Author results

4GJH
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CRYSTAL STRUCTURE OF THE TRAF DOMAIN OF TRAF5
分子名称:TNF receptor-associated factor 5
著者Zhang, P., Reichardt, A., Liang, H., Wang, Y., Cheng, D., Aliyari, R., Cheng, G., Liu, Y.
登録日2012-08-09
公開日2012-11-28
実験手法X-RAY DIFFRACTION (2.805 Å)
主引用文献Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Sci.Signal., 5, 2012
5TUB
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CRYSTAL STRUCTURE OF THE SHARK TBC1D15 GAP DOMAIN
分子名称:Shark TBC1D15 GTPase-activating Protein
著者Chen, Y.-N., Wang, W., Cheng, D., Ge, Y., Gu, X., Zhou, X.E., Ye, F., Xu, H.E., Lv, Z.
登録日2016-11-05
公開日2017-02-22
最終更新日2017-04-12
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
5TUC
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CRYSTAL STRUCTURE OF THE SUS TBC1D15 GAP DOMAIN
分子名称:Sus TBC1D15 GAP Domain
著者Chen, Y.-N., Wang, W., Cheng, D., Ge, Y., Gu, X., Zhou, X.E., Ye, F., Xu, H.E., Lv, Z.
登録日2016-11-05
公開日2017-02-22
最終更新日2017-04-12
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Protein Sci., 26, 2017
5U2M
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH A-1293201
分子名称:Nicotinamide phosphoribosyltransferase, N-[4-({[(3S)-oxolan-3-yl]methyl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide, SULFATE ION
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2016-11-30
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16, 2017
5U2N
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH A-1326133
分子名称:Nicotinamide phosphoribosyltransferase, SULFATE ION, N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2016-11-30
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16, 2017
5UPE
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH ISOINDOLINE UREA INHIBITOR COMPOUND 5
分子名称:Nicotinamide phosphoribosyltransferase, N-{4-[(3-phenylpropyl)carbamoyl]phenyl}-2H-isoindole-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-02-02
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg. Med. Chem. Lett., 27, 2017
5UPF
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CRYSTAL STRUCTURE OF HUMAN NAMPT WITH ISOINDOLINE UREA INHIBITOR COMPOUND 53
分子名称:Nicotinamide phosphoribosyltransferase, 5-fluoro-N-{4-[1-(2-hydroxy-2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-isoindole-2-carboxamide
著者Longenecker, K.L., Raich, D., Korepanova, A.V.
登録日2017-02-02
公開日2017-06-28
最終更新日2018-03-21
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg. Med. Chem. Lett., 27, 2017
4GHU
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CRYSTAL STRUCTURE OF TRAF3/CARDIF
分子名称:TNF receptor-associated factor 3, Mitochondrial antiviral-signaling protein
著者Zhang, P.
登録日2012-08-08
公開日2012-11-28
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Sci.Signal., 5, 2012
5K0M
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TARGETING THE PRC2 COMPLEX THROUGH A NOVEL PROTEIN-PROTEIN INTERACTION INHIBITOR OF EED
分子名称:Polycomb protein EED, (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-{4-[4-(methylsulfonyl)piperazin-1-yl]phenyl}pyrrolidin-3-amine
著者Jakob, C.G., Bigelow, L.J., Zhu, H., Sun, C.
登録日2016-05-17
公開日2017-01-25
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat. Chem. Biol., 13, 2017
3DPK
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CFMS TYROSINE KINASE IN COMPLEX WITH A PYRIDOPYRIMIDINONE INHIBITOR
分子名称:Macrophage colony-stimulating factor 1 receptor, Fibroblast growth factor receptor 1, SULFATE ION, ...
著者Schubert, C.
登録日2008-07-08
公開日2009-02-17
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors
J.Med.Chem., 52, 2009
4HK1
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CRYSTAL STRUCTURE OF PCNA FROM DROSOPHILA MELANOGASTER
分子名称:Proliferating cell nuclear antigen
著者Wang, K., Shi, Z.B., Zhou, Z.C.
登録日2012-10-14
公開日2013-04-10
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Structure of PCNA from Drosophila melanogaster.
Acta Crystallogr.,Sect.F, 69, 2013
4NT4
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CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF GILGAMESH ISOFORM I FROM DROSOPHILA MELANOGASTER
分子名称:Gilgamesh, isoform I, SULFATE ION, ...
著者Chen, C.C., Shi, Z.B., Zhou, Z.C.
登録日2013-11-30
公開日2014-04-09
最終更新日2015-03-11
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Structure of the kinase domain of Gilgamesh from Drosophila melanogaster
Acta Crystallogr.,Sect.F, 70, 2014
5JSG
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML405
分子名称:Spindlin-1, [2-(phenylamino)-1,4-phenylene]bis({4-[2-(pyrrolidin-1-yl)ethyl]piperidin-1-yl}methanone), MAGNESIUM ION, ...
著者Su, X., Li, H.
登録日2016-05-08
公開日2017-05-10
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017
5JSJ
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CRYSTAL STRUCTURE OF SPINDLIN1 BOUND TO COMPOUND EML631
分子名称:Spindlin-1, [4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]-[4-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]carbonyl-3-[[4-(pyrrolidin-1-ylmethoxy)phenyl]amino]phenyl]methanone, MAGNESIUM ION, ...
著者Su, X., Li, H.
登録日2016-05-08
公開日2017-05-24
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.348 Å)
主引用文献Developing Spindlin1 small-molecule inhibitors by using protein microarrays
Nat. Chem. Biol., 13, 2017