Author results

4TWK
  • Download 4twk
  • View 4twk
Molmil generated image of 4twk
CRYSTAL STRUCTURE OF HUMAN TWO PORE DOMAIN POTASSIUM ION CHANNEL TREK1 (K2P2.1)
Descriptor:Potassium channel subfamily K member 2, POTASSIUM ION, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Dong, Y.Y., Tessitore, A., Goubin, S., Strain-Damerell, C., Mukhopadhyay, S., Kupinska, K., Wang, D., Chalk, R., Berridge, G., Grieben, M., Shrestha, L., Ang, J.H., Mackenzie, A., Quigley, A., Bushell, S.R., Shintre, C.A., Faust, B., Chu, A., Dong, L., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Burgess-Brown, N.A., Carpenter, E.P.
Deposit date:2014-06-30
Release date:2014-08-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)
To Be Published
5C65
  • Download 5c65
  • View 5c65
Molmil generated image of 5c65
STRUCTURE OF THE HUMAN GLUCOSE TRANSPORTER GLUT3 / SLC2A3
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Quigley, A., Chu, A., Tessitore, A., Xia, X., Mukhopadhyay, S., Wang, D., Kupinska, K., Strain-Damerell, C., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2015-06-22
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the human glucose transporter GLUT3 / SLC2A3
To Be Published
6R7X
  • Download 6r7x
  • View 6r7x
Molmil generated image of 6r7x
CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (2MM CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Baronina, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
5LEV
  • Download 5lev
  • View 5lev
Molmil generated image of 5lev
CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1) (V264G MUTANT)
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, UNKNOWN LIGAND
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2016-06-30
Release date:2016-12-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant)(CASP target)
To Be Published
5O5E
  • Download 5o5e
  • View 5o5e
Molmil generated image of 5o5e
CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1) (V264G MUTANT) IN COMPLEX WITH TUNICAMYCIN
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Tunicamycin, ...
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-01
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with tunicamycin
To Be Published
5OC9
  • Download 5oc9
  • View 5oc9
Molmil generated image of 5oc9
CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10
Descriptor:Anoctamin-10, CALCIUM ION, (2R)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., BORKOWSKA, O., CHALK, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-29
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10
TO BE PUBLISHED
5OCH
  • Download 5och
  • View 5och
Molmil generated image of 5och
THE CRYSTAL STRUCTURE OF HUMAN ABCB8 IN AN OUTWARD-FACING STATE
Descriptor:ATP-binding cassette sub-family B member 8, mitochondrial, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Faust, B., Pike, A.C.W., Shintre, C.A., Quiqley, A.M., Chu, A., Barr, A., Shrestha, L., Mukhopadhyay, S., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2017-06-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The crystal structure of human ABCB8 in an outward-facing state
To Be Published
6FM9
  • Download 6fm9
  • View 6fm9
Molmil generated image of 6fm9
CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1)
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-01-30
Release date:2018-02-28
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1)
To Be Published
6FWZ
  • Download 6fwz
  • View 6fwz
Molmil generated image of 6fwz
CRYSTAL STRUCTURE OF HUMAN UDP-N-ACETYLGLUCOSAMINE-DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE (DPAGT1) (V264G MUTANT) IN COMPLEX WITH UDP-GLCNAC
Descriptor:UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, MAGNESIUM ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ...
Authors:Pike, A.C.W., Dong, Y.Y., Chu, A., Tessitore, A., Goubin, S., Dong, L., Mukhopadhyay, S., Mahajan, P., Chalk, R., Berridge, G., Wang, D., Kupinska, K., Belaya, K., Beeson, D., Burgess-Brown, N., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2018-03-07
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of human UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) (V264G mutant) in complex with UDP-GlcNAc
To Be Published
6R65
  • Download 6r65
  • View 6r65
Molmil generated image of 6r65
CRYSTAL STRUCTURE OF HUMAN TMEM16K / ANOCTAMIN 10 (FORM 2)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Bushell, S.R., Pike, A.C.W., Chu, A., Tessitore, A., Rotty, B., Mukhopadhyay, S., Kupinska, K., Shrestha, L., Borkowska, O., Chalk, R., Burgess-Brown, N.A., Love, J., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-26
Release date:2019-05-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal Structure of human TMEM16K / Anoctamin 10 (Form 2)
TO BE PUBLISHED
6R7Y
  • Download 6r7y
  • View 6r7y
Molmil generated image of 6r7y
CRYOEM STRUCTURE OF CALCIUM-BOUND HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (LOW CA2+, CLOSED FORM)
Descriptor:Anoctamin-10, CALCIUM ION
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
6R7Z
  • Download 6r7z
  • View 6r7z
Molmil generated image of 6r7z
CRYOEM STRUCTURE OF CALCIUM-FREE HUMAN TMEM16K / ANOCTAMIN 10 IN DETERGENT (CLOSED FORM)
Descriptor:Anoctamin-10
Authors:Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2019-03-29
Release date:2019-05-01
Last modified:2019-05-15
Method:ELECTRON MICROSCOPY (5.14 Å)
Cite:CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
TO BE PUBLISHED
5BXB
  • Download 5bxb
  • View 5bxb
Molmil generated image of 5bxb
CRYSTAL STRUCTURE OF PENTAMERIC KCTD1 BTB DOMAIN FORM 1
Descriptor:BTB/POZ domain-containing protein KCTD1
Authors:Ji, A.X., Chu, A., Prive, G.G.
Deposit date:2015-06-08
Release date:2015-09-02
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.171 Å)
Cite:Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.
J.Mol.Biol., 428, 2016
5BXD
  • Download 5bxd
  • View 5bxd
Molmil generated image of 5bxd
CRYSTAL STRUCTURE OF PENTAMERIC KCTD1 BTB DOMAIN FORM 2
Descriptor:BTB/POZ domain-containing protein KCTD1
Authors:Ji, A.X., Chu, A., Prive, G.G.
Deposit date:2015-06-08
Release date:2015-09-02
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.
J.Mol.Biol., 428, 2016
5BXH
  • Download 5bxh
  • View 5bxh
Molmil generated image of 5bxh
CRYSTAL STRUCTURE OF PENTAMERIC KCTD9 BTB DOMAIN
Descriptor:BTB/POZ domain-containing protein KCTD9
Authors:Ji, A.X., Chu, A., Prive, G.G.
Deposit date:2015-06-08
Release date:2015-09-02
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.
J.Mol.Biol., 428, 2016
5DPK
  • Download 5dpk
  • View 5dpk
Molmil generated image of 5dpk
MUTY ADENINE GLYCOSYLASE BOUND TO A TRANSITION STATE ANALOG (1N) PAIRED WITH D(8-OXOG) IN DUPLEXED DNA TO 2.2 A
Descriptor:A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(P*GP*TP*CP*CP*AP*(NR1)P*GP*TP*CP*T)-3'), ...
Authors:Horvath, M.P., O'Shea, V.L., Cao, S., David, S.S.
Deposit date:2015-09-12
Release date:2015-09-23
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases.
Nucleic Acids Res., 44, 2016