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1S3I
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CRYSTAL STRUCTURE OF THE N TERMINAL HYDROLASE DOMAIN OF 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE
Descriptor:10-formyltetrahydrofolate dehydrogenase, BETA-MERCAPTOETHANOL
Authors:Chumanevich, A.A., Krupenko, S.A., Davies, C.
Deposit date:2004-01-13
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
J.Biol.Chem., 279, 2004
3B80
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HIV-1 PROTEASE MUTANT I54V COMPLEXED WITH GEM-DIOL-AMINE INTERMEDIATE NLLTQI
Descriptor:Protease, peptide, SODIUM ION, ...
Authors:Chumanevich, A.A., Kovalevsky, A.Y., Weber, I.T.
Deposit date:2007-10-31
Release date:2007-12-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Caught in the Act: The 1.5 A Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate.
Biochemistry, 46, 2007
3I6O
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CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE WITH MACROCYCLIC INHIBITOR GRL-0216A
Descriptor:Protease, SODIUM ION, IODIDE ION, ...
Authors:Chumanevich, A.A., Wang, Y.-F., Kovalevsky, A.Y., Weber, I.T.
Deposit date:2009-07-07
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance.
J.Med.Chem., 52, 2009
1F6L
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VARIABLE LIGHT CHAIN DIMER OF ANTI-FERRITIN ANTIBODY
Descriptor:ANTI-FERRITIN IMMUNOGLOBULIN LIGHT CHAIN
Authors:Nymalm, Y., Kravchuk, Z., Salminen, T., Chumanevich, A.A., Dubnovitsky, A.P., Kankare, J., Pentikainen, O., Lehtonen, J., Arosio, P., Martsev, S., Johnson, M.S.
Deposit date:2000-06-22
Release date:2002-10-23
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Antiferritin VL homodimer binds human spleen ferritin with high specificity
J.STRUCT.BIOL., 138, 2002
3B1T
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CRYSTAL STRUCTURE OF HUMAN PEPTIDYLARGININE DEIMINASE 4 IN COMPLEX WITH O-CL-AMIDINE
Descriptor:Protein-arginine deiminase type-4, 2-{[(2S)-1-amino-5-{[(1Z)-2-chloroethanimidoyl]amino}-1-oxopentan-2-yl]carbamoyl}benzoic acid, SULFATE ION, ...
Authors:Causey, C.P., Jones, J.E., Slack, J.L., Kamei, D., Jones Jr, L.E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A.A., Luo, Y., Hashimoto, H., Shimizu, T., Sato, M., Hofseth, L.J., Thompson, P.R.
Deposit date:2011-07-13
Release date:2011-10-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors
J.Med.Chem., 54, 2011
3B1U
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CRYSTAL STRUCTURE OF HUMAN PEPTIDYLARGININE DEIMINASE 4 IN COMPLEX WITH O-F-AMIDINE
Descriptor:Protein-arginine deiminase type-4, 2-{[(2S)-1-amino-5-{[(1Z)-2-fluoroethanimidoyl]amino}-1-oxopentan-2-yl]carbamoyl}benzoic acid, SULFATE ION, ...
Authors:Causey, C.P., Jones, J.E., Slack, J.L., Kamei, D., Jones Jr, L.E., Subramanian, V., Knuckley, B., Ebrahimi, P., Chumanevich, A.A., Luo, Y., Hashimoto, H., Shimizu, T., Sato, M., Hofseth, L.J., Thompson, P.R.
Deposit date:2011-07-13
Release date:2011-10-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Development of N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-alpha-(2-Carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors
J.Med.Chem., 54, 2011
3B7V
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HIV-1 PROTEASE COMPLEXED WITH GEM-DIOL-AMINE TETRAHEDRAL INTERMEDIATE NLLTQI
Descriptor:Protease, peptide, SODIUM ION, ...
Authors:Kovalevsky, A.Y., Chumanevich, A.A., Weber, I.T.
Deposit date:2007-10-31
Release date:2007-12-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Caught in the Act: The 1.5 A Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate.
Biochemistry, 46, 2007
3C3Y
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CRYSTAL STRUCTURE OF PFOMT, PHENYLPROPANOID AND FLAVONOID O-METHYLTRANSFERASE FROM M. CRYSTALLINUM
Descriptor:O-methyltransferase, CALCIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Kopycki, J.G., Rauh, D., Neumann, P., Stubbs, M.T.
Deposit date:2008-01-29
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.371 Å)
Cite:Biochemical and Structural Analysis of Substrate Promiscuity in Plant Mg(2+)-Dependent O-Methyltransferases
J.Mol.Biol., 378, 2008
3EDQ
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CRYSTAL STRUCTURE OF CASPASE-3 WITH INHIBITOR AC-LDESD-CHO
Descriptor:Caspase-3, AC-LDESD-CHO peptide
Authors:Fu, G.
Deposit date:2008-09-03
Release date:2008-10-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structural basis for executioner caspase recognition of P5 position in substrates.
Apoptosis, 13, 2008
3EDR
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THE CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-LDESD-CHO
Descriptor:Caspase-7, Inhibitor Ac-ldesd-cho peptide
Authors:Agniswamy, J.
Deposit date:2008-09-03
Release date:2008-10-28
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for executioner caspase recognition of P5 position in substrates.
Apoptosis, 13, 2008
3I7E
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CO-CRYSTAL STRUCTURE OF HIV-1 PROTEASE BOUND TO A MUTANT RESISTANT INHIBITOR UIC-98038
Descriptor:HIV-1 protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE
Authors:Hong, L., Tang, J., Ghosh, A.
Deposit date:2009-07-08
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Design, Synthesis, Protein-Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance.
J.Med.Chem., 52, 2009
3TWH
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SELENIUM DERIVATIZED RNA/DNA HYBRID IN COMPLEX WITH RNASE H CATALYTIC DOMAIN D132N MUTANT
Descriptor:Ribonuclease H, RNA (5'-R(*UP*CP*GP*AP*CP*A)-3'), DNA (5'-D(*AP*TP*(SDG)P*TP*CP*(SDG))-3'), ...
Authors:Rob, A., Gerlits, O., Jiang, J.S., Gan, J.H., Huang, Z.
Deposit date:2011-09-21
Release date:2012-10-03
Last modified:2014-09-24
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Novel complex MAD phasing and RNase H structural insights using selenium oligonucleotides.
Acta Crystallogr.,Sect.D, 70, 2014