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1Z9E
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BU of 1z9e by Molmil
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
Descriptor: PC4 and SFRS1 interacting protein 2
Authors:Cherepanov, P, Sun, Z.-Y.J, Rahman, S, Maertens, G, Wagner, G, Engelman, A.
Deposit date:2005-04-01
Release date:2005-05-17
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
Nat.Struct.Mol.Biol., 12, 2005
2B4J
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BU of 2b4j by Molmil
Structural basis for the recognition between HIV-1 integrase and LEDGF/p75
Descriptor: GLYCEROL, Integrase (IN), PC4 and SFRS1 interacting protein, ...
Authors:Cherepanov, P, Ambrosio, A.L, Rahman, S, Ellenberger, T, Engelman, A.
Deposit date:2005-09-24
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75
Proc.Natl.Acad.Sci.Usa, 102, 2005
6GX9
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BU of 6gx9 by Molmil
Crystal structure of the TNPO3 - CPSF6 RSLD complex
Descriptor: BENZAMIDINE, BICINE, Cleavage and polyadenylation specificity factor subunit 6, ...
Authors:Cherepanov, P, Cook, N.
Deposit date:2018-06-26
Release date:2019-03-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Nucleic Acids Res., 47, 2019
6RWO
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BU of 6rwo by Molmil
SIVrcm intasome (Q148H/G140S) in complex with bictegravir
Descriptor: Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWL
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BU of 6rwl by Molmil
SIVrcm intasome
Descriptor: DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3'), Pol protein, ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWN
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BU of 6rwn by Molmil
SIVrcm intasome in complex with dolutegravir
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
6RWM
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BU of 6rwm by Molmil
SIVrcm intasome in complex with bictegravir
Descriptor: Bictegravir, CHLORIDE ION, DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3'), ...
Authors:Cherepanov, P, Nans, A, Cook, N.
Deposit date:2019-06-05
Release date:2020-02-05
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Science, 367, 2020
8A1P
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BU of 8a1p by Molmil
HIV-1 Integrase Catalytic Core Domain and C-Terminal Domain in Complex with Allosteric Integrase Inhibitor BI-D
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Singer, M.R, Pye, V.E, Cook, N.J, Cherepanov, P.
Deposit date:2022-06-01
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Mbio, 14, 2023
7U32
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BU of 7u32 by Molmil
MVV cleaved synaptic complex (CSC) intasome at 3.4 A resolution
Descriptor: CALCIUM ION, DNA EV272, DNA EV273, ...
Authors:Shan, Z, Pye, V.E, Cherepanov, P, Lyumkis, D.
Deposit date:2022-02-25
Release date:2022-05-11
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
8POE
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BU of 8poe by Molmil
Structure of tissue-specific lipid scramblase ATG9B homotrimer, refined with C3 symmetry applied
Descriptor: Autophagy-related protein 9B
Authors:Chiduza, G.N, Pye, V.E, Tooze, S.A, Cherepanov, P.
Deposit date:2023-07-04
Release date:2023-11-15
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.
Autophagy, 20, 2024
5T3A
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BU of 5t3a by Molmil
Maedi-Visna virus (MVV) integrase CCD-CTD (residues 60-275)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACETATE ION, integrase
Authors:Cook, N.J, Pye, V.E, Cherepanov, P.
Deposit date:2016-08-25
Release date:2017-01-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration.
Science, 355, 2017
3DLR
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BU of 3dlr by Molmil
Crystal structure of the catalytic core domain from PFV integrase
Descriptor: Integrase, MAGNESIUM ION
Authors:Valkov, E, Cherepanov, P.
Deposit date:2008-06-29
Release date:2008-12-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Functional and structural characterization of the integrase from the prototype foamy virus.
Nucleic Acids Res., 37, 2009
7ZPP
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BU of 7zpp by Molmil
Cryo-EM structure of the MVV CSC intasome at 4.5A resolution
Descriptor: Integrase, vDNA, non-transferred strand, ...
Authors:Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P.
Deposit date:2022-04-28
Release date:2022-05-11
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:A supramolecular assembly mediates lentiviral DNA integration
Science, 355, 2017
3F9K
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BU of 3f9k by Molmil
Two domain fragment of HIV-2 integrase in complex with LEDGF IBD
Descriptor: Integrase, MAGNESIUM ION, PC4 and SFRS1-interacting protein, ...
Authors:Hare, S, Cherepanov, P.
Deposit date:2008-11-14
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75
Plos Pathog., 5, 2009
7ZBU
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BU of 7zbu by Molmil
CryoEM structure of SARS-CoV-2 spike monomer in complex with neutralising antibody P008_60
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-2-[[5-[(3-ethyl-4-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, P008_60 antibody, ...
Authors:Rosa, A, Pye, V.E, Cronin, N, Cherepanov, P.
Deposit date:2022-03-24
Release date:2022-08-17
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:A neutralizing epitope on the SD1 domain of SARS-CoV-2 spike targeted following infection and vaccination.
Cell Rep, 40, 2022
7Z1Z
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BU of 7z1z by Molmil
MVV strand transfer complex (STC) intasome in complex with LEDGF/p75 at 3.5 A resolution
Descriptor: DNA (37-MER), DNA (5'-D(*GP*CP*TP*GP*CP*GP*AP*GP*AP*TP*CP*CP*GP*CP*TP*CP*CP*GP*GP*TP*G)-3'), DNA (5'-D(P*TP*TP*GP*AP*TP*TP*AP*GP*GP*GP*TP*G)-3'), ...
Authors:Pye, V.E, Ballandras-Colas, A, Cherepanov, P.
Deposit date:2022-02-25
Release date:2022-05-11
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Multivalent interactions essential for lentiviral integrase function.
Nat Commun, 13, 2022
8B7D
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BU of 8b7d by Molmil
Luminal domain of TMEM106B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Pye, V.E, Roustan, C, Cherepanov, P.
Deposit date:2022-09-29
Release date:2023-07-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.
Cell, 186, 2023
7NT9
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BU of 7nt9 by Molmil
Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (closed conformation)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ...
Authors:Rosa, A, Pye, V.E, Nans, A, Cherepanov, P.
Deposit date:2021-03-09
Release date:2021-04-28
Last modified:2021-06-09
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Sci Adv, 7, 2021
7NTA
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BU of 7nta by Molmil
Trimeric SARS-CoV-2 spike ectodomain in complex with biliverdin (one RBD erect)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ...
Authors:Rosa, A, Pye, V.E, Nans, A, Cherepanov, P.
Deposit date:2021-03-09
Release date:2021-04-28
Last modified:2021-06-09
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Sci Adv, 7, 2021
7NTC
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BU of 7ntc by Molmil
Trimeric SARS-CoV-2 spike ectodomain bound to P008_056 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ...
Authors:Rosa, A, Pye, V.E, Nans, A, Cherepanov, P.
Deposit date:2021-03-09
Release date:2021-04-28
Last modified:2021-06-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Sci Adv, 7, 2021
6YA6
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BU of 6ya6 by Molmil
Minimal construct of Cdc7-Dbf4 bound to XL413
Descriptor: 8-chloro-2-[(2S)-pyrrolidin-2-yl][1]benzofuro[3,2-d]pyrimidin-4(3H)-one, BORIC ACID, CHLORIDE ION, ...
Authors:Dick, S.D, Cherepanov, P.
Deposit date:2020-03-11
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
Structure, 28, 2020
6YA8
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BU of 6ya8 by Molmil
Cdc7-Dbf4 bound to ADP-BeF3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase, ...
Authors:Dick, S.D, Cherepanov, P.
Deposit date:2020-03-11
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
Structure, 28, 2020
6YA7
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BU of 6ya7 by Molmil
Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase,Cell division cycle 7-related protein kinase, DNA replication licensing factor MCM2, ...
Authors:Dick, S.D, Cherepanov, P.
Deposit date:2020-03-11
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase.
Structure, 28, 2020
3S3M
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BU of 3s3m by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and Dolutegravir (S/GSK1349572)
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', ...
Authors:Hare, S, Cherepanov, P.
Deposit date:2011-05-18
Release date:2011-07-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572).
Mol.Pharmacol., 80, 2011
3S3O
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BU of 3s3o by Molmil
Crystal structure of the Prototype Foamy Virus (PFV) N224H mutant intasome in complex with magnesium and Dolutegravir (S/GSK1349572)
Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', ...
Authors:Hare, S, Cherepanov, P.
Deposit date:2011-05-18
Release date:2011-07-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572).
Mol.Pharmacol., 80, 2011

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