Author results

1CG5
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DEOXY FORM HEMOGLOBIN FROM DASYATIS AKAJEI
Descriptor:PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE
Authors:Chong, K.T., Morimoto, H.
Deposit date:1999-03-26
Release date:1999-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish.
Acta Crystallogr.,Sect.D, 55, 1999
1CG8
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CO FORM HEMOGLOBIN FROM DASYATIS AKAJEI
Descriptor:PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Chong, K.T., Morimoto, H.
Deposit date:1999-03-26
Release date:1999-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the deoxy and CO forms of haemoglobin from Dasyatis akajei, a cartilaginous fish.
Acta Crystallogr.,Sect.D, 55, 1999
3ARN
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HUMAN DUTPASE IN COMPLEX WITH NOVEL URACIL DERIVATIVE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide, MAGNESIUM ION
Authors:Chong, K.T., Miyahara, S., Miyakoshi, H., Fukuoka, M.
Deposit date:2010-12-03
Release date:2010-12-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors
J.Med.Chem., 55, 2012
3ARA
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DISCOVERY OF NOVEL URACIL DERIVATIVES AS POTENT HUMAN DUTPASE INHIBITORS
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, 1-[3-({(2R)-2-[hydroxy(diphenyl)methyl]pyrrolidin-1-yl}sulfonyl)propyl]pyrimidine-2,4(1H,3H)-dione, MAGNESIUM ION
Authors:Chong, K.T., Miyakoshi, H., Miyahara, S., Fukuoka, M.
Deposit date:2010-11-25
Release date:2010-12-08
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors
J.Med.Chem., 55, 2012
3WQ9
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CRYSTAL STRUCTURE OF HSP90-ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH 2-(4-HYDROXY-CYCLOHEXYLAMINO)-4-[5-(4-PHENYL-IMIDAZOL-1-YL)-ISOQUINOLIN-1-YL]-BENZAMIDE
Descriptor:Heat shock protein HSP 90-alpha, 2-[(trans-4-hydroxycyclohexyl)amino]-4-[5-(4-phenyl-1H-imidazol-1-yl)isoquinolin-1-yl]benzamide
Authors:Chong, K.T., Yamashita, S., Oshiumi, H., Uno, T., Kitade, M.
Deposit date:2014-01-23
Release date:2015-02-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Evolution of highly selective Hsp90 / inhibitors by structure and thermodynamics guided design
To be Published
5H4J
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CRYSTAL STRUCTURE OF HUMAN DUTPASE IN COMPLEX WITH N-[(1R)-1-[3-(CYCLOPENTYLOXY)-PHENYL]-ETHYL]-3-[(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)METHOXY]-1-PROPANESULFONAMIDE
Descriptor:Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, N-[(1R)-1-[3-(Cyclopentyloxy)-phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide, ...
Authors:Chong, K.T., Miyahara, S., Miyakoshi, H., Fukuoka, M.
Deposit date:2016-11-01
Release date:2017-11-01
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy.
Mol. Cancer Ther., 17, 2018
1GCV
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DEOXY FORM HEMOGLOBIN FROM MUSTELUS GRISEUS
Descriptor:HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE
Authors:Naoi, Y., Chong, K.T., Yoshimatsu, K., Miyazaki, G., Tame, J.R.H., Park, S.Y., Adachi, S.I., Morimoto, H.
Deposit date:2000-08-08
Release date:2000-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The functional similarity and structural diversity of human and cartilaginous fish hemoglobins.
J.Mol.Biol., 307, 2001
1GCW
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CO FORM HEMOGLOBIN FROM MUSTELUS GRISEUS
Descriptor:PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Naoi, Y., Chong, K.T., Yoshimatsu, K., Miyazaki, G., Tame, J.R.H., Park, S.Y., Adachi, S.I., Morimoto, H.
Deposit date:2000-08-08
Release date:2000-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The functional similarity and structural diversity of human and cartilaginous fish hemoglobins.
J.Mol.Biol., 307, 2001
1IT2
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HAGFISH DEOXY HEMOGLOBIN
Descriptor:hemoglobin, PROTOPORPHYRIN IX CONTAINING FE
Authors:Mito, M., Chong, K.T., Park, S.-Y., Tame, J.R.
Deposit date:2002-01-05
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of deoxy- and carbonmonoxyhemoglobin F1 from the hagfish Eptatretus burgeri
J.Biol.Chem., 277, 2002
1IT3
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HAGFISH CO LIGAND HEMOGLOBIN
Descriptor:hemoglobin, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
Authors:Mito, M., Chong, K.T., Park, S.-Y., Tame, J.R.
Deposit date:2002-01-05
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of deoxy- and carbonmonoxyhemoglobin F1 from the hagfish Eptatretus burgeri
J.Biol.Chem., 277, 2002
1K9A
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CRYSTAL STRUCTURE ANALYSIS OF FULL-LENGTH CARBOXYL-TERMINAL SRC KINASE AT 2.5 A RESOLUTION
Descriptor:Carboxyl-terminal Src kinase
Authors:Ogawa, A., Takayama, Y., Nagata, A., Chong, K.T., Takeuchi, S., Sakai, H., Nakagawa, A., Nada, S., Okada, M., Tsukihara, T.
Deposit date:2001-10-28
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the carboxyl-terminal Src kinase, Csk.
J.Biol.Chem., 277, 2002
1UHH
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CRYSTAL STRUCTURE OF CP-AEQUORIN
Descriptor:Aequorin 2, (8R)-8-(CYCLOPENTYLMETHYL)-2-HYDROPEROXY-2-(4-HYDROXYBENZYL)-6-(4-HYDROXYPHENYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H)-ONE
Authors:Toma, S., Chong, K.T., Nakagawa, A., Teranishi, K., Inouye, S., Shimomura, O.
Deposit date:2003-07-03
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1UHI
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CRYSTAL STRUCTURE OF I-AEQUORIN
Descriptor:Aequorin 2, (2R)-8-BENZYL-2-HYDROPEROXY-6-(4-HYDROXYPHENYL)-2-(4-IODOBENZYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H)-ONE
Authors:Toma, S., Chong, K.T., Nakagawa, A., Teranishi, K., Inouye, S., Shimomura, O.
Deposit date:2003-07-03
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1UHJ
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CRYSTAL STRUCTURE OF BR-AEQUORIN
Descriptor:Aequorin 2, (2S,8R)-8-BENZYL-2-(4-BROMOBENZYL)-2-HYDROPEROXY-6-(4-HYDROXYPHENYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H)-ONE
Authors:Toma, S., Chong, K.T., Nakagawa, A., Teranishi, K., Inouye, S., Shimomura, O.
Deposit date:2003-07-03
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1UHK
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CRYSTAL STRUCTURE OF N-AEQUORIN
Descriptor:Aequorin 2, (2S,8R)-8-BENZYL-2-HYDROPEROXY-6-(4-HYDROXYPHENYL)-2-(2-NAPHTHYLMETHYL)-7,8-DIHYDROIMIDAZO[1,2-A]PYRAZIN-3(2H)-ONE
Authors:Toma, S., Chong, K.T., Nakagawa, A., Teranishi, K., Inouye, S., Shimomura, O.
Deposit date:2003-07-03
Release date:2005-02-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structures of semi-synthetic aequorins
Protein Sci., 14, 2005
1V4U
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CRYSTAL STRUCTURE OF BLUEFIN TUNA CARBONMONOXY-HEMOGLOBIN
Descriptor:hemoglobin alpha chain, hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Yokoyama, T., Chong, K.T., Miyazaki, Y., Nakatsukasa, T., Unzai, S., Miyazaki, G., Morimoto, H., Jeremy, R.H.T., Park, S.Y.
Deposit date:2003-11-19
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
1V4W
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CRYSTAL STRUCTURE OF BLUEFIN TUNA HEMOGLOBIN DEOXY FORM AT PH7.5
Descriptor:hemoglobin alpha chain, hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
Authors:Yokoyama, T., Chong, K.T., Miyazaki, Y., Nakatsukasa, T., Unzai, S., Miyazaki, G., Morimoto, H., Jeremy, R.H.T., Park, S.Y.
Deposit date:2003-11-19
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
1V4X
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CRYSTAL STRUCTURE OF BLUEFIN TUNA HEMOGLOBIN DEOXY FORM AT PH5.0
Descriptor:hemoglobin alpha chain, hemoglobin beta chain, PROTOPORPHYRIN IX CONTAINING FE
Authors:Yokoyama, T., Chong, K.T., Miyazaki, Y., Nakatsukasa, T., Unzai, S., Miyazaki, G., Morimoto, H., Jeremy, R.H.T., Park, S.Y.
Deposit date:2003-11-19
Release date:2004-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
2E0Z
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CRYSTAL STRUCTURE OF VIRUS-LIKE PARTICLE FROM PYROCOCCUS FURIOSUS
Descriptor:Virus-like particle
Authors:Akita, F., Chong, K.T., Tanaka, H., Yamashita, E., Miyazaki, N., Nakaishi, Y., Namba, K., Ono, Y., Suzuki, M., Tsukihara, T., Nakagawa, A.
Deposit date:2006-10-16
Release date:2007-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The Crystal Structure of a Virus-like Particle from the Hyperthermophilic Archaeon Pyrococcus furiosus Provides Insight into the Evolution of Viruses
J.Mol.Biol., 368, 2007
5ZR3
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CRYSTAL STRUCTURE OF HSP90-ALPHA N-TERMINAL DOMAIN IN COMPLEX WITH 4-(3-ISOPROPYL-4-(4-(1-METHYL-1H-PYRAZOL-4-YL)-1H-IMIDAZOL-1-YL)-1H-PYRAZOLO[3,4-B]PYRIDIN-1-YL)-3-METHYLBENZAMIDE
Descriptor:Heat shock protein HSP 90-alpha, 3-methyl-4-{4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-3-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide
Authors:Uno, T., Chong, K.T., Suzuki, T.
Deposit date:2018-04-23
Release date:2019-01-02
Last modified:2019-05-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
J. Med. Chem., 62, 2019
1HPO
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HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX
Descriptor:HIV-1 PROTEASE, 4-CYANO-N-(3-CYCLOPROPYL(5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-2-OXO-CYCLOOCTA[B]PYRAN-3-YL)METHYL)PHENYL BENZENSULFONAMIDE
Authors:Watenpaugh, K.D., Janakiraman, M.N.
Deposit date:1996-12-10
Release date:1997-04-21
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones.
J.Med.Chem., 40, 1997
1D4S
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HIV-1 PROTEASE V82F/I84V DOUBLE MUTANT/TIPRANAVIR COMPLEX
Descriptor:PROTEIN (HIV-1 PROTEASE), N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
Authors:Watenpaugh, K.D., Janakiraman, M.N.
Deposit date:1999-10-05
Release date:1999-10-12
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
J.Med.Chem., 39, 1996
1D4Y
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HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX
Descriptor:PROTEIN (HIV-1 PROTEASE), N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
Authors:Watenpaugh, K.D., Janakiraman, M.N.
Deposit date:1999-10-06
Release date:1999-10-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
J.Med.Chem., 39, 1996
1UKL
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CRYSTAL STRUCTURE OF IMPORTIN-BETA AND SREBP-2 COMPLEX
Descriptor:Importin beta-1 subunit, Sterol regulatory element binding protein-2
Authors:Lee, S.J., Sekimoto, T., Yamashita, E., Nagoshi, E., Nakagawa, A., Imamoto, N., Yoshimura, M., Sakai, H., Tsukihara, T., Yoneda, Y.
Deposit date:2003-08-26
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structure of Importin-beta Bound to SREBP-2: Nuclear Import of a Transcription Factor
Science, 302, 2003
1UPJ
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HIV-1 PROTEASE COMPLEX WITH U095438 [3-[1-(4-BROMOPHENYL) ISOBUTYL]-4-HYDROXYCOUMARIN
Descriptor:HIV-1 PROTEASE, 3-[1-(4-BROMO-PHENYL)-2-METHYL-PROPYL]-4-HYDROXY-CHROMEN-2-ONE
Authors:Watenpaugh, K.D., Mulichak, A.M., Janakiraman, M.N.
Deposit date:1996-03-04
Release date:1996-10-14
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors.
J.Med.Chem., 38, 1995