:2018-09-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
6DLW
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BU of 6dlw by Molmil
Complement component polyC9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement component C9, beta-D-mannopyranose
Authors:Dunstone, M.A, Spicer, B.A, Law, R.H.P.
Deposit date:2018-06-03
Release date:2018-09-12
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
5HN1
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BU of 5hn1 by Molmil
Crystal structure of Interleukin-37
Descriptor: Interleukin-37, SULFATE ION
Authors:Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C.
Deposit date:2016-01-17
Release date:2017-02-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Sci Immunol, 2, 2017
5J7C
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BU of 5j7c by Molmil
A picomolar affinity FN3 domain in complex with hen egg-white lysozyme
Descriptor: FNfn10-anti-lysozyme (DE0.4.1), Lysozyme C
Authors:Porebski, B.T, Drinkwater, N, McGowan, S, Buckle, A.M.
Deposit date:2016-04-06
Release date:2016-08-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.535 Å)
Cite:Circumventing the stability-function trade-off in an engineered FN3 domain.
Protein Eng.Des.Sel., 2016
5J7K
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BU of 5j7k by Molmil
Loop grafting onto a highly stable FN3 scaffold
Descriptor: FN3con-a-lys, ZINC ION
Authors:Porebski, B.T, Drinkwater, N, McGowan, S, Buckle, A.M.
Deposit date:2016-04-06
Release date:2016-08-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Circumventing the stability-function trade-off in an engineered FN3 domain.
Protein Eng.Des.Sel., 2016
6U2J
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BU of 6u2j by Molmil
EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.37 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2W
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BU of 6u2w by Molmil
EM structure of MPEG-1(L425K) pre-pore complex bound to liposome
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U23
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BU of 6u23 by Molmil
EM structure of MPEG-1(w.t.) soluble pre-pore
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-19
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2L
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BU of 6u2l by Molmil
EM structure of MPEG-1 (L425K, beta conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2K
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BU of 6u2k by Molmil
EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein
Authors:Pang, S.S, Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
5UGG
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BU of 5ugg by Molmil
Protease Inhibitor
Descriptor: Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide, Plasminogen
Authors:Law, R.H.P, Wu, G, Whisstock, J.C.
Deposit date:2017-01-08
Release date:2017-05-31
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
5UGD
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BU of 5ugd by Molmil
Protease Inhibitor
Descriptor: Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(pyridin-4-yl)methyl]-L-tyrosinamide, Plasminogen
Authors:Law, R.H.P, Wu, G, Whisstock, J.C.
Deposit date:2017-01-08
Release date:2017-05-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017

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