Author results

3EOC
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CDK2/CYCLINA COMPLEXED WITH A IMIDAZO TRIAZIN-2-AMINE
Descriptor:Cell division protein kinase 2, Cyclin-A2, 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine
Authors:Cheung, M., Kuntz, K., Pobanz, M., Salovich, J., Wilson, B., Andrews, W., Shewchuk, L., Epperly, A., Hassler, D., Leesnitzer, M., Smith, J., Smith, G., Lansing, T., Mook, R.
Deposit date:2008-09-26
Release date:2008-11-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
Bioorg.Med.Chem.Lett., 18, 2008
4D3E
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TETRAMER OF IPAD, MODIFIED FROM 2J0O, FITTED INTO NEGATIVE STAIN ELECTRON MICROSCOPY RECONSTRUCTION OF THE WILD TYPE TIP COMPLEX FROM THE TYPE III SECRETION SYSTEM OF SHIGELLA FLEXNERI
Descriptor:INVASIN IPAD
Authors:Cheung, M., Shen, D.-K., Makino, F., Kato, T., Roehrich, D., Martinez-Argudo, I., Walker, M.L., Murillo, I., Liu, X., Pain, M., Brown, J., Frazer, G., Mantell, J., Mina, P., Todd, T., Sessions, R.B., Namba, K., Blocker, A.J.
Deposit date:2014-10-21
Release date:2014-12-10
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (2.12 Å)
Cite:Three-Dimensional Electron Microscopy Reconstruction and Cysteine-Mediated Crosslinking Provide a Model of the T3Ss Needle Tip Complex.
Mol.Microbiol., 95, 2015
2KUO
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STRUCTURE AND IDENTIFICATION OF ADP-RIBOSE RECOGNITION MOTIFS OF APLF AND ROLE IN THE DNA DAMAGE RESPONSE
Descriptor:Aprataxin and PNK-like factor, ZINC ION
Authors:Li, G.Y., McCulloch, R.D., Fenton, A., Cheung, M., Meng, L., Ikura, M., Koch, C.A.
Deposit date:2010-02-23
Release date:2010-05-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and identification of ADP-ribose recognition motifs of aprataxin PNK-like factor (APLF) required for the interaction with sites of DNA damage response
To be Published
1Y6A
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CRYSTAL STRUCTURE OF VEGFR2 IN COMPLEX WITH A 2-ANILINO-5-ARYL-OXAZOLE INHIBITOR
Descriptor:Vascular endothelial growth factor receptor 2, N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
Authors:Harris, P.A., Cheung, M., Hunter, R.N., Brown, M.L., Veal, J.M., Nolte, R.T., Wang, L., Liu, W., Crosby, R.M., Johnson, J.H., Epperly, A.H., Kumar, R., Luttrell, D.K., Stafford, J.A.
Deposit date:2004-12-05
Release date:2005-06-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
J.Med.Chem., 48, 2005
1Y6B
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CRYSTAL STRUCTURE OF VEGFR2 IN COMPLEX WITH A 2-ANILINO-5-ARYL-OXAZOLE INHIBITOR
Descriptor:Vascular endothelial growth factor receptor 2, N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
Authors:Harris, P.A., Cheung, M., Hunter, R.N., Brown, M.L., Veal, J.M., Nolte, R.T., Wang, L., Liu, W., Crosby, R.M., Johnson, J.H., Epperly, A.H., Kumar, R., Luttrell, D.K., Stafford, J.A.
Deposit date:2004-12-05
Release date:2005-06-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
J.Med.Chem., 48, 2005
3J0R
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MODEL OF A TYPE III SECRETION SYSTEM NEEDLE BASED ON A 7 ANGSTROM RESOLUTION CRYOEM MAP
Descriptor:Protein mxiH
Authors:Fujii, T., Cheung, M., Blanco, A., Kato, T., Blocker, A.J., Namba, K.
Deposit date:2011-11-03
Release date:2012-02-29
Last modified:2012-04-04
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Structure of a type III secretion needle at 7-A resolution provides insights into its assembly and signaling mechanisms.
Proc.Natl.Acad.Sci.USA, 109, 2012
2OH4
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CRYSTAL STRUCTURE OF VEGFR2 WITH A BENZIMIDAZOLE-UREA INHIBITOR
Descriptor:Vascular endothelial growth factor receptor 2, SULFATE ION, METHYL (5-{4-[({[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-1H-BENZIMIDAZOL-2-YL)CARBAMATE
Authors:Nolte, R.T., Wang, L.
Deposit date:2007-01-09
Release date:2007-09-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors.
J.Med.Chem., 50, 2007
4YFF
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TNNI3K COMPLEXED WITH INHIBITOR 2
Descriptor:Serine/threonine-protein kinase TNNI3K, 3-[(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-methyl-4-(morpholin-4-yl)benzenesulfonamide
Authors:Shewchuk, L.M., Wang, L., Lawhorn, B.G.
Deposit date:2015-02-25
Release date:2015-09-23
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K).
J.Med.Chem., 58, 2015
4YFI
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TNNI3K COMPLEXED WITH INHIBITOR 1
Descriptor:Serine/threonine-protein kinase TNNI3K, N-methyl-3-(9H-purin-6-ylamino)benzenesulfonamide
Authors:Shewchuk, L.M., Wang, L., Lawhorn, B.G.
Deposit date:2015-02-25
Release date:2015-09-23
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K).
J.Med.Chem., 58, 2015
2XXS
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SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE SHIGELLA TYPE III SECRETION PROTEIN MXIG
Descriptor:PROTEIN MXIG
Authors:McDowell, M.A., Johnson, S., Deane, J.E., McDonnell, J.M., Lea, S.M.
Deposit date:2010-11-11
Release date:2011-07-06
Last modified:2011-09-07
Method:SOLUTION NMR
Cite:Structural and Functional Studies on the N-Terminal Domain of the Shigella Type III Secretion Protein Mxig.
J.Biol.Chem., 286, 2011
3CJF
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CRYSTAL STRUCTURE OF VEGFR2 IN COMPLEX WITH A 3,4,5-TRIMETHOXY ANILINE CONTAINING PYRIMIDINE
Descriptor:Vascular endothelial growth factor receptor 2, SULFATE ION, N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Authors:Nolte, R.T.
Deposit date:2008-03-12
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
J.Med.Chem., 51, 2008
3CJG
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CRYSTAL STRUCTURE OF VEGFR2 IN COMPLEX WITH A 3,4,5-TRIMETHOXY ANILINE CONTAINING PYRIMIDINE
Descriptor:Vascular endothelial growth factor receptor 2, SULFATE ION, N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Authors:Nolte, R.T.
Deposit date:2008-03-12
Release date:2008-10-07
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
J.Med.Chem., 51, 2008
2MME
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HYBRID STRUCTURE OF THE SHIGELLA FLEXNERI MXIH TYPE THREE SECRETION SYSTEM NEEDLE
Descriptor:MxiH
Authors:Demers, J.P., Habenstein, B., Loquet, A., Vasa, S.K., Becker, S., Baker, D., Lange, A., Sgourakis, N.G.
Deposit date:2014-03-14
Release date:2014-10-08
Method:SOLID-STATE NMR (7.7 Å), ELECTRON MICROSCOPY
Cite:High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy.
Nat Commun, 5, 2014