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6BX8
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BU of 6bx8 by Molmil
Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C)
Descriptor: SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3
Authors:Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S.
Deposit date:2017-12-18
Release date:2019-02-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J. Biol. Chem., 294, 2019
6HAR
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BU of 6har by Molmil
Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C
Descriptor: 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ...
Authors:Shahar, A, Cohen, I, Radisky, E, Papo, N.
Deposit date:2018-08-08
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin.
J.Biol.Chem., 294, 2019
6GFI
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BU of 6gfi by Molmil
Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V
Descriptor: 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein
Authors:Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S.
Deposit date:2018-04-30
Release date:2018-09-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.
Nat Commun, 9, 2018
5C67
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BU of 5c67 by Molmil
Human Mesotrypsin in complex with amyloid precursor protein inhibitor variant APPI-M17G/I18F/F34V
Descriptor: Amyloid beta A4 protein, Trypsin-3
Authors:Kayode, O, Sankaran, B, Radisky, E.S.
Deposit date:2015-06-22
Release date:2016-05-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.
Biochem.J., 473, 2016
5JBT
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BU of 5jbt by Molmil
Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2)
Descriptor: Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ...
Authors:Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S.
Deposit date:2016-04-13
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis.
J. Biol. Chem., 291, 2016
5NX1
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BU of 5nx1 by Molmil
Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy
Descriptor: Amyloid-beta A4 protein, Kallikrein-6
Authors:Shahar, A, Sananes, A, Radisky, E.S, Papo, N.
Deposit date:2017-05-09
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.853 Å)
Cite:A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018
5NX3
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BU of 5nx3 by Molmil
Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy
Descriptor: Amyloid-beta A4 protein, Kallikrein-6
Authors:Shahar, A, Sananes, A, Radisky, E.S, Papo, N.
Deposit date:2017-05-09
Release date:2018-05-30
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.296 Å)
Cite:A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
J.Biol.Chem., 293, 2018

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