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6EGS
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BU of 6egs by Molmil
Crystal structure of the GalNAc-T2 F104S mutant in complex with UDP-GalNAc
Descriptor: MANGANESE (II) ION, Polypeptide N-acetylgalactosaminyltransferase 2, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE
Authors:de las Rivas, M, Coelho, H, Diniz, A, Lira-Navarrete, E, Jimenez-Barbero, J, Schjoldager, K.T, Bennett, E.P, Vakhrushev, S.Y, Clausen, H, Corzana, F, Marcelo, F, Hurtado-Guerrero, R.
Deposit date:2017-09-12
Release date:2018-04-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.
Chemistry, 24, 2018
7Q4I
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BU of 7q4i by Molmil
Crystal structure of DmC1GalT1 in complex with UDP-Mn2+ and the APD-TGalNAc-RP
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-galactopyranose, Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, ...
Authors:Gonzalez-Ramirez, A.M, Coelho, H, Companon, I, Grosso, A.S, Yang, Z, Narimatsu, Y, Clausen, H, Marcelo, F, Corzana, F, Hurtado-Guerrero, R.
Deposit date:2021-10-31
Release date:2022-04-13
Last modified:2022-11-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the synthesis of the core 1 structure by C1GalT1.
Nat Commun, 13, 2022
6H0B
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BU of 6h0b by Molmil
Crystal structure of the human GalNAc-T4 in complex with UDP, manganese and the diglycopeptide 6.
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO-GLY, ...
Authors:de las Rivas, M, Daniel, E.J.P, Coelho, H, Lira-Navarrete, E, Raich, L, Companon, I, Diniz, A, Lagartera, L, Jimenez-Barbero, J, Clausen, H, Rovira, C, Marcelo, F, Corzana, F, Gerken, T.A, Hurtado-Guerrero, R.
Deposit date:2018-07-08
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.
ACS Cent Sci, 4, 2018
5NQA
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BU of 5nqa by Molmil
Crystal structure of GalNAc-T4 in complex with the monoglycopeptide 3
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose, GLYCEROL, ...
Authors:de las Rivas, M, Lira-Navarrete, E, Daniel, E.J.P, Companon, I, Coelho, H, Diniz, A, Jimenez-Barbero, J, Peregrina, J.M, Clausen, H, Corzana, F, Marcelo, F, Jimenez-Oses, G, Gerken, T.A, Hurtado-Guerrero, R.
Deposit date:2017-04-19
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.
Nat Commun, 8, 2017
6S24
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BU of 6s24 by Molmil
Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and the peptide 3
Descriptor: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO, ...
Authors:de las Rivas, M, Daniel, E.J.P, Narimatsu, Y, Companon, I, Kato, K, Hermosilla, P, Thureau, A, Ceballos-Laita, L, Coelho, H, Bernado, P, Marcelo, F, Hansen, L, Lostao, A, Corzana, F, Clausen, H, Gerken, T.A, Hurtado-Guerrero, R.
Deposit date:2019-06-20
Release date:2019-12-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
Nat.Chem.Biol., 16, 2020
6S22
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BU of 6s22 by Molmil
Crystal structure of the TgGalNAc-T3 in complex with UDP, manganese and FGF23c
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:de las Rivas, M, Daniel, E.J.P, Narimatsu, Y, Companon, I, Kato, K, Hermosilla, P, Thureau, A, Ceballos-Laita, L, Coelho, H, Bernado, P, Marcelo, F, Hansen, L, Lostao, A, Corzana, F, Clausen, H, Gerken, T.A, Hurtado-Guerrero, R.
Deposit date:2019-06-20
Release date:2019-12-25
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.
Nat.Chem.Biol., 16, 2020
4D69
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BU of 4d69 by Molmil
SOYBEAN AGGLUTININ FROM GLYCINE MAX IN COMPLEX WITH THE ANTIGEN Tn
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LECTIN, ...
Authors:Madariaga, D, Martinez-Saez, N, Somovilla, V.J, Coelho, H, Valero-Gonzalez, J, Castro-Lopez, J, Asensio, J.L, Jimenez-Barbero, J, Busto, J.H, Avenoza, A, Marcelo, F, Hurtado-Guerrero, R, Corzana, F, Peregrina, J.M.
Deposit date:2014-11-10
Release date:2014-11-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Detection of Tumor-Associated Glycopeptides by Lectins: The Peptide Context Modulates Carbohydrate Recognition.
Acs Chem.Biol., 10, 2015
6W12
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BU of 6w12 by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to the Tumor-Associated Tn Antigen
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, C-type lectin domain family 10 member A, CALCIUM ION, ...
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2020-03-03
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
6XIY
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BU of 6xiy by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to methyl 2-(acetylamino)-2-deoxy-1-thio-alpha-D-galactopyranose
Descriptor: C-type lectin domain family 10 member A, CALCIUM ION, CHLORIDE ION, ...
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2020-06-22
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
6TNP
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BU of 6tnp by Molmil
Crystal structure of the ScFv-5E5 in complex with a Tn glycopeptide
Descriptor: (2~{S})-~{N}-[2-[[(2~{S})-1-[[(2~{S},3~{R})-3-[(2~{S},3~{R},4~{R},5~{R},6~{R})-3-acetamido-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-2-yl]oxy-1-[[(2~{S})-1-[(2~{S})-2-aminocarbonylpyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]amino]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanyl-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethyl]-1-[(2~{S})-2-azanylpropanoyl]pyrrolidine-2-carboxamide, Heavy chain of our ScFv-5E5, Light chain of our ScFv-5E5
Authors:Macias-Leon, J, Corzana, F, Hurtado-Guerrero, R.
Deposit date:2019-12-09
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody.
Chem.Commun.(Camb.), 56, 2020
7QUI
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BU of 7qui by Molmil
Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue
Descriptor: (2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid, Sialic acid-binding Ig-like lectin 8
Authors:Lenza, M.P, Oyenarte, I, Atxabal, U, Nycholat, C, Franconetti, A, Quintana, J.I, Delgado, S, Unione, L, Paulson, J, Jimenez-Barbero, J, Ereno-Orbea, J.
Deposit date:2022-01-18
Release date:2023-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.352 Å)
Cite:Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody.
Jacs Au, 3, 2023
7QU6
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BU of 7qu6 by Molmil
Crystal structure of the N-terminal domain of Siglec-8
Descriptor: Sialic acid-binding Ig-like lectin 8
Authors:Lenza, M.P, Atxabal, U, Nycholat, C.M, Oyenarte, I, Paulson, J.C, Franconetti, A, Quintana, J.I, Unione, L, Delgado, S, Jimenez-Barbero, J, Ereno-Orbea, J.
Deposit date:2022-01-17
Release date:2023-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody.
Jacs Au, 3, 2023
7QUH
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BU of 7quh by Molmil
Siglec-8 in complex with therapeutic Fab AK002.
Descriptor: Sialic acid-binding Ig-like lectin 8, Sialic acid-binding immunoglobulin-type lectin
Authors:Lenza, M.P, Oyenarte, I, Jimenez Barbero, J, Ereno Orbea, J.
Deposit date:2022-01-18
Release date:2023-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.867 Å)
Cite:Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody.
Jacs Au, 3, 2023
7BE3
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BU of 7be3 by Molmil
Human Galectin-3 in complex with LacdiNAc
Descriptor: 2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
Authors:Trovao, F, Carvalho, A.L.
Deposit date:2020-12-22
Release date:2021-04-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins.
Chemistry, 27, 2021
6PY1
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BU of 6py1 by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, ACETATE ION, C-type lectin domain family 10 member A, ...
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2019-07-28
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
6PUV
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BU of 6puv by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin
Descriptor: C-type lectin domain family 10 member A, CALCIUM ION
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2019-07-18
Release date:2020-07-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
7ZOR
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BU of 7zor by Molmil
Crystal structure of anti-Siglec-15 Fab
Descriptor: Anti-siglec15 FAB HC, Anti-siglec15 FAB LC
Authors:Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J.
Deposit date:2022-04-26
Release date:2023-06-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.933 Å)
Cite:Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.
Nat Commun, 14, 2023
7ZOZ
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BU of 7zoz by Molmil
Crystal structure of Siglec-15 in complex with Fab
Descriptor: Anti-Siglec 15 Fab HC, Anti-Siglec 15 Fab LC, Sialic acid-binding Ig-like lectin 15
Authors:Lenza, M.P, Oyenarte, I, Jimenez-Barbero, J, Ereno-Orbea, J.
Deposit date:2022-04-26
Release date:2023-06-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b.
Nat Commun, 14, 2023

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