Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6BUU
DownloadVisualize
BU of 6buu by Molmil
Crystal structure of AKT1 (aa 144-480) with a bisubstrate
Descriptor: GLY-ARG-PRO-ARG-THR-THR-ZXW-PHE-ALA-GLU, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ...
Authors:Chu, N, Gabelli, S.B, Cole, P.A.
Deposit date:2017-12-11
Release date:2018-08-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Cell, 174, 2018
7MYX
DownloadVisualize
BU of 7myx by Molmil
Crystal structure of the PH domain (R86A) of Akt1
Descriptor: RAC-alpha serine/threonine-protein kinase
Authors:Bae, H, Park, E, Cole, P.A, Eck, M.J.
Deposit date:2021-05-22
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:PH domain-mediated autoinhibition and oncogenic activation of Akt.
Elife, 11, 2022
6NPZ
DownloadVisualize
BU of 6npz by Molmil
Crystal structure of Akt1 (aa 123-480) kinase with a bisubstrate
Descriptor: GLYCEROL, MANGANESE (II) ION, RAC-alpha serine/threonine-protein kinase, ...
Authors:Chu, N, Cole, P.A, Gabelli, S.B.
Deposit date:2019-01-18
Release date:2019-01-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.
Cell, 174, 2018
1KUV
DownloadVisualize
BU of 1kuv by Molmil
X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition
Descriptor: COA-S-ACETYL 5-BROMOTRYPTAMINE, MAGNESIUM ION, Serotonin N-acetyltransferase
Authors:Wolf, E, De Angelis, J, Khalil, E.M, Cole, P.A, Burley, S.K.
Deposit date:2002-01-22
Release date:2002-03-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.
J.Mol.Biol., 317, 2002
1KUX
DownloadVisualize
BU of 1kux by Molmil
X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition
Descriptor: COA-S-TRIMETHYLENE-ACETYL-TRYPTAMINE, Serotonin N-acetyltransferase
Authors:Wolf, E, De Angelis, J, Khalil, E.M, Cole, P.A, Burley, S.K.
Deposit date:2002-01-22
Release date:2002-03-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.
J.Mol.Biol., 317, 2002
1KUY
DownloadVisualize
BU of 1kuy by Molmil
X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition
Descriptor: COA-S-ACETYL TRYPTAMINE, Serotonin N-acetyltransferase
Authors:Wolf, E, De Angelis, J, Khalil, E.M, Cole, P.A, Burley, S.K.
Deposit date:2002-01-22
Release date:2002-03-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.
J.Mol.Biol., 317, 2002
1L0C
DownloadVisualize
BU of 1l0c by Molmil
Investigation of the Roles of Catalytic Residues in Serotonin N-Acetyltransferase
Descriptor: COA-S-ACETYL TRYPTAMINE, Serotonin N-acetyltransferase
Authors:Scheibner, K.A, De Angelis, J, Burley, S.K, Cole, P.A.
Deposit date:2002-02-08
Release date:2002-06-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Investigation of the roles of catalytic residues in serotonin N-acetyltransferase.
J.Biol.Chem., 277, 2002
1M1D
DownloadVisualize
BU of 1m1d by Molmil
TETRAHYMENA GCN5 WITH BOUND BISUBSTRATE ANALOG INHIBITOR
Descriptor: HISTONE H3, TGCN5 HISTONE ACETYL TRANSFERASE
Authors:Poux, A.N, Cebrat, M, Kim, C.M, Cole, P.A, Marmorstein, R.
Deposit date:2002-06-18
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor.
Proc.Natl.Acad.Sci.USA, 99, 2002
3D7T
DownloadVisualize
BU of 3d7t by Molmil
Structural basis for the recognition of c-Src by its inactivator Csk
Descriptor: Proto-oncogene tyrosine-protein kinase Src, STAUROSPORINE, Tyrosine-protein kinase CSK
Authors:Levinson, N.M, Seeliger, M.A, Cole, P.A, Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3D7U
DownloadVisualize
BU of 3d7u by Molmil
Structural basis for the recognition of c-Src by its inactivator Csk
Descriptor: Proto-oncogene tyrosine-protein kinase Src, Tyrosine-protein kinase CSK
Authors:Levinson, N.M, Seeliger, M.A, Cole, P.A, Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (4.111 Å)
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3GEQ
DownloadVisualize
BU of 3geq by Molmil
Structural basis for the chemical rescue of Src kinase activity
Descriptor: 1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Proto-oncogene tyrosine-protein kinase Src
Authors:Muratore, K.E, Seeliger, M.A, Wang, Z, Fomina, D, Neiswinger, J, Havranek, J.J, Baker, D, Kuriyan, J, Cole, P.A.
Deposit date:2009-02-25
Release date:2009-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry, 48, 2009
3BIY
DownloadVisualize
BU of 3biy by Molmil
Crystal structure of p300 histone acetyltransferase domain in complex with a bisubstrate inhibitor, Lys-CoA
Descriptor: BROMIDE ION, Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate
Authors:Liu, X, Wang, L, Zhao, K, Thompson, P.R, Hwang, Y, Marmorstein, R, Cole, P.A.
Deposit date:2007-12-02
Release date:2008-02-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
Nature, 451, 2008
2CCH
DownloadVisualize
BU of 2cch by Molmil
The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION CONTROL PROTEIN 6 HOMOLOG, CELL DIVISION PROTEIN KINASE 2, ...
Authors:Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Role of the Phospho-Cdk2/Cyclin a Recruitment Site in Substrate Recognition
J.Biol.Chem., 281, 2006
2CCI
DownloadVisualize
BU of 2cci by Molmil
Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 6 homolog, Cyclin-A2, ...
Authors:Cheng, K.Y, Noble, M.E.M, Skamnaki, V, Brown, N.R, Lowe, E.D, Kontogiannis, L, Shen, K, Cole, P.A, Siligardi, G, Johnson, L.N.
Deposit date:2006-01-16
Release date:2006-05-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
J. Biol. Chem., 281, 2006
2GS6
DownloadVisualize
BU of 2gs6 by Molmil
Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate
Descriptor: CHLORIDE ION, Epidermal growth factor receptor, Peptide, ...
Authors:Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
Cell(Cambridge,Mass.), 125, 2006
2GS7
DownloadVisualize
BU of 2gs7 by Molmil
Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP
Descriptor: Epidermal growth factor receptor, IODIDE ION, MAGNESIUM ION, ...
Authors:Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Cell(Cambridge,Mass.), 125, 2006
2GS2
DownloadVisualize
BU of 2gs2 by Molmil
Crystal Structure of the active EGFR kinase domain
Descriptor: Epidermal growth factor receptor
Authors:Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J.
Deposit date:2006-04-25
Release date:2006-06-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell(Cambridge,Mass.), 125, 2006
4PFJ
DownloadVisualize
BU of 4pfj by Molmil
The structure of bi-acetylated SAHH
Descriptor: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J.
Deposit date:2014-04-29
Release date:2014-10-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
4PGF
DownloadVisualize
BU of 4pgf by Molmil
The structure of mono-acetylated SAHH
Descriptor: ADENOSINE, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Kavran, J.M, Wang, Y, Cole, P.A, Leahy, D.J.
Deposit date:2014-05-01
Release date:2014-10-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Regulation of s-adenosylhomocysteine hydrolase by lysine acetylation.
J.Biol.Chem., 289, 2014
2RFD
DownloadVisualize
BU of 2rfd by Molmil
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor, SULFATE ION
Authors:Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RF9
DownloadVisualize
BU of 2rf9 by Molmil
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
Authors:Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2RFE
DownloadVisualize
BU of 2rfe by Molmil
Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide
Descriptor: ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor
Authors:Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J.
Deposit date:2007-09-28
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature, 450, 2007
2UXN
DownloadVisualize
BU of 2uxn by Molmil
Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation
Descriptor: CHLORIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Yang, M, Culhane, J.C, Szewczuk, L.M, Gocke, C.B, Brautigam, C.A, Tomchick, D.R, Machius, M, Cole, P.A, Yu, H.
Deposit date:2007-03-28
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural Basis of Histone Demethylation by Lsd1 Revealed by Suicide Inactivation.
Nat.Struct.Mol.Biol., 14, 2007
2UXX
DownloadVisualize
BU of 2uxx by Molmil
Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct
Descriptor: CHLORIDE ION, FAD-trans-2-Phenylcyclopropylamine Adduct, GLYCEROL, ...
Authors:Yang, M, Culhane, J.C, Machius, M, Cole, P.A, Yu, H.
Deposit date:2007-03-30
Release date:2007-08-21
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structural Basis for the Inhibition of the Lsd1 Histone Demethylase by the Antidepressant Trans-2-Phenylcyclopropylamine.
Biochemistry, 46, 2007
1GAG
DownloadVisualize
BU of 1gag by Molmil
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Descriptor: BISUBSTRATE PEPTIDE INHIBITOR, INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, ...
Authors:Parang, K, Till, J.H, Ablooglu, A.J, Kohanski, R.A, Hubbard, S.R, Cole, P.A.
Deposit date:2000-11-29
Release date:2001-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001

 

123>

217157

PDB entries from 2024-03-13

PDB statisticsPDBj update infoContact PDBjnumon