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8TKP
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BU of 8tkp by Molmil
Structure of the C. elegans TMC-2 complex
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Clark, S, Jeong, H, Goehring, A, Posert, R, Gouaux, E.
Deposit date:2023-07-25
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Proc.Natl.Acad.Sci.USA, 121, 2024
4URJ
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BU of 4urj by Molmil
Crystal structure of human BJ-TSA-9
Descriptor: 1,2-ETHANEDIOL, PROTEIN FAM83A
Authors:Pinkas, D.M, Sanvitale, C, Wang, D, Krojer, T, Kopec, J, Chaikuad, A, Dixon Clarke, S, Berridge, G, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Bullock, A.
Deposit date:2014-06-30
Release date:2014-10-01
Last modified:2020-03-04
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Bj-Tsa-9
To be Published
4XWX
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BU of 4xwx by Molmil
Crystal structure of the PTB domain of SHC
Descriptor: 1,2-ETHANEDIOL, SHC-transforming protein 1, SODIUM ION
Authors:Chaikuad, A, Tallant, C, Krojer, T, Dixon-Clarke, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2015-01-29
Release date:2015-02-25
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structure of the PTB domain of SHC
To Be Published
4LMQ
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BU of 4lmq by Molmil
Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Descriptor: Stromal cell-derived factor 1, hu30D8 Fab heavy chain, hu30D8 Fab light chain
Authors:Zhong, Z, Wang, J, Li, B, Xiang, H, Ultsch, M, Coons, M, Wong, T, Chiang, N.Y, Clark, S, Clark, R, Quintana, L, Gribling, P, Suto, E, Barck, K, Corpuz, R, Yao, J, Takkar, R, Lee, W.P, Damico-Beyer, L.A, Carano, R.D, Adams, C, Kelley, R.F, Wang, W, Ferrara, N.
Deposit date:2013-07-10
Release date:2013-08-14
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.773 Å)
Cite:Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12.
Clin.Cancer Res., 19, 2013
4L0N
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BU of 4l0n by Molmil
Crystal structure of STK3 (MST2) SARAH domain
Descriptor: Serine/threonine-protein kinase 3
Authors:Chaikuad, A, Krojer, T, Newman, J.A, Dixon-Clarke, S, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2013-05-31
Release date:2013-06-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of STK3 (MST2) SARAH domain
To be Published
7USX
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BU of 7usx by Molmil
Structure of Contracted C. elegans TMC-1 complex
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jeong, H, Clark, S, Gouaux, E.
Deposit date:2022-04-26
Release date:2022-10-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
7USW
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BU of 7usw by Molmil
Structure of Expanded C. elegans TMC-1 complex
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jeong, H, Clark, S, Gouaux, E.
Deposit date:2022-04-26
Release date:2022-10-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
7USY
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BU of 7usy by Molmil
Structure of C. elegans TMC-1 complex with ARRD-6
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jeong, H, Clark, S, Gouaux, E.
Deposit date:2022-04-26
Release date:2022-10-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
7ABL
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BU of 7abl by Molmil
HBV pgRNA T=4 NCP icosahedral symmetry
Descriptor: Capsid protein
Authors:Patel, N, Clark, S, Weis, E.U, Mata, C.P, Bohon, J, Farquhar, E, Ranson, N.A, Twarock, R, Stockley, P.G.
Deposit date:2020-09-07
Release date:2021-10-27
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:In vitro functional analysis of gRNA sites regulating assembly of hepatitis B virus.
Commun Biol, 4, 2021
2AL5
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BU of 2al5 by Molmil
Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam
Descriptor: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2
Authors:Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
2AL4
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BU of 2al4 by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614.
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE, Glutamate receptor 2, ...
Authors:Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M.
Deposit date:2005-08-04
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
1JG1
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BU of 1jg1 by Molmil
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-ADENOSYL-L-HOMOCYSTEINE
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, protein-L-isoaspartate O-methyltransferase
Authors:Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1JG4
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BU of 1jg4 by Molmil
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-adenosylmethionine
Descriptor: S-ADENOSYLMETHIONINE, protein-L-isoaspartate O-methyltransferase
Authors:Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1JG3
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BU of 1jg3 by Molmil
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine & VYP(ISP)HA substrate
Descriptor: ADENOSINE, CHLORIDE ION, SODIUM ION, ...
Authors:Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1JG2
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BU of 1jg2 by Molmil
Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine
Descriptor: ADENOSINE, SODIUM ION, protein-L-isoaspartate O-methyltransferase
Authors:Griffith, S.C, Sawaya, M.R, Boutz, D, Thapar, N, Katz, J, Clarke, S, Yeates, T.O.
Deposit date:2001-06-22
Release date:2001-11-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate.
J.Mol.Biol., 313, 2001
1KR5
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BU of 1kr5 by Molmil
Crystal structure of human L-isoaspartyl methyltransferase
Descriptor: Protein-L-isoaspartate O-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Ryttersgaard, C, Griffith, S.C, Sawaya, M.R, MacLaren, D.C, Clarke, S, Yeates, T.O.
Deposit date:2002-01-08
Release date:2002-02-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human L-isoaspartyl methyltransferase.
J.Biol.Chem., 277, 2002
5E0M
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BU of 5e0m by Molmil
LC8 - Chica (468-476) Complex
Descriptor: Dynein light chain 1, cytoplasmic, Protein Chica peptide, ...
Authors:Clark, S.A, Barbar, E.B, Karplus, P.A.
Deposit date:2015-09-29
Release date:2015-12-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Anchored Flexibility Model in LC8 Motif Recognition: Insights from the Chica Complex.
Biochemistry, 55, 2016
5E0L
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BU of 5e0l by Molmil
LC8 - Chica (415-424) Complex
Descriptor: Dynein light chain 1, cytoplasmic, Protein Chica peptide, ...
Authors:Clark, S.A, Barbar, E.B, Karplus, P.A.
Deposit date:2015-09-29
Release date:2015-12-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:The Anchored Flexibility Model in LC8 Motif Recognition: Insights from the Chica Complex.
Biochemistry, 55, 2016
7KFV
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BU of 7kfv by Molmil
Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B12 Fab)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody C1A-B12 Fab, Spike glycoprotein, ...
Authors:Pan, J, Abraham, J, Clark, L, Clark, S.
Deposit date:2020-10-15
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
7KFY
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BU of 7kfy by Molmil
Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-F10 Fab)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of human antibody C1A-F10 Fab, ...
Authors:Pan, J, Abraham, J, Clark, L, Clark, S.
Deposit date:2020-10-15
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.157 Å)
Cite:Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
7KFX
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BU of 7kfx by Molmil
Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-C2 Fab)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of human antibody C1A-C2 Fab, ...
Authors:Pan, J, Abraham, J, Clark, L, Clark, S.
Deposit date:2020-10-15
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.226 Å)
Cite:Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
7KFW
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BU of 7kfw by Molmil
Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-B3 Fab)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, heavy chain of antibody C1A-B3 Fab, ...
Authors:Pan, J, Abraham, J, Clark, L, Clark, S.
Deposit date:2020-10-15
Release date:2020-12-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.792 Å)
Cite:Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.
Biorxiv, 2020
7SN0
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BU of 7sn0 by Molmil
Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Pan, J, Abraham, J, Clark, S.
Deposit date:2021-10-27
Release date:2021-12-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.
Science, 375, 2022
7SN1
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BU of 7sn1 by Molmil
Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab
Descriptor: neutralizing antibody C1C-A3 Fab heavy chain, neutralizing antibody C1C-A3 Fab light chain
Authors:Pan, J, Abraham, J, Clark, S.
Deposit date:2021-10-27
Release date:2021-12-08
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.467 Å)
Cite:Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.
Science, 375, 2022
4UW1
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BU of 4uw1 by Molmil
X-ray crystal structure of human TNKS in complex with a small molecule inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-{4-[(dimethylamino)methyl]phenyl}-5-methoxyisoquinolin-1(2H)-one, GLYCEROL, ...
Authors:Oliver, A.W, Rajasekaran, M.B, Pearl, L.H.
Deposit date:2014-08-08
Release date:2015-07-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.37 Å)
Cite:Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors
Medchemcommm, 6, 2015

 

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