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4LSJ
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CRYSTAL STRUCTURE OF THE GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN BOUND TO A DIBENZOXAPINE SULFONAMIDE
分子名称:Glucocorticoid receptor, D30 peptide, N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide
著者Carson, M., Luz, J.G., Clawson, D., Coghlan, M.
登録日2013-07-22
公開日2014-01-29
最終更新日2014-03-12
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.
J.Med.Chem., 57, 2014
5UY8
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CRYSTAL STRUCTURE OF AICARFT BOUND TO AN ANTIFOLATE
分子名称:Bifunctional purine biosynthesis protein PURH, 5-[(5S)-5-ethyl-5-methyl-6-oxo-1,4,5,6-tetrahydropyridin-3-yl]-N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)thiophene-2-sulfonamide, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, ...
著者Wang, J., Wang, Y., Fales, K.R., Atwell, S., Clawson, D.
登録日2017-02-23
公開日2018-01-10
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J. Med. Chem., 60, 2017
5UZ0
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CRYSTAL STRUCTURE OF AICARFT BOUND TO AN ANTIFOLATE
分子名称:Bifunctional purine biosynthesis protein PURH, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, MAGNESIUM ION, ...
著者Atwell, S., Wang, Y., Fales, K.R., Clawson, D., Wang, J.
登録日2017-02-24
公開日2018-01-10
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
J. Med. Chem., 60, 2017
1QP1
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KAPPA VARIABLE LIGHT CHAIN
分子名称:BENCE-JONES KAPPA I ANTIBODY BRE (LIGHT CHAIN)
著者Steinrauf, L.K.
登録日1999-05-30
公開日1999-06-17
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Molecular structure of the amyloid-forming protein kappa I Bre.
J.Biochem.(Tokyo), 125, 1999