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2AJW
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BU of 2ajw by Molmil
Structure of the cyclic conotoxin MII-6
Descriptor: Alpha-conotoxin MII
Authors:Clark, R.J, Fischer, H, Dempster, L, Daly, N.L, Rosengren, K.J, Nevin, S.T, Meunier, F.A, Adams, D.J, Craik, D.J.
Deposit date:2005-08-02
Release date:2005-09-06
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the {alpha}-conotoxin MII.
Proc.Natl.Acad.Sci.USA, 102, 2005
2AK0
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BU of 2ak0 by Molmil
Structure of cyclic conotoxin MII-7
Descriptor: Alpha-conotoxin MII
Authors:Clark, R.J, Fischer, H, Dempster, L, Daly, N.L, Rosengren, K.J, Nevin, S.T, Meunier, F.A, Adams, D.J, Craik, D.J.
Deposit date:2005-08-02
Release date:2005-09-06
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the {alpha}-conotoxin MII.
Proc.Natl.Acad.Sci.USA, 102, 2005
2F2I
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BU of 2f2i by Molmil
Solution structure of [P20D,V21K]-kalata B1
Descriptor: Kalata-B1
Authors:Clark, R.J, Daly, N.L, Craik, D.J.
Deposit date:2005-11-17
Release date:2006-01-31
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structural plasticity of the cyclic cystine knot framework: implications for biological activity and drug design
Biochem.J., 394, 2006
2F2J
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BU of 2f2j by Molmil
Solution structure of [W19K, P20N, V21K]-kalata B1
Descriptor: Kalata-B1
Authors:Clark, R.J, Daly, N.L, Craik, D.J.
Deposit date:2005-11-17
Release date:2006-01-31
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structural plasticity of the cyclic cystine knot framework: implications for biological activity and drug design
Biochem.J., 394, 2006
2H8S
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BU of 2h8s by Molmil
Solution structure of alpha-conotoxin Vc1.1
Descriptor: Alpha-conotoxin Vc1A
Authors:Clark, R.J, Fischer, H, Nevin, S.T, Adams, D.J, Craik, D.J.
Deposit date:2006-06-07
Release date:2006-06-27
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:The Synthesis, Structural Characterization, and Receptor Specificity of the {alpha}-Conotoxin Vc1.1.
J.Biol.Chem., 281, 2006
6OTA
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BU of 6ota by Molmil
THREE-DIMENSIONAL STRUCTURE IN SOLUTION OF THE RIBBON DISULFIDE ISOMER OF THE NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST ALPHA-CONOTOXIN TxIA
Descriptor: Alpha-conotoxin TxIA
Authors:Clark, R.J, Nicke, A.
Deposit date:2019-05-02
Release date:2020-05-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural and functional analysis of E. Coli-expressed 4/7 alpha-conotoxin analogues reveals preferential formation of ribbon isomers
To Be Published
6CGX
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BU of 6cgx by Molmil
Backbone cyclised conotoxin Vc1.1 mutant - D11A, E14A
Descriptor: Alpha-conotoxin Vc1A
Authors:Clark, R.J.
Deposit date:2018-02-21
Release date:2018-05-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by alpha-Conotoxin Vc1.1.
ACS Chem. Biol., 13, 2018
2L1Q
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BU of 2l1q by Molmil
Solution structure of human Liver Expressed Antimicrobial Peptide 2
Descriptor: Liver-expressed antimicrobial peptide 2
Authors:Clark, R.J.
Deposit date:2010-08-03
Release date:2010-09-22
Last modified:2020-01-01
Method:SOLUTION NMR
Cite:Structural and functional analysis of human liver-expressed antimicrobial peptide 2.
Chembiochem, 11, 2010
8UWF
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BU of 8uwf by Molmil
NMR structure of the funnel-web spider toxin Hc3a
Descriptor: Pi-Hexatoxin-Hc1b_1
Authors:Budusan, E, Payne, C.D, Gonzalez, T.I, Clark, R.J, Rosengren, K.J, Rash, L.D, Cristofori-Armstrong, B.
Deposit date:2023-11-06
Release date:2024-03-13
Last modified:2024-04-10
Method:SOLUTION NMR
Cite:The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation.
Biochem Pharmacol, 2024
1WN4
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BU of 1wn4 by Molmil
NMR Structure of VoNTR
Descriptor: VoNTR protein
Authors:Dutton, J.L, Renda, R.F, Waine, C, Clark, R.J, Daly, N.L, Jennings, C.V, Anderson, M.A, Craik, D.J.
Deposit date:2004-07-27
Release date:2004-09-14
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins
J.Biol.Chem., 279, 2004
1WN8
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BU of 1wn8 by Molmil
NMR Structure of OaNTR
Descriptor: Kalata B3/B6
Authors:Dutton, J.L, Renda, R.F, Waine, C, Clark, R.J, Daly, N.L, Jennings, C.V, Anderson, M.A, Craik, D.J.
Deposit date:2004-07-28
Release date:2004-09-14
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins
J.Biol.Chem., 279, 2004
2B38
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BU of 2b38 by Molmil
Solution structure of kalata B8
Descriptor: kalata B8
Authors:Daly, N.L, Clark, R.J, Plan, M.R, Craik, D.J.
Deposit date:2005-09-19
Release date:2006-01-31
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Kalata B8, a novel antiviral circular protein, exhibits conformational flexibility in the cystine knot motif
Biochem.J., 393, 2006
3LX5
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BU of 3lx5 by Molmil
Crystal structure of mGMPPNP-bound NFeoB from S. thermophilus
Descriptor: 2-amino-9-(5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-3-O-{[2-(methylamino)phenyl]carbonyl}-beta-D-erythro-pentofuranosyl-2-ulose)-1,9-dihydro-6H-purin-6-one, Ferrous iron uptake transporter protein B, GLYCEROL, ...
Authors:Ash, M.R, Guilfoyle, A, Maher, M.J, Clarke, R.J, Guss, J.M, Jormakka, M.
Deposit date:2010-02-24
Release date:2010-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Potassium-activated GTPase reaction in the G Protein-coupled ferrous iron transporter B.
J.Biol.Chem., 285, 2010
3LX8
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BU of 3lx8 by Molmil
Crystal structure of GDP-bound NFeoB from S. thermophilus
Descriptor: Ferrous iron uptake transporter protein B, GUANOSINE-5'-DIPHOSPHATE
Authors:Ash, M.R, Guilfoyle, A, Maher, M.J, Clarke, R.J, Guss, J.M, Jormakka, M.
Deposit date:2010-02-24
Release date:2010-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Potassium-activated GTPase reaction in the G Protein-coupled ferrous iron transporter B.
J.Biol.Chem., 285, 2010
2NS3
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BU of 2ns3 by Molmil
Solution structure of ribbon BuIA
Descriptor: Alpha-conotoxin BuIA
Authors:Jin, A.H, Brandstaetter, H, Nevin, S.T, Tan, C.C, Clark, R.J, Adams, D.J, Alewood, P.F, Craik, D.J, Daly, N.L.
Deposit date:2006-11-03
Release date:2007-09-25
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics
Bmc Struct.Biol., 7, 2007
6CFB
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BU of 6cfb by Molmil
Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti
Descriptor: barrettide A
Authors:Rosengren, K.J, Carstens, B.B, Clark, R.J, Goransson, U.
Deposit date:2018-02-14
Release date:2018-03-21
Last modified:2020-01-01
Method:SOLUTION NMR
Cite:Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti.
J. Nat. Prod., 78, 2015
2M2R
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BU of 2m2r by Molmil
Solution structure of MCh-2: A novel inhibitor cystine knot peptide from Momordica charantia
Descriptor: Inhibitor cystine knot peptide MCh-2
Authors:He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N.
Deposit date:2013-01-01
Release date:2013-11-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2M2Q
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BU of 2m2q by Molmil
Solution structure of MCh-1: A novel inhibitor cystine knot peptide from Momordica charantia
Descriptor: Inhibitor cystine knot peptide MCh-1
Authors:He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N.
Deposit date:2013-01-01
Release date:2013-11-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2MSQ
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BU of 2msq by Molmil
Solution study of cBru9a
Descriptor: Conotoxin cBru9a
Authors:Akcan, M, Clark, R.J, Daly, N.L, Conibear, A.C, de Faoite, A.C, Heghinian, M.C, Adams, D.J, Mari, F, Craik, D.J.
Deposit date:2014-08-05
Release date:2015-07-22
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.
Biopolymers, 104, 2015
2MSO
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BU of 2mso by Molmil
Solution study of cGm9a
Descriptor: Conotoxin Gm9.1
Authors:Akcan, M, Clark, R.J, Daly, N.L, Conibear, A.C, de Faoite, A.C, Heghinian, M.C, Adams, D.J, Mari, F, Craik, D.J.
Deposit date:2014-08-05
Release date:2015-07-22
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins.
Biopolymers, 104, 2015
7L2G
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BU of 7l2g by Molmil
NMR solution structure of Nak1 from the Necator americanus hookworm
Descriptor: ShTK domain protein
Authors:Smallwood, T.B, Rosengren, K.J, Clark, R.J.
Deposit date:2020-12-17
Release date:2021-10-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.
J.Biol.Chem., 297, 2021
1N1U
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BU of 1n1u by Molmil
NMR structure of [Ala1,15]kalata B1
Descriptor: kalata B1
Authors:Daly, N.L, Clark, R.J, Craik, D.J.
Deposit date:2002-10-20
Release date:2003-02-25
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Disulfide Folding Pathways of Cystine Knot Proteins. TYING THE KNOT WITHIN THE CIRCULAR BACKBONE OF THE CYCLOTIDES
J.Biol.Chem., 278, 2003
1ORX
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BU of 1orx by Molmil
Solution Structure of the acyclic permutant des-(24-28)-kalata B1.
Descriptor: kalata B1
Authors:Barry, D.G, Daly, N.L, Clark, R.J, Sando, L, Craik, D.J.
Deposit date:2003-03-17
Release date:2003-06-24
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity
Biochemistry, 42, 2003
1T9E
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BU of 1t9e by Molmil
NMR solution structure of a disulfide analogue of the cyclic sunflower trypsin inhibitor SFTI-1
Descriptor: Trypsin inhibitor 1
Authors:Korsinczky, M.L.J, Clark, R.J, Craik, D.J.
Deposit date:2004-05-16
Release date:2005-05-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1
Biochemistry, 44, 2005
7RC8
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BU of 7rc8 by Molmil
Solution NMR Structure of [D-Ala19]Crp4
Descriptor: Alpha-defensin 4
Authors:Conibear, A.C, Rosengren, K.J.
Deposit date:2021-07-07
Release date:2021-08-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A conserved beta-bulge glycine residue facilitates folding and increases stability of the mouse alpha-defensin cryptdin-4
Peptide Science, 114, 2022

 

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