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2B2X
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BU of 2b2x by Molmil
VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab
Descriptor: Antibody AQC2 Fab, Integrin alpha-1, MAGNESIUM ION
Authors:Clark, L.A, Boriack-Sjodin, P.A, Eldredge, J, Fitch, C, Friedman, B, Hanf, K.J, Jarpe, M, Liparoto, S.F, Li, Y, Lugovskoy, A.
Deposit date:2005-09-19
Release date:2006-04-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design
Protein Sci., 15, 2006
3EOT
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BU of 3eot by Molmil
Crystal structure of LAC031, an engineered anti-VLA1 Fab
Descriptor: FAB FRAGMENT, HEAVY CHAIN, LIGHT CHAIN
Authors:Boriack-Sjodin, P.A, Clark, L.A.
Deposit date:2008-09-29
Release date:2009-01-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An antibody loop replacement design feasibility study and a loop-swapped dimer structure.
Protein Eng.Des.Sel., 22, 2009
6Q1P
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BU of 6q1p by Molmil
Glucocerebrosidase in complex with pharmacological chaperone norIMX8
Descriptor: (2S,3S,4S,5R)-2-{[(4-methylpentyl)sulfonyl]methyl}piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vickers, C, Withers, S.G, Boraston, A.B.
Deposit date:2019-08-05
Release date:2020-08-19
Method:X-RAY DIFFRACTION (2.796 Å)
Cite:Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models.
To Be Published
6Q1N
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BU of 6q1n by Molmil
Glucocerebrosidase in complex with pharmacological chaperone IMX8
Descriptor: (2R,3S,4S,5R)-2-[2-(methylsulfanyl)ethyl]piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Vickers, C, Withers, S.G, Boraston, A.B.
Deposit date:2019-08-05
Release date:2020-08-19
Method:X-RAY DIFFRACTION (2.526 Å)
Cite:Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models.
To Be Published

217705

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