Author results

5W98
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PYRIDINE SYNTHASE, PBTD, FROM GE2270 BIOSYNTHESIS
Descriptor:PbtD, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2017-06-22
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5W99
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PYRIDINE SYNTHASE, PBTD, FROM GE2270 BIOSYNTHESIS BOUND TO TSP
Descriptor:PbtD, 2,2'-(6-(2'-(aminomethyl)-[2,4'-bithiazol]-4-yl)pyridine-2,5-diyl)bis(thiazole-4-carboxylic acid), SULFATE ION
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2017-06-22
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WA3
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PYRIDINE SYNTHASE, TBTD, FROM THIOMURACIN BIOSYNTHESIS
Descriptor:Pyridine synthase TbtD
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2017-06-24
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WA4
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PYRIDINE SYNTHASE, TBTD, FROM THIOMURACIN BIOSYNTHESIS BOUND TO AN N-TERMINAL LEADER PEPTIDE FRAGMENT
Descriptor:Pyridine synthase TbtD, TbtA 16-mer peptide
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2017-06-24
Release date:2017-11-22
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (2.646 Å)
Cite:Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6C28
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TRANSCRIPTIONAL REPRESSOR, COUR, BOUND TO P-COUMAROYL-COA
Descriptor:Transcriptional regulator, MarR family, p-coumaroyl-CoA
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-01-07
Release date:2018-05-30
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris.
J. Biol. Chem., 293, 2018
6C2S
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TRANSCRIPTIONAL REPRESSOR, COUR, BOUND TO A 23-MER DNA DUPLEX
Descriptor:Transcriptional regulator, MarR family, 23-mer
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-01-08
Release date:2018-05-30
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris.
J. Biol. Chem., 293, 2018
6C9T
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TRANSCRIPTIONAL REPRESSOR, COUR
Descriptor:CouR
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-01-28
Release date:2018-05-30
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural basis of transcriptional regulation by CouR, a repressor of coumarate catabolism, inRhodopseudomonas palustris.
J. Biol. Chem., 293, 2018
6E6T
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DIECKMANN CYCLASE, NCMC, BOUND TO CERULENIN
Descriptor:Dieckmann cyclase, NcmC, (4S,5R)-4,5-dihydroxy-5-[(3E,6E)-octa-3,6-dien-1-yl]pyrrolidin-2-one, ...
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-07-25
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mutation of a conserved scaffold interconverts Dieckmann cyclase and thioesterase activities
To Be Published
6E6U
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VARIANT C89S OF DIECKMANN CYCLASE, NCMC
Descriptor:Dieckmann cyclase, NcmC, SULFATE ION
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-07-25
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Mutation of a conserved scaffold interconverts Dieckmann cyclase and thioesterase activities
To Be Published
6E6Y
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DIECKMANN CYCLASE, NCMC
Descriptor:Dieckmann cyclase, NcmC, SULFATE ION
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-07-25
Release date:2019-07-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mutation of a conserved scaffold interconverts Dieckmann cyclase and thioesterase activities
To Be Published
5UAO
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CRYSTAL STRUCTURE OF MIBH, A LATHIPEPTIDE TRYPTOPHAN 5-HALOGENASE
Descriptor:Tryptophane-5-halogenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2016-12-19
Release date:2017-01-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.
ACS Chem. Biol., 12, 2017
6C0G
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LYSINOALANINE SYNTHASE, DURN, FROM DURAMYCIN BIOSYNTHESIS
Descriptor:Lysinoalanine synthase, POTASSIUM ION
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2017-12-31
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.145 Å)
Cite:Substrate-assisted enzymatic formation of lysinoalanine in duramycin.
Nat. Chem. Biol., 14, 2018
6C0H
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LYSINOALANINE SYNTHASE, DURN, FROM DURAMYCIN BIOSYNTHESIS BOUND TO 1-DHA6ALA
Descriptor:Lysinoalanine synthase, GLN-DAL-CYS-ALA-PHE-GLY-PRO-PHE-DBB-PHE-VAL-CYS-BH2-GLY, POTASSIUM ION
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2017-12-31
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Substrate-assisted enzymatic formation of lysinoalanine in duramycin.
Nat. Chem. Biol., 14, 2018
6C0Y
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LYSINOALANINE SYNTHASE, DURN, FROM DURAMYCIN BIOSYNTHESIS BOUND TO DURAMYCIN
Descriptor:Lysinoalanine synthase, CYS-LYS-GLN-DAL-CYS-ALA-PHE-GLY-PRO-PHE-DBB-PHE-VAL-CYS-BH2-GLY-ASN-DBB-LYS, POTASSIUM ION
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-01-03
Release date:2018-09-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Substrate-assisted enzymatic formation of lysinoalanine in duramycin.
Nat. Chem. Biol., 14, 2018
6EC7
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GLUTAMYLATION DOMAIN, TBTB, FROM THIOMURACIN BIOSYNTHESIS
Descriptor:Lantibiotic dehydratase domain protein
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-08-07
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:TBD
To Be Published
6EC8
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GLUTAMYLATION DOMAIN, TBTB, FROM THIOMURACIN BIOSYNTHESIS BOUND TO 5'-PHOSPHODESMETHYLGLUTAMYCIN
Descriptor:Lantibiotic dehydratase domain protein, 3'-deoxy-3'-[(L-alpha-glutamyl)amino]adenosine 5'-(dihydrogen phosphate)
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-08-07
Release date:2019-06-19
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:TBD
To Be Published
6M7Y
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DEHYDRATASE, NISB, BOUND TO A NON-ELIMINABLE SUBSTRATE ANALOG
Descriptor:Nisin biosynthesis protein NisB, Lantibiotic
Authors:Cogan, D.P., Nair, S.K.
Deposit date:2018-08-21
Release date:2019-08-14
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Characterization of Glutamyl-tRNA Dependent Dehydratases using Non-Reactive Substrate Mimics
Proc.Natl.Acad.Sci.USA, 2019