Author results

4L0N
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CRYSTAL STRUCTURE OF STK3 (MST2) SARAH DOMAIN
Descriptor:Serine/threonine-protein kinase 3
Authors:Chaikuad, A., Krojer, T., Newman, J.A., Dixon-Clarke, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-05-31
Release date:2013-06-19
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of STK3 (MST2) SARAH domain
To be Published
4XWX
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CRYSTAL STRUCTURE OF THE PTB DOMAIN OF SHC
Descriptor:SHC-transforming protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Chaikuad, A., Tallant, C., Krojer, T., Dixon-Clarke, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2015-01-29
Release date:2015-02-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structure of the PTB domain of SHC
To Be Published
1JG1
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CRYSTAL STRUCTURE OF L-ISOASPARTYL (D-ASPARTYL) O-METHYLTRANSFERASE WITH S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:protein-L-isoaspartate O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Griffith, S.C., Sawaya, M.R., Boutz, D., Thapar, N., Katz, J., Clarke, S., Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1JG2
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CRYSTAL STRUCTURE OF L-ISOASPARTYL (D-ASPARTYL) O-METHYLTRANSFERASE WITH ADENOSINE
Descriptor:protein-L-isoaspartate O-methyltransferase, SODIUM ION, ADENOSINE
Authors:Griffith, S.C., Sawaya, M.R., Boutz, D., Thapar, N., Katz, J., Clarke, S., Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1JG3
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CRYSTAL STRUCTURE OF L-ISOASPARTYL (D-ASPARTYL) O-METHYLTRANSFERASE WITH ADENOSINE & VYP(ISP)HA SUBSTRATE
Descriptor:protein-L-isoaspartate O-methyltransferase, VYP(L-iso-ASP)HA, CHLORIDE ION, ...
Authors:Griffith, S.C., Sawaya, M.R., Boutz, D., Thapar, N., Katz, J., Clarke, S., Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1JG4
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CRYSTAL STRUCTURE OF L-ISOASPARTYL (D-ASPARTYL) O-METHYLTRANSFERASE WITH S-ADENOSYLMETHIONINE
Descriptor:protein-L-isoaspartate O-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Griffith, S.C., Sawaya, M.R., Boutz, D., Thapar, N., Katz, J., Clarke, S., Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1KR5
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CRYSTAL STRUCTURE OF HUMAN L-ISOASPARTYL METHYLTRANSFERASE
Descriptor:Protein-L-isoaspartate O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Ryttersgaard, C., Griffith, S.C., Sawaya, M.R., MacLaren, D.C., Clarke, S., Yeates, T.O.
Deposit date:2002-01-08
Release date:2002-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human L-isoaspartyl methyltransferase.
J.Biol.Chem., 277, 2002
4URJ
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CRYSTAL STRUCTURE OF HUMAN BJ-TSA-9
Descriptor:PROTEIN FAM83A, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Sanvitale, C., Wang, D., Krojer, T., Kopec, J., Chaikuad, A., Dixon Clarke, S., Berridge, G., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Bullock, A.
Deposit date:2014-06-30
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Bj-Tsa-9
To be Published
1L5X
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THE 2.0-ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF A SURVIVAL PROTEIN E (SURE) HOMOLOG FROM PYROBACULUM AEROPHILUM
Descriptor:Survival protein E, GLYCEROL, ACETIC ACID
Authors:Mura, C., Katz, J.E., Clarke, S.G., Eisenberg, D.
Deposit date:2002-03-08
Release date:2003-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and Function of an Archaeal Homolog of Survival Protein E (SurE-alpha): An Acid Phosphatase with Purine Nucleotide Specificity
J.Mol.Biol., 326, 2003
1ILV
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CRYSTAL STRUCTURE ANALYSIS OF THE TM107
Descriptor:STATIONARY-PHASE SURVIVAL PROTEIN SURE HOMOLOG
Authors:Zhang, R., Joachimiak, A., Edwards, A., Savchenko, A., Beasley, S., Evdokimova, E., Midwest Center for Structural Genomics (MCSG)
Deposit date:2001-05-08
Release date:2001-10-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.
Structure, 9, 2001
4TXC
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CRYSTAL STRUCTURE OF DAPK1 KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:Death-associated protein kinase 1, 4-(3-{3-[(R)-{[2-(dimethylamino)ethyl]amino}(hydroxy)methyl]phenyl}imidazo[1,2-b]pyridazin-6-yl)-2-methoxyphenol, 1,2-ETHANEDIOL
Authors:Sorrell, F.J., Krojer, T., Wilbek, T.S., Skovgaard, T., Berthelsen, J., Dixon-Clarke, S., Chalk, R., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Stromgaard, K., Knapp, S.
Deposit date:2014-07-03
Release date:2014-07-23
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.951 Å)
Cite:Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.
Chembiochem, 16, 2015
5A7Q
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CRYSTAL STRUCTURE OF HUMAN JMJD2A IN COMPLEX WITH COMPOUND 30
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4A, MANGANESE (II) ION, 2-(5-azanyl-2-oxidanyl-phenyl)pyridine-4-carboxylic acid, ...
Authors:Velupillai, S., Krojer, T., Gileadi, C., Johansson, C., Korczynska, M., Le, D.D., Younger, N., Gregori-Puigjane, E., Tumber, A., Iwasa, E., Pollock, S.B., Ortiz Torres, I., Kopec, J., Dixon-Clarke, S., MacKenzie, A., Nowak, R., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Shoichet, B.K., Fujimori, D.G., Oppermann, U.
Deposit date:2015-07-09
Release date:2016-01-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Docking and Linking of Fragments to Discover Jumonji Histone Demethylase Inhibitors.
J.Med.Chem., 59, 2016
4CKR
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CRYSTAL STRUCTURE OF THE HUMAN DDR1 KINASE DOMAIN IN COMPLEX WITH DDR1-IN-1
Descriptor:EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1, 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL
Authors:Canning, P., Elkins, J.M., Goubin, S., Mahajan, P., Krojer, T., Newman, J.A., Dixon-Clarke, S., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-01-07
Release date:2014-01-15
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of a Potent and Selective Ddr1 Receptor Tyrosine Kinase Inhibitor.
Acs Chem.Biol., 8, 2013
5FII
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STRUCTURE OF A HUMAN ASPARTATE KINASE, CHORISMATE MUTASE AND TYRA DOMAIN.
Descriptor:PHENYLALANINE-4-HYDROXYLASE, PHENYLALANINE
Authors:Patel, D., Kopec, J., Shrestha, L., Fitzpatrick, F., Pinkas, D., Chaikuad, A., Dixon-Clarke, S., McCorvie, T.J., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2015-09-25
Release date:2016-03-30
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Ligand-Dependent Dimerization of Phenylalanine Hydroxylase Regulatory Domain.
Sci.Rep., 6, 2016
4O29
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PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE FROM PYROBACULUM AEROPHILUM IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE
Descriptor:Protein-L-isoaspartate O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Sawaya, M.R., Yeates, T.O., Griffith, S.C.
Deposit date:2013-12-17
Release date:2014-01-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of L-isoaspartyl (D-aspartyl) Methyltransferase
Thesis, University of California, Los Angeles, 2002