1ECM | |
1NSG | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | | Descriptor: | FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP), C49-METHYL RAPAMYCIN | | Authors: | Liang, J., Choi, J., Clardy, J. | | Deposit date: | 1997-07-01 | | Release date: | 1998-03-18 | | Last modified: | 2013-09-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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2FAP | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-(C16)-ETHOXY RAPAMYCIN COMPLEX INTERACTING WITH HUMA | | Descriptor: | FK506-BINDING PROTEIN, FRAP, C49-METHYL RAPAMYCIN | | Authors: | Liang, J., Choi, J., Clardy, J. | | Deposit date: | 1998-09-22 | | Release date: | 1999-05-18 | | Last modified: | 2013-09-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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1EI9 | | CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE 1 | | Descriptor: | PALMITOYL PROTEIN THIOESTERASE 1, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE | | Authors: | Bellizzi III, J.J., Widom, J., Kemp, C., Lu, J.Y., Das, A.K., Hofmann, S.L., Clardy, J. | | Deposit date: | 2000-02-24 | | Release date: | 2000-04-26 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
Proc.Natl.Acad.Sci.USA, 97, 2000
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1FKG | | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 | | Descriptor: | FK506 BINDING PROTEIN, 1,3-DIPHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE | | Authors: | Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J. | | Deposit date: | 1993-08-05 | | Release date: | 1994-01-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
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1FKH | | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 | | Descriptor: | FK506 BINDING PROTEIN, 1-CYCLOHEXYL-3-PHENYL-1-PROPYL-1-(3,3-DIMETHYL-1,2-DIOXYPENTYL)-2-PIPERIDINE CARBOXYLATE | | Authors: | Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J. | | Deposit date: | 1993-08-05 | | Release date: | 1994-01-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
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1FKI | | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS, AND THE X-RAY CRYSTAL STRUCTURES OF THEIR COMPLEXES WITH FKBP12 | | Descriptor: | FK506 BINDING PROTEIN, (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE | | Authors: | Holt, D.A., Luengo, J.I., Yamashita, D.S., Oh, H.-J., Konialian, A.L., Yen, H.-K., Rozamus, L.W., Brandt, M., Bossard, M.J., Levy, M.A., Eggleston, D.S., Stout, T.J., Liang, J., Schultz, L.W., Clardy, J. | | Deposit date: | 1993-08-05 | | Release date: | 1994-01-31 | | Last modified: | 2017-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | DESIGN, SYNTHESIS, AND KINETIC EVALUATION OF HIGH-AFFINITY FKBP LIGANDS AND THE X-RAY CRYSTAL-STRUCTURES OF THEIR COMPLEXES WITH FKBP12.
J.Am.Chem.Soc., 115, 1993
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1PBK | | HOMOLOGOUS DOMAIN OF HUMAN FKBP25 | | Descriptor: | FKBP25, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | Authors: | Liang, J., Hung, D.T., Schreiber, S.L., Clardy, J. | | Deposit date: | 1995-09-01 | | Release date: | 1996-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the human 25 kDa FK506 binding protein complexed with rapamycin.
J.Am.Chem.Soc., 118, 1996
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1A7X | | FKBP12-FK1012 COMPLEX | | Descriptor: | FKBP12, BENZYL-CARBAMIC ACID [8-DEETHYL-ASCOMYCIN-8-YL]ETHYL ESTER | | Authors: | Schultz, L.W., Clardy, J. | | Deposit date: | 1998-03-18 | | Release date: | 1998-06-17 | | Last modified: | 2011-11-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12.
Bioorg.Med.Chem.Lett., 8, 1998
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2B0M | | HUMAN DIHYDROOROTATE DEHYDROGENASE BOUND TO A NOVEL INHIBITOR | | Descriptor: | Dihydroorotate dehydrogenase, mitochondrial, 3-AMIDO-5-BIPHENYL-BENZOIC ACID, ... | | Authors: | Hurt, D.E., Sutton, A.E., Clardy, J. | | Deposit date: | 2005-09-14 | | Release date: | 2005-09-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase.
Bioorg.Med.Chem.Lett., 16, 2006
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1CMI | | STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE | | Descriptor: | PROTEIN INHIBITOR OF NEURONAL NITRIC OXIDE SYNTHASE, Nitric oxide synthase, brain | | Authors: | Liang, J., Guo, W., Jaffery, S., Snyder, S., Clardy, J. | | Deposit date: | 1999-05-06 | | Release date: | 2000-02-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the PIN/LC8 dimer with a bound peptide.
Nat.Struct.Biol., 6, 1999
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1EH5 | | CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE 1 COMPLEXED WITH PALMITATE | | Descriptor: | PALMITOYL PROTEIN THIOESTERASE 1, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Bellizzi III, J.J., Widom, J., Kemp, C., Lu, J.Y., Das, A.K., Hofmann, S.L., Clardy, J. | | Deposit date: | 2000-02-18 | | Release date: | 2000-04-26 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis.
Proc.Natl.Acad.Sci.USA, 97, 2000
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1FAP | | THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | | Descriptor: | FK506-BINDING PROTEIN, FRAP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | | Authors: | Choi, J., Chen, J., Schreiber, S.L., Clardy, J. | | Deposit date: | 1996-03-15 | | Release date: | 1997-07-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
Science, 273, 1996
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1KL9 | |
1KQ0 | | HUMAN METHIONINE AMINOPEPTIDASE TYPE II IN COMPLEX WITH D-METHIONINE | | Descriptor: | Methionine aminopeptidase 2, ZINC ION, D-METHIONINE, ... | | Authors: | Nonato, M.C., Widom, J., Clardy, J. | | Deposit date: | 2002-01-03 | | Release date: | 2003-12-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
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1KQ9 | | HUMAN METHIONINE AMINOPEPTIDASE TYPE II IN COMPLEX WITH L-METHIONINE | | Descriptor: | Methionine aminopeptidase 2, ZINC ION, METHIONINE, ... | | Authors: | Nonato, M.C., Widom, J., Clardy, J. | | Deposit date: | 2002-01-04 | | Release date: | 2003-12-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
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1N52 | | CAP BINDING COMPLEX | | Descriptor: | 80 kDa nuclear cap binding protein, 20 kDa nuclear cap binding protein, MAGNESIUM ION, ... | | Authors: | Calero, G., Wilson, K., Ly, T., Rios-Steiner, J., Clardy, J., Cerione, R. | | Deposit date: | 2002-11-04 | | Release date: | 2003-02-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
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1N54 | | CAP BINDING COMPLEX M7GPPPG FREE | | Descriptor: | 80 kDa nuclear cap binding protein, 20 kDa nuclear cap binding protein, GLYCEROL | | Authors: | Calero, G., Wilson, K., Ly, T., Rios-Steiner, J., Clardy, J., Cerione, R. | | Deposit date: | 2002-11-04 | | Release date: | 2003-02-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural basis of m7GpppG binding to the nuclear cap-binding protein complex.
Nat.Struct.Biol., 9, 2002
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1PHT | | PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT SH3 DOMAIN, RESIDUES 1-85 | | Descriptor: | PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT | | Authors: | Liang, J., Chen, J.K., Schreiber, S.L., Clardy, J. | | Deposit date: | 1995-08-17 | | Release date: | 1995-12-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of P13K SH3 domain at 20 angstroms resolution.
J.Mol.Biol., 257, 1996
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1TV5 | | PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE WITH A BOUND INHIBITOR | | Descriptor: | Dihydroorotate dehydrogenase homolog, mitochondrial, SULFATE ION, ... | | Authors: | Hurt, D.E., Widom, J., Clardy, J. | | Deposit date: | 2004-06-27 | | Release date: | 2005-09-06 | | Last modified: | 2012-07-18 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
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3FAP | |
4FAP | |
4NNR | | FKBP13-FK506 COMPLEX | | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP2, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | | Authors: | Schultz, L.W., Martin, P.K., Liang, J., Schreiber, S.L., Clardy, J. | | Deposit date: | 2013-11-18 | | Release date: | 2014-02-05 | | Last modified: | 2019-11-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Atomic structure of the Immunophilin FKBP13-FK506 Complex: Insights into the Composite Binding Surface for Calcineurin
J.Am.Chem.Soc., 116, 1994
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1AQ7 | |
1AUE | |
