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6FUW
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BU of 6fuw by Molmil
Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution
Descriptor: Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ...
Authors:Clerici, M, Faini, M, Jinek, M.
Deposit date:2018-02-28
Release date:2018-03-21
Last modified:2023-02-22
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
6F9N
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BU of 6f9n by Molmil
CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX
Descriptor: Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33
Authors:Clerici, M, Jinek, M.
Deposit date:2017-12-14
Release date:2018-01-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
Elife, 6, 2017
4CEM
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BU of 4cem by Molmil
Crystal structure of the first MIF4G domain of human nonsense mediated decay factor UPF2
Descriptor: REGULATOR OF NONSENSE TRANSCRIPTS 2
Authors:Clerici, M, Deniaud, A, Boehm, V, Gehring, N.H, Schaffitzel, C, Cusack, S.
Deposit date:2013-11-11
Release date:2013-12-11
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Functional Analysis of the Three Mif4G Domains of Nonsense-Mediated Decay Factor Upf2.
Nucleic Acids Res., 42, 2014
4CEK
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BU of 4cek by Molmil
Crystal structure of the second MIF4G domain of human nonsense mediated decay factor UPF2
Descriptor: REGULATOR OF NONSENSE TRANSCRIPTS 2
Authors:Clerici, M, Deniaud, A, Boehm, V, Gehring, N.H, Schaffitzel, C, Cusack, S.
Deposit date:2013-11-11
Release date:2013-12-11
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and Functional Analysis of the Three Mif4G Domains of Nonsense-Mediated Decay Factor Upf2.
Nucleic Acids Res., 42, 2014
2WJY
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BU of 2wjy by Molmil
Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2 Orthorhombic form
Descriptor: REGULATOR OF NONSENSE TRANSCRIPTS 1, SULFATE ION, ZINC ION
Authors:Clerici, M, Mourao, A, Gutsche, I, Gehring, N.H, Hentze, M.W, Kulozik, A, Kadlec, J, Sattler, M, Cusack, S.
Deposit date:2009-06-01
Release date:2009-07-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2.
Embo J., 28, 2009
2WJV
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BU of 2wjv by Molmil
Crystal structure of the complex between human nonsense mediated decay factors UPF1 and UPF2
Descriptor: REGULATOR OF NONSENSE TRANSCRIPTS 1, REGULATOR OF NONSENSE TRANSCRIPTS 2, SULFATE ION, ...
Authors:Clerici, M, Mourao, A, Gutsche, I, Gehring, N.H, Hentze, M.W, Kulozik, A, Kadlec, J, Sattler, M, Cusack, S.
Deposit date:2009-06-01
Release date:2009-07-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Unusual Bipartite Mode of Interaction between the Nonsense-Mediated Decay Factors, Upf1 and Upf2.
Embo J., 28, 2009
5L8H
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BU of 5l8h by Molmil
Structure of USP46-UbVME
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, ZINC ION
Authors:Clerici, M, Sixma, T, Dharadhar, S.
Deposit date:2016-06-07
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
J.Struct.Biol., 196, 2016
7ZYH
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BU of 7zyh by Molmil
Crystal structure of human CPSF30 in complex with hFip1
Descriptor: Cleavage and polyadenylation specificity factor subunit 4, Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1, ZINC ION
Authors:Muckenfuss, L.M, Jinek, M, Migenda Herranz, A.C, Clerici, M.
Deposit date:2022-05-24
Release date:2022-09-14
Last modified:2022-09-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
Elife, 11, 2022
2Y6E
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BU of 2y6e by Molmil
Structure of the D1D2 domain of USP4, the conserved catalytic domain
Descriptor: SULFATE ION, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4, ZINC ION
Authors:Luna-Vargas, M.P.A, Faesen, A.C, van Dijk, W.J, Rape, M, Fish, A, Sixma, T.K.
Deposit date:2011-01-20
Release date:2011-04-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Dusp-Ubl Domain of Usp4 Enhances its Catalytic Efficiency by Promoting Ubiquitin Exchange.
Nat.Commun., 5, 2014
7ZY4
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BU of 7zy4 by Molmil
Crystal structure of human CstF77 in complex with hFip1
Descriptor: Cleavage stimulation factor subunit 3, GLYCEROL, hFip1
Authors:Muckenfuss, L.M, Jinek, M.
Deposit date:2022-05-23
Release date:2022-09-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
Elife, 11, 2022
6AQR
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BU of 6aqr by Molmil
SAGA DUB module Ubp8(C146A)/Sgf11/Sus1/Sgf73 bound to monoubiquitin
Descriptor: Polyubiquitin-C, SAGA-associated factor 11, SAGA-associated factor 73, ...
Authors:Morrow, M.E, Morgan, M.T, Wolberger, C.
Deposit date:2017-08-21
Release date:2018-07-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.
EMBO Rep., 19, 2018
2XR6
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BU of 2xr6 by Molmil
Crystal structure of the complex of the carbohydrate recognition domain of human DC-SIGN with pseudo trimannoside mimic.
Descriptor: 2-AZIDOETHANOL, CALCIUM ION, CD209 ANTIGEN, ...
Authors:Thepaut, M, Suitkeviciute, I, Sattin, S, Reina, J, Bernardi, A, Fieschi, F.
Deposit date:2010-09-10
Release date:2011-10-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Unique Dc-Sign Clustering Activity of a Small Glycomimetic: A Lesson for Ligand Design.
Acs Chem.Biol., 9, 2014
5L8W
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BU of 5l8w by Molmil
Structure of USP12-UB-PRG/UAF1
Descriptor: GLYCEROL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 12, ...
Authors:Dharadhar, S, Sixma, T.
Deposit date:2016-06-08
Release date:2016-09-28
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
J.Struct.Biol., 196, 2016
5L8E
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BU of 5l8e by Molmil
Structure of UAF1
Descriptor: GLYCEROL, Unknown, WD repeat-containing protein 48
Authors:Dharadhar, S, Sixma, T.
Deposit date:2016-06-07
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
J.Struct.Biol., 196, 2016

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