1J97 | | PHOSPHO-ASPARTYL INTERMEDIATE ANALOGUE OF PHOSPHOSERINE PHOSPHATASE | | Descriptor: | Phosphoserine Phosphatase, MAGNESIUM ION, PHOSPHATE ION | | Authors: | Cho, H., Wang, W., Kim, R., Yokota, H., Damo, S., Kim, S.-H., Wemmer, D., Kustu, S., Yan, D., Berkeley Structural Genomics Center (BSGC) | | Deposit date: | 2001-05-24 | | Release date: | 2001-07-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | BeF(3)(-) acts as a phosphate analog in proteins phosphorylated on aspartate: structure of a BeF(3)(-) complex with phosphoserine phosphatase.
Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
1NP3 | | CRYSTAL STRUCTURE OF CLASS I ACETOHYDROXY ACID ISOMEROREDUCTASE FROM PSEUDOMONAS AERUGINOSA | | Descriptor: | Ketol-acid reductoisomerase | | Authors: | Ahn, H.J., Eom, S.J., Yoon, H.-J., Lee, B.I., Cho, H., Suh, S.W. | | Deposit date: | 2003-01-17 | | Release date: | 2003-05-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Class I Acetohydroxy Acid Isomeroreductase from Pseudomonas aeruginosa
J.Mol.Biol., 328, 2003
|
|
3HSF | | HEAT SHOCK TRANSCRIPTION FACTOR (HSF) | | Descriptor: | HEAT SHOCK TRANSCRIPTION FACTOR | | Authors: | Damberger, F.F., Pelton, J.G., Liu, C., Cho, H., Harrison, C.J., Nelson, H.C.M., Wemmer, D.E. | | Deposit date: | 1995-08-07 | | Release date: | 1995-11-14 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure and dynamics of the DNA-binding domain of the heat shock factor from Kluyveromyces lactis.
J.Mol.Biol., 254, 1995
|
|
1BTO | |
3BTO | |
5ZXB | | CRYSTAL STRUCTURE OF ACK1 WITH COMPOUND 10D | | Descriptor: | Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | | Authors: | Hong, E.M., Kim, H.L., Sim, T.B. | | Deposit date: | 2018-05-18 | | Release date: | 2018-09-26 | | Last modified: | 2018-10-10 | | Method: | X-RAY DIFFRACTION (2.198 Å) | | Cite: | First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.
J. Med. Chem., 61, 2018
|
|
5UFP | | CRYSTAL STRUCTURE OF PT2399 BOUND TO HIF2A-B*:ARNT-B* COMPLEX | | Descriptor: | Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile | | Authors: | Du, X. | | Deposit date: | 2017-01-05 | | Release date: | 2017-01-25 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | On-target efficacy of a HIF-2 alpha antagonist in preclinical kidney cancer models.
Nature, 539, 2016
|
|
6D0Y | |
4UIP | | THE COMPLEX STRUCTURE OF EXTRACELLULAR DOMAIN OF EGFR WITH REPEBODY (RAC1). | | Descriptor: | EPIDERMAL GROWTH FACTOR RECEPTOR, REPEBODY (RAC1), N-ACETYL-D-GLUCOSAMINE | | Authors: | Kang, Y.J., Cha, Y.J., Cho, H.S., Lee, J.J., Kim, H.S. | | Deposit date: | 2015-03-31 | | Release date: | 2015-11-25 | | Last modified: | 2017-03-15 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Enzymatic Prenylation and Oxime Ligation for the Synthesis of Stable and Homogeneous Protein-Drug Conjugates for Targeted Therapy.
Angew.Chem.Int.Ed.Engl., 54, 2015
|
|
4ZG0 | | CRYSTAL STRUCTURE OF MOUSE SYNDESMOS PROTEIN | | Descriptor: | Protein syndesmos | | Authors: | Lee, I., Kim, H., Yoo, J., Cho, H., Lee, W. | | Deposit date: | 2015-04-22 | | Release date: | 2016-04-20 | | Last modified: | 2016-06-01 | | Method: | X-RAY DIFFRACTION (2.006 Å) | | Cite: | Crystal structure of syndesmos and its interaction with Syndecan-4 proteoglycan
Biochem.Biophys.Res.Commun., 463, 2015
|
|
5G28 | | THE CRYSTAL STRUCTURE OF LIGHT-DRIVEN CHLORIDE PUMP CLR AT PH 6.0. | | Descriptor: | CHLORIDE PUMPING RHODOPSIN, CHLORIDE ION, RETINAL, ... | | Authors: | Kim, K.L., Kwon, S.K., Jun, S.H., Cha, J.S., Kim, H.Y., Kim, J.H., Cho, H.S. | | Deposit date: | 2016-04-07 | | Release date: | 2016-10-19 | | Last modified: | 2017-03-29 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Crystal Structure and Functional Characterization of a Light-Driven Chloride Pump Having an Ntq Motif.
Nat.Commun., 7, 2016
|
|
5G2A | | THE CRYSTAL STRUCTURE OF LIGHT-DRIVEN CHLORIDE PUMP CLR AT PH 6.0 WITH BROMIDE ION. | | Descriptor: | CHLORIDE PUMPING RHODOPSIN, BROMIDE ION, RETINAL | | Authors: | Kim, K.L., Kwon, S.K., Jun, S.H., Cha, J.S., Kim, H.Y., Kim, J.H., Cho, H.S. | | Deposit date: | 2016-04-07 | | Release date: | 2016-10-19 | | Last modified: | 2017-03-29 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Crystal Structure and Functional Characterization of a Light-Driven Chloride Pump Having an Ntq Motif.
Nat.Commun., 7, 2016
|
|
5G2C | | THE CRYSTAL STRUCTURE OF LIGHT-DRIVEN CHLORIDE PUMP CLR (T102D) MUTANT AT PH 4.5. | | Descriptor: | CHLORIDE PUMPING RHODOPSIN, OLEIC ACID, CHLORIDE ION, ... | | Authors: | Kim, K.L., Kwon, S.K., Jun, S.H., Cha, J.S., Kim, H.Y., Kim, J.H., Cho, H.S. | | Deposit date: | 2016-04-07 | | Release date: | 2016-10-19 | | Last modified: | 2017-03-29 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Crystal Structure and Functional Characterization of a Light-Driven Chloride Pump Having an Ntq Motif.
Nat.Commun., 7, 2016
|
|
5G2D | | THE CRYSTAL STRUCTURE OF LIGHT-DRIVEN CHLORIDE PUMP CLR (T102N) MUTANT AT PH 4.5. | | Descriptor: | CHLORIDE PUMP RHODOPSIN, OLEIC ACID, RETINAL, ... | | Authors: | Kim, K.L., Kwon, S.K., Jun, S.H., Cha, J.S., Kim, H.Y., Kim, J.H., Cho, H.S. | | Deposit date: | 2016-04-07 | | Release date: | 2016-10-19 | | Last modified: | 2017-03-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure and Functional Characterization of a Light-Driven Chloride Pump Having an Ntq Motif.
Nat.Commun., 7, 2016
|
|
5G54 | | THE CRYSTAL STRUCTURE OF LIGHT-DRIVEN CHLORIDE PUMP CLR AT PH 4.5 | | Descriptor: | CHLORIDE PUMP RHODOPSIN, CHLORIDE ION, OLEIC ACID, ... | | Authors: | Kim, K.L., Kwon, S.K., Jun, S.H., Cha, J.S., Kim, H.Y., Kim, J.H., Cho, H.S. | | Deposit date: | 2016-05-19 | | Release date: | 2016-10-19 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure and Functional Characterization of a Light-Driven Chloride Pump Having an Ntq Motif.
Nat.Commun., 7, 2016
|
|
2NA1 | | ULD COMPLEX | | Descriptor: | Polycomb complex protein BMI-1, Polyhomeotic-like 2 | | Authors: | Cierpicki, T., Gray, F., Cho, H. | | Deposit date: | 2015-12-17 | | Release date: | 2016-11-16 | | Last modified: | 2018-01-31 | | Method: | SOLUTION NMR | | Cite: | BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization.
Nat Commun, 7, 2016
|
|
4B18 | |
4XV1 | | B-RAF KINASE V600E ONCOGENIC MUTANT IN COMPLEX WITH PLX7904 | | Descriptor: | Serine/threonine-protein kinase B-raf, N'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-N-ethyl-N-methylsulfuric diamide | | Authors: | Zhang, Y., Zhang, C. | | Deposit date: | 2015-01-26 | | Release date: | 2015-10-28 | | Last modified: | 2015-11-04 | | Method: | X-RAY DIFFRACTION (2.47 Å) | | Cite: | RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
|
|
4XV2 | |
4XV3 | | B-RAF KINASE V600E ONCOGENIC MUTANT IN COMPLEX WITH PLX7922 | | Descriptor: | Serine/threonine-protein kinase B-raf, N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide | | Authors: | Zhang, Y., Zhang, C. | | Deposit date: | 2015-01-26 | | Release date: | 2015-10-28 | | Last modified: | 2015-11-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
|
|
4XV9 | | B-RAF KINASE DOMAIN IN COMPLEX WITH PLX5568 | | Descriptor: | Serine/threonine-protein kinase B-raf, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide, SULFATE ION | | Authors: | zhang, Y., zhang, c., wang, w. | | Deposit date: | 2015-01-26 | | Release date: | 2015-10-28 | | Last modified: | 2015-11-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
|
|
4B6H | |
4HQM | | THE CRYSTAL STRUCTURE OF QSRR-MENADIONE COMPLEX | | Descriptor: | QsrR protein, 2-methylnaphthalene-1,4-diol | | Authors: | Ji, Q., Zhang, L., Jones, M.B., Sun, F., Deng, X., Liang, H., Brugarolas, P., Gao, N., Peterson, S.N., Lan, L., Bae, T., He, C. | | Deposit date: | 2012-10-25 | | Release date: | 2013-03-06 | | Last modified: | 2013-05-22 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
3C4C | | B-RAF KINASE IN COMPLEX WITH PLX4720 | | Descriptor: | B-Raf proto-oncogene serine/threonine-protein kinase, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide | | Authors: | Zhang, K.Y.J., Wang, W. | | Deposit date: | 2008-01-29 | | Release date: | 2008-02-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3C4E | | PIM-1 KINASE DOMAIN IN COMPLEX WITH 3-AMINOPHENYL-7-AZAINDOLE | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, IMIDAZOLE, N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine | | Authors: | Zhang, K.Y.J., Wang, W. | | Deposit date: | 2008-01-29 | | Release date: | 2008-02-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
