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1HC8
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BU of 1hc8 by Molmil
CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX
Descriptor: 58 NUCLEOTIDE RIBOSOMAL 23S RNA DOMAIN, MAGNESIUM ION, OSMIUM ION, ...
Authors:Conn, G.L, Draper, D.E, Lattman, E.E, Gittis, A.G.
Deposit date:2001-04-27
Release date:2002-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A Compact RNA Tertiary Structure Contains a Buried Backbone-K+ Complex
J.Mol.Biol., 318, 2002
1QA6
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BU of 1qa6 by Molmil
CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX
Descriptor: 58 NUCLEOTIDE RIBOSOMAL RNA DOMAIN, MAGNESIUM ION, OSMIUM ION, ...
Authors:Conn, G.L, Draper, D.E, Lattman, E.E, Gittis, A.G.
Deposit date:1999-04-15
Release date:1999-05-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a conserved ribosomal protein-RNA complex.
Science, 284, 1999
6PRV
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BU of 6prv by Molmil
58nt RNA L11-binding domain from E. coli 23S rRNA
Descriptor: 23S rRNA, MAGNESIUM ION, POTASSIUM ION
Authors:Conn, G.L, Dunstan, M.S.
Deposit date:2019-07-11
Release date:2020-01-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain.
J.Mol.Biol., 432, 2020
1AXP
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BU of 1axp by Molmil
DNA DUPLEX CONTAINING A PURINE-RICH STRAND, NMR, 6 STRUCTURES
Descriptor: DNA (D(GAAGAGAAGC)(DOT)D(GCTTCTCTTC))
Authors:Gyi, J.I, Lane, A.N, Conn, G.L, Brown, T.
Deposit date:1997-10-17
Release date:1998-04-22
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes.
Biochemistry, 37, 1998
7S0S
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BU of 7s0s by Molmil
M. tuberculosis ribosomal RNA methyltransferase TlyA bound to M. smegmatis 50S ribosomal subunit
Descriptor: 16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA, 23S rRNA, 50S ribosomal protein L10, ...
Authors:Laughlin, Z.T, Dunham, C.M, Conn, G.L.
Deposit date:2021-08-31
Release date:2022-03-30
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
Proc.Natl.Acad.Sci.USA, 119, 2022
4X1O
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BU of 4x1o by Molmil
Crystal structure of the 16S rRNA (adenine(1408)-N(1))-methyltransferase from Catenulisporales acidiphilia
Descriptor: 16S rRNA (adenine(1408)-N(1))-methyltransferase
Authors:Witek, M.A, Conn, G.L.
Deposit date:2014-11-25
Release date:2015-11-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization.
Nucleic Acids Res., 44, 2016
1AL5
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BU of 1al5 by Molmil
A-TRACT RNA DODECAMER, NMR, 12 STRUCTURES
Descriptor: RNA (5'-R(*CP*GP*CP*AP*AP*AP*UP*UP*UP*GP*CP*G)-3')
Authors:Conte, M.R, Conn, G.L, Brown, T, Lane, A.N.
Deposit date:1997-06-11
Release date:1997-12-17
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Conformational properties and thermodynamics of the RNA duplex r(CGCAAAUUUGCG)2: comparison with the DNA analogue d(CGCAAATTTGCG)2.
Nucleic Acids Res., 25, 1997
7JLZ
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BU of 7jlz by Molmil
Crystal structure of 30S ribosomal A1408 methyltransferase from an uncultured bacterium (UncKam)
Descriptor: 16S rRNA methylase, SULFATE ION
Authors:Nosrati, M, Conn, G.L.
Deposit date:2020-07-30
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Roles of conserved tryptophans in substrate recognition and catalysis by the aminoglycoside-resistance 16S rRNA (m1A1408) rRNA methyltransferases
To be published
1DRR
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BU of 1drr by Molmil
DNA/RNA HYBRID DUPLEX CONTAINING A PURINE-RICH DNA STRAND, NMR, 10 STRUCTURES
Descriptor: DNA (5'-D(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3'), RNA (5'-R(*GP*CP*UP*UP*CP*UP*CP*UP*UP*C)-3')
Authors:Gyi, J.I, Lane, A.N, Conn, G.L, Brown, T.
Deposit date:1997-10-21
Release date:1998-04-22
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes.
Biochemistry, 37, 1998
8GHU
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BU of 8ghu by Molmil
Methyltransferase RmtC bound to the 30S ribosomal subunit
Descriptor: 16S rRNA, 16S rRNA (guanine(1405)-N(7))-methyltransferase, 30S ribosomal protein S12, ...
Authors:Srinivas, P, Conn, G.L, Dunham, C.M.
Deposit date:2023-03-12
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3 Å)
Cite:30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.
Biorxiv, 2023
6PQB
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BU of 6pqb by Molmil
Crystal structure of aminoglycoside-resistance methyltransferase RmtC bound to S-adenosylhomocysteine (SAH)
Descriptor: 16S rRNA (guanine(1405)-N(7))-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Nosrati, M, Hoffer, E.D, Conn, G.L.
Deposit date:2019-07-08
Release date:2019-10-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition.
J.Biol.Chem., 294, 2019
5KS2
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BU of 5ks2 by Molmil
RAWV_CTD (Helix form) of 16S/23S 2'-O-methyltransferase TlyA
Descriptor: 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA, CHLORIDE ION
Authors:Kuiper, E.G, Conn, G.L.
Deposit date:2016-07-07
Release date:2017-01-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis.
J. Biol. Chem., 292, 2017
5KYG
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BU of 5kyg by Molmil
RAWV_CTD (Loop Structure) of 16S/23S 2'-O-methyltransferase TlyA
Descriptor: Cytotoxin / haemolysin homologue TlyA, GLYCEROL
Authors:Kuiper, E.G, Conn, G.L.
Deposit date:2016-07-21
Release date:2017-01-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis.
J. Biol. Chem., 292, 2017
2O9U
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BU of 2o9u by Molmil
Monellin (MNEI) at 1.15 resolution
Descriptor: Monellin chain B and Monellin chain A, SULFATE ION
Authors:Hobbs, J.R, Munger, S.D, Conn, G.L.
Deposit date:2006-12-14
Release date:2007-02-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Monellin (MNEI) at 1.15 A resolution
Acta Crystallogr.,Sect.F, 63, 2007
3GYQ
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BU of 3gyq by Molmil
Structure of the Thiostrepton-Resistance Methyltransferase S-adenosyl-L-methionine Complex
Descriptor: S-ADENOSYLMETHIONINE, rRNA (adenosine-2'-O-)-methyltransferase
Authors:Dunstan, M.S, Conn, G.L.
Deposit date:2009-04-04
Release date:2009-04-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of the thiostrepton-resistance methyltransferase-S-adenosyl-L-methionine complex and its interaction with ribosomal RNA
J.Biol.Chem., 284, 2009
1Y39
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BU of 1y39 by Molmil
Co-evolution of protein and RNA structures within a highly conserved ribosomal domain
Descriptor: 50S ribosomal protein L11, 58 Nucleotide Ribosomal 23S RNA Domain, COBALT (III) ION, ...
Authors:Dunstan, M.S, GuhaThakurta, D, Draper, D.E, Conn, G.L.
Deposit date:2004-11-24
Release date:2005-03-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Coevolution of Protein and RNA Structures within a Highly Conserved Ribosomal Domain
Chem.Biol., 12, 2005
1OO7
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BU of 1oo7 by Molmil
DNA.RNA HYBRID DUPLEX CONTAINING A 5-PROPYNE DNA STRAND AND PURINE-RICH RNA STRAND, NMR, 4 STRUCTURES
Descriptor: 5'-D(*GP*(5PC)P*(PDU)P*(PDU)P*(5PC)P*(PDU)P*(5PC)P*(PDU)P*(PDU)P*C)-3', 5'-R(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3'
Authors:Gyi, J.I, Gao, D, Conn, G.L, Trent, J.O, Brown, T, Lane, A.N.
Deposit date:2003-03-03
Release date:2003-11-11
Last modified:2021-07-28
Method:SOLUTION NMR
Cite:The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications
Nucleic Acids Res., 31, 2003
1RRD
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BU of 1rrd by Molmil
DNA/RNA HYBRID DUPLEX CONTAINING A PURINE-RICH RNA STRAND, NMR, 10 STRUCTURES
Descriptor: DNA (5'-D(*GP*CP*TP*TP*CP*TP*CP*TP*TP*C)-3'), RNA (5'-R(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3')
Authors:Gyi, J.I, Lane, A.N, Conn, G.L, Brown, T.
Deposit date:1997-10-21
Release date:1998-04-22
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes.
Biochemistry, 37, 1998
1RRR
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BU of 1rrr by Molmil
RNA DUPLEX CONTAINING A PURINE-RICH STRAND, NMR, 10 STRUCTURES
Descriptor: RNA (5'-R(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3'), RNA (5'-R(*GP*CP*UP*UP*CP*UP*CP*UP*UP*C)-3')
Authors:Gyi, J.I, Lane, A.N, Conn, G.L, Brown, T.
Deposit date:1997-10-21
Release date:1998-04-22
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structures of DNA.RNA hybrids with purine-rich and pyrimidine-rich strands: comparison with the homologous DNA and RNA duplexes.
Biochemistry, 37, 1998
3MTE
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BU of 3mte by Molmil
Crystal Structure of 16S rRNA Methyltranferase
Descriptor: 16S rRNA methylase, S-ADENOSYLMETHIONINE
Authors:Macmaster, R.A, Conn, G.L, Zelinskaya, N.
Deposit date:2010-04-30
Release date:2010-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria.
Nucleic Acids Res., 38, 2010
3PXM
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BU of 3pxm by Molmil
Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix
Descriptor: Monellin chain B/Monellin chain A chimeric protein
Authors:Hobbs, J.R, Templeton, C.M, Pour, S.O, Blanch, E.W, Munger, S.M, Conn, G.L.
Deposit date:2010-12-10
Release date:2011-04-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Reduced Sweetness of a Monellin (MNEI) Mutant Results from Increased Protein Flexibility and Disruption of a Distant Poly-(L-Proline) II Helix.
Chem Senses, 36, 2011
3Q2P
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BU of 3q2p by Molmil
Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix
Descriptor: Monellin chain B/Monellin chain A chimeric protein, SODIUM ION
Authors:Templeton, C.M, Hobbs, J.R, Munger, S.D, Conn, G.L.
Deposit date:2010-12-20
Release date:2011-04-06
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.341 Å)
Cite:Reduced Sweetness of a Monellin (MNEI) Mutant Results from Increased Protein Flexibility and Disruption of a Distant Poly-(L-Proline) II Helix.
Chem Senses, 36, 2011
5BW5
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BU of 5bw5 by Molmil
Crystal structure of the 16S rRNA (adenine(1408)-N(1))-methyltransferase D21A mutant from Catenulisporales acidiphilia
Descriptor: 16S rRNA (adenine(1408)-N(1))-methyltransferase
Authors:Witek, M.A, Conn, G.L.
Deposit date:2015-06-05
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization.
Nucleic Acids Res., 44, 2016
5BW4
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BU of 5bw4 by Molmil
Crystal structure of the 16S rRNA (adenine(1408)-N(1))-methyltransferase W203A mutant with cosubstrate SAM from Catenulisporales acidiphilia
Descriptor: 16S rRNA (adenine(1408)-N(1))-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Witek, M.A, Conn, G.L.
Deposit date:2015-06-05
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization.
Nucleic Acids Res., 44, 2016
5D1H
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BU of 5d1h by Molmil
Crystal structure of the 16S rRNA (adenine(1408)-N(1))-methyltransferase W203A mutant from Catenulisporales acidiphilia
Descriptor: Uncharacterized protein
Authors:Witek, M.A, Conn, G.L.
Deposit date:2015-08-04
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Functional dichotomy in the 16S rRNA (m1A1408) methyltransferase family and control of catalytic activity via a novel tryptophan mediated loop reorganization.
Nucleic Acids Res., 44, 2016

 

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