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5NQA
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CRYSTAL STRUCTURE OF GALNAC-T4 IN COMPLEX WITH THE MONOGLYCOPEPTIDE 3
Descriptor:Polypeptide N-acetylgalactosaminyltransferase 4, Monoglycopeptide 3, 1,2-ETHANEDIOL, ...
Authors:de las Rivas, M., Lira-Navarrete, E., Daniel, E.J.P., Companon, I., Coelho, H., Diniz, A., Jimenez-Barbero, J., Peregrina, J.M., Clausen, H., Corzana, F., Marcelo, F., Jimenez-Oses, G., Gerken, T.A., Hurtado-Guerrero, R.
Deposit date:2017-04-19
Release date:2017-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.
Nat Commun, 8, 2017
6EGS
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CRYSTAL STRUCTURE OF THE GALNAC-T2 F104S MUTANT IN COMPLEX WITH UDP-GALNAC
Descriptor:Polypeptide N-acetylgalactosaminyltransferase 2, MANGANESE (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE
Authors:de las Rivas, M., Coelho, H., Diniz, A., Lira-Navarrete, E., Jimenez-Barbero, J., Schjoldager, K.T., Bennett, E.P., Vakhrushev, S.Y., Clausen, H., Corzana, F., Marcelo, F., Hurtado-Guerrero, R.
Deposit date:2017-09-12
Release date:2018-04-11
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts.
Chemistry, 24, 2018
6H0B
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CRYSTAL STRUCTURE OF THE HUMAN GALNAC-T4 IN COMPLEX WITH UDP, MANGANESE AND THE DIGLYCOPEPTIDE 6.
Descriptor:Polypeptide N-acetylgalactosaminyltransferase 4, ALA-THR-GLY-ALA-GLY-ALA-GLY-ALA-GLY-THR-THR-PRO-GLY-PRO-GLY, 1,2-ETHANEDIOL, ...
Authors:de las Rivas, M., Daniel, E.J.P., Coelho, H., Lira-Navarrete, E., Raich, L., Companon, I., Diniz, A., Lagartera, L., Jimenez-Barbero, J., Clausen, H., Rovira, C., Marcelo, F., Corzana, F., Gerken, T.A., Hurtado-Guerrero, R.
Deposit date:2018-07-08
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.
ACS Cent Sci, 4, 2018
2IXA
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A-ZYME, N-ACETYLGALACTOSAMINIDASE
Descriptor:ALPHA-N-ACETYLGALACTOSAMINIDASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4R)-2-METHYLPENTANE-2,4-DIOL, ...
Authors:Sulzenbacher, G., Liu, Q.P., Bourne, Y., Henrissat, B., Clausen, H.
Deposit date:2006-07-07
Release date:2007-04-10
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bacterial Glycosidases for the Production of Universal Red Blood Cells.
Nat.Biotechnol., 25, 2007
2IXB
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CRYSTAL STRUCTURE OF N-ACETYLGALACTOSAMINIDASE IN COMPLEX WITH GALNAC
Descriptor:ALPHA-N-ACETYLGALACTOSAMINIDASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, ...
Authors:Sulzenbacher, G., Liu, Q.P., Bourne, Y., Henrissat, B., Clausen, H.
Deposit date:2006-07-07
Release date:2007-04-10
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Bacterial Glycosidases for the Production of Universal Red Blood Cells.
Nat.Biotechnol., 25, 2007
2J0A
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE
Descriptor:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION
Authors:Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2J0B
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE
Descriptor:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION, ...
Authors:Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
4D0T
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GALNAC-T2 CRYSTAL SOAKED WITH UDP-GALNAC, EA2 PEPTIDE AND MANGANESE
Descriptor:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, PEPTIDE, MANGANESE (II) ION, ...
Authors:Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R.
Deposit date:2014-04-30
Release date:2014-05-28
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.
Angew.Chem.Int.Ed.Engl., 53, 2014
4D0Z
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GALNAC-T2 CRYSTAL SOAKED WITH UDP-5SGALNAC, MEA2 AND MANGANESE (HIGHER RESOLUTION DATASET)
Descriptor:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, PEPTIDE, MANGANESE (II) ION, ...
Authors:Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R.
Deposit date:2014-04-30
Release date:2014-05-28
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
Angew.Chem.Int.Ed.Engl., 53, 2014
4D11
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GALNAC-T2 CRYSTAL SOAKED WITH UDP-5SGALNAC, MEA2 PEPTIDE AND MANGANESE (LOWER RESOLUTION DATASET)
Descriptor:POLYPEPTIDE GALNAC-TRANSFERASE T2, PEPTIDE, MANGANESE (II) ION, ...
Authors:Lira-Navarrete, E., Iglesias-Fernandez, J., Zandberg, W.F., Companon, I., Kong, Y., Corzana, F., Pinto, B.M., Clausen, H., Peregrina, J.M., Vocadlo, D., Rovira, C., Hurtado-Guerrero, R.
Deposit date:2014-05-01
Release date:2014-05-28
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.
Angew.Chem.Int.Ed.Engl., 53, 2014
5AJN
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CRYSTAL STRUCTURE OF THE INACTIVE FORM OF GALNAC-T2 IN COMPLEX WITH THE GLYCOPEPTIDE MUC5AC-CYS13
Descriptor:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, MUCIN, SULFATE ION, ...
Authors:Lira-Navarrete, E., delasRivas, M., Companon, I., Pallares, M.C., Kong, Y., Iglesias-Fernandez, J., Bernardes, G.J.L., Peregrina, J.M., Rovira, C., Bernado, P., Bruscolini, P., Clausen, H., Lostao, A., Corzana, F., Hurtado-Guerrero, R.
Deposit date:2015-02-26
Release date:2015-03-11
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Dynamic Interplay between Catalytic and Lectin Domains of Galnac-Transferases Modulates Protein O-Glycosylation.
Nat.Commun., 6, 2015
5AJO
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CRYSTAL STRUCTURE OF THE INACTIVE FORM OF GALNAC-T2 IN COMPLEX WITH THE GLYCOPEPTIDE MUC5AC-3,13
Descriptor:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, MUCIN, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, ...
Authors:Lira-Navarrete, E., delasRivas, M., Companon, I., Pallares, M.C., Kong, Y., Iglesias-Fernandez, J., Bernardes, G.J.L., Peregrina, J.M., Rovira, C., Bernado, P., Bruscolini, P., Clausen, H., Lostao, A., Corzana, F., Hurtado-Guerrero, R.
Deposit date:2015-02-26
Release date:2015-03-11
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Dynamic Interplay between Catalytic and Lectin Domains of Galnac-Transferases Modulates Protein O-Glycosylation.
Nat.Commun., 6, 2015
5AJP
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CRYSTAL STRUCTURE OF THE ACTIVE FORM OF GALNAC-T2 IN COMPLEX WITH UDP AND THE GLYCOPEPTIDE MUC5AC-13
Descriptor:POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2, MUCIN, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lira-Navarrete, E., delasRivas, M., Companon, I., Pallares, M.C., Kong, Y., Iglesias-Fernandez, J., Bernardes, G.J.L., Peregrina, J.M., Rovira, C., Bernado, P., Bruscolini, P., Clausen, H., Lostao, A., Corzana, F., Hurtado-Guerrero, R.
Deposit date:2015-02-26
Release date:2015-03-11
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Dynamic Interplay between Catalytic and Lectin Domains of Galnac-Transferases Modulates Protein O-Glycosylation.
Nat.Commun., 6, 2015
4ZPL
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CRYSTAL STRUCTURE OF PROTOCADHERIN BETA 1 EC1-3
Descriptor:Protein Pcdhb1, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Goodman, K.M., Bahna, F., Shapiro, L.
Deposit date:2015-05-08
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015
4ZPM
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CRYSTAL STRUCTURE OF PROTOCADHERIN ALPHA C2 EC1-3
Descriptor:Protein Pcdhac2, ALPHA-D-MANNOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Goodman, K.M., Mannepalli, S., Shapiro, L.
Deposit date:2015-05-08
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015
4ZPN
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CRYSTAL STRUCTURE OF PROTOCADHERIN GAMMA C5 EC1-3 WITH EXTENDED N-TERMINUS
Descriptor:MCG133388, isoform CRA_f, CALCIUM ION, ...
Authors:Goodman, K.M., Wolcott, H.N., Bahna, F., Shapiro, L.
Deposit date:2015-05-08
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015
4ZPO
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CRYSTAL STRUCTURE OF PROTOCADHERIN GAMMA C5 EC1-3
Descriptor:MCG133388, isoform CRA_f, CALCIUM ION, ...
Authors:Wolcott, H.N., Goodman, K.M., Bahna, F., Mannepalli, S., Rubinstein, R., Honig, B., Shapiro, L.
Deposit date:2015-05-08
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015
4ZPP
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CRYSTAL STRUCTURE OF PROTOCADHERIN GAMMA C5 EC1-3
Descriptor:MCG133388, isoform CRA_f, CALCIUM ION, ...
Authors:Wolcott, H.N., Goodman, K.M., Bahna, F., Mannepalli, S., Shapiro, L.
Deposit date:2015-05-08
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (3.002 Å)
Cite:Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015
4ZPQ
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CRYSTAL STRUCTURE OF PROTOCADHERIN GAMMA C5 EC1-3
Descriptor:MCG133388, isoform CRA_f, CALCIUM ION, ...
Authors:Wolcott, H.N., Goodman, K.M., Bahna, F., Mannepalli, S., Shapiro, L.
Deposit date:2015-05-08
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (3.099 Å)
Cite:Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015
4ZPS
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CRYSTAL STRUCTURE OF PROTOCADHERIN GAMMA A8 EC1-3
Descriptor:MCG133388, isoform CRA_m, ALPHA-D-MANNOSE, ...
Authors:Goodman, K.M., Mannepalli, S., Shapiro, L.
Deposit date:2015-05-08
Release date:2015-10-28
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions.
Cell, 163, 2015