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6B1G
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Solution structure of TDP-43 N-terminal domain dimer.
Descriptor: TAR DNA-binding protein 43, S48E Mutant, Y4R Mutant
Authors:Naik, M.T, Wang, A, Conicella, A, Fawzi, N.L.
Deposit date:2017-09-18
Release date:2018-02-28
Last modified:2020-01-01
Method:SOLUTION NMR
Cite:A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.
EMBO J., 37, 2018

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