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1A9U
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BU of 1a9u by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580
Descriptor: 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, MAP KINASE P38
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-04-10
Release date:1999-04-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
6OT6
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BU of 6ot6 by Molmil
Rat ERK2 D319N
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION
Authors:Taylor, C.A, Goldsmith, E.J, Cobb, M.H.
Deposit date:2019-05-02
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
1BMK
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BU of 1bmk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655
Descriptor: 4-(FLUOROPHENYL)-1-CYCLOPROPYLMETHYL-5-(2-AMINO-4-PYRIMIDINYL)IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL6
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BU of 1bl6 by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995
Descriptor: 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-11
Release date:1999-07-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1BL7
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THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025
Descriptor: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, PROTEIN (MAP KINASE P38)
Authors:Wang, Z, Canagarajah, B.J, Boehm, J.C, Kassis, S, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-23
Release date:1999-07-26
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
4ERK
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BU of 4erk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE
Descriptor: EXTRACELLULAR REGULATED KINASE 2, OLOMOUCINE, SULFATE ION
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-09
Release date:1999-07-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1U5Q
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BU of 1u5q by Molmil
Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
Descriptor: CALCIUM ION, serine/threonine protein kinase TAO2
Authors:Zhou, T, Raman, M, Gao, Y, Earnest, S, Chen, Z, Machius, M, Cobb, M.H, Goldsmith, E.J.
Deposit date:2004-07-28
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the TAO2 Kinase Domain; Activation and Specificity of a Ste20p MAP3K.
STRUCTURE, 12, 2004
1U5R
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BU of 1u5r by Molmil
Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ...
Authors:Zhou, T, Raman, M, Gao, Y, Earnest, S, Chen, Z, Machius, M, Cobb, M.H, Goldsmith, E.J.
Deposit date:2004-07-28
Release date:2004-10-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the TAO2 Kinase Domain; Activation and Specificity of a Ste20p MAP3K.
Structure, 12, 2004
5D9H
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BU of 5d9h by Molmil
Crystal structure of SPAK (STK39) dimer in the basal activity state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, STE20/SPS1-related proline-alanine-rich protein kinase, ...
Authors:Taylor, C.A, Juang, Y.C, Goldsmith, E.J, Cobb, M.H.
Deposit date:2015-08-18
Release date:2015-09-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Biochemistry, 54, 2015
4Q2A
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BU of 4q2a by Molmil
WNK1: A chloride sensor via autophosphorylation
Descriptor: BROMIDE ION, Serine/threonine-protein kinase WNK1
Authors:Piala, A, Moon, T, Akella, R, He, H, Cobb, M.H, Goldsmith, E.
Deposit date:2014-04-07
Release date:2014-05-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation.
Sci.Signal., 7, 2014
6OTS
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BU of 6ots by Molmil
Rat ERK2 E320K
Descriptor: Mitogen-activated protein kinase 1
Authors:Taylor, C.A, Cormier, K.W, Juang, Y.-C, Goldsmith, E.J, Cobb, M.H.
Deposit date:2019-05-03
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
1LEW
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BU of 1lew by Molmil
CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS NUCLEAR SUBSTRATE MEF2A
Descriptor: Mitogen-activated protein kinase 14, Myocyte-specific enhancer factor 2A
Authors:Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J.
Deposit date:2002-04-10
Release date:2002-07-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Mol.Cell, 9, 2002
1LEZ
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BU of 1lez by Molmil
CRYSTAL STRUCTURE OF MAP KINASE P38 COMPLEXED TO THE DOCKING SITE ON ITS ACTIVATOR MKK3B
Descriptor: MAP kinase kinase 3b, MITOGEN-ACTIVATED PROTEIN KINASE 14
Authors:Chang, C.-I, Xu, B.-E, Akella, R, Cobb, M.H, Goldsmith, E.J.
Deposit date:2002-04-10
Release date:2002-07-10
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Mol.Cell, 9, 2002
3DAK
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BU of 3dak by Molmil
Crystal Structure of Domain-Swapped OSR1 kinase domain
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase OSR1
Authors:Lee, S, Cobb, M.H, Goldsmith, E.J.
Deposit date:2008-05-29
Release date:2009-02-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of domain-swapped STE20 OSR1 kinase domain.
Protein Sci., 18, 2008
3ENM
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BU of 3enm by Molmil
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
Descriptor: 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 6, GLYCEROL, ...
Authors:Min, X, Akella, R, He, H, Humphreys, J.M, Tsutakawa, S, Lee, S.-J, Tainer, J.A, Cobb, M.H, Goldsmith, E.J.
Deposit date:2008-09-25
Release date:2009-03-03
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structure of the MAP2K MEK6 reveals an autoinhibitory dimer
Structure, 17, 2009
3ERK
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BU of 3erk by Molmil
THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025
Descriptor: 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, EXTRACELLULAR REGULATED KINASE 2
Authors:Wang, Z, Canagarajah, B, Boehm, J.C, Cobb, M.H, Young, P.R, Abdel-Meguid, S, Adams, J.L, Goldsmith, E.J.
Deposit date:1998-07-09
Release date:1999-07-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of inhibitor selectivity in MAP kinases.
Structure, 6, 1998
1GOL
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BU of 1gol by Molmil
COORDINATES OF RAT MAP KINASE ERK2 WITH AN ARGININE MUTATION AT POSITION 52
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, EXTRACELLULAR REGULATED KINASE 2, MAGNESIUM ION
Authors:Harkins, P.C, Zhang, F, Goldsmith, E.J.
Deposit date:1996-01-23
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate.
Biochemistry, 35, 1996
6CN9
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BU of 6cn9 by Molmil
Crystal structure of the Kinase domain of WNK1
Descriptor: GLYCEROL, SULFATE ION, Serine/threonine-protein kinase WNK1
Authors:Akella, R, Goldsmith, E.J.
Deposit date:2018-03-07
Release date:2019-03-27
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Structure, 12, 2004
4PWN
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BU of 4pwn by Molmil
Crystal structure of Active WNK1 kinase
Descriptor: PHOSPHATE ION, Serine/threonine-protein kinase WNK1
Authors:Piala, A, Moon, T, Akella, T, He, H, Cobbm, M.H, Goldsmith, E.
Deposit date:2014-03-20
Release date:2014-05-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation.
Sci.Signal., 7, 2014
5UOJ
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BU of 5uoj by Molmil
THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION
Descriptor: Mitogen-activated protein kinase 14
Authors:CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J.
Deposit date:2017-01-31
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.
Proc. Natl. Acad. Sci. U.S.A., 94, 1997
5UMO
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BU of 5umo by Molmil
STRUCTURE OF EXTRACELLULAR SIGNAL-REGULATED KINASE
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION
Authors:CHLEBOWICZ, J, ZHANG, F, GOLDSMITH, E.J.
Deposit date:2017-01-27
Release date:2017-03-01
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Atomic structure of the MAP kinase ERK2 at 2.3 A resolution.
Nature, 367, 1994
5DBX
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BU of 5dbx by Molmil
Crystal structure of murine SPAK(T243D) in complex with AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, STE20/SPS1-related proline-alanine-rich protein kinase
Authors:Juang, Y.-C.
Deposit date:2015-08-22
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Biochemistry, 54, 2015
2ERK
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BU of 2erk by Molmil
PHOSPHORYLATED MAP KINASE ERK2
Descriptor: EXTRACELLULAR SIGNAL-REGULATED KINASE 2
Authors:Canagarajah, B.J, Goldsmith, E.J.
Deposit date:1997-06-26
Release date:1998-07-01
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Activation mechanism of the MAP kinase ERK2 by dual phosphorylation.
Cell(Cambridge,Mass.), 90, 1997
2GCD
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BU of 2gcd by Molmil
TAO2 kinase domain-staurosporine structure
Descriptor: STAUROSPORINE, Serine/threonine-protein kinase TAO2
Authors:Zhou, T, Sun, L, Gao, Y, Earnest, S, Cobb, M.H, Goldsmith, E.J.
Deposit date:2006-03-14
Release date:2006-09-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.
Acta Biochim.Biophys.Sinica, 38, 2006

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