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2QCS
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A COMPLEX STRUCTURE BETWEEN THE CATALYTIC AND REGULATORY SUBUNIT OF PROTEIN KINASE A THAT REPRESENTS THE INHIBITED STATE
分子名称:cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase type I-alpha regulatory subunit, ...
著者Kim, C., Cheng, C.Y., Saldanha, A.S., Taylor, S.S.
登録日2007-06-19
公開日2007-11-06
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation.
Cell(Cambridge,Mass.), 130, 2007
4JV4
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CRYSTAL STRUCTURE OF RIALPHA(91-379) BOUND TO HE33, A N6 DI-PROPYL SUBSTITUTED CAMP ANALOG
分子名称:cAMP-dependent protein kinase type I-alpha regulatory subunit, (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
著者Brown, S.H.J., Cheng, C.Y., Saldanha, A.S., Wu, J., Cottam, H., Sankaran, B., Taylor, S.S.
登録日2013-03-25
公開日2013-09-18
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (2.952 Å)
主引用文献Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs.
Acs Chem.Biol., 8, 2013
4JVA
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CRYSTAL STRUCTURE OF RIIBETA(108-402) BOUND TO HE33, A N6 DI-PROPYL SUBSTITUTED CAMP ANALOG
分子名称:cAMP-dependent protein kinase type II-beta regulatory subunit, (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide
著者Brown, S.H.J., Cheng, C.Y., Saldanha, A.S., Wu, J., Cottam, H., Sankaran, B., Taylor, S.S.
登録日2013-03-25
公開日2013-09-18
最終更新日2013-10-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs.
Acs Chem.Biol., 8, 2013
3O7L
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CRYSTAL STRUCTURE OF PHOSPHOLAMBAN (1-19):PKA C-SUBUNIT:AMP-PNP:MG2+ COMPLEX
分子名称:cAMP-dependent protein kinase catalytic subunit alpha, Cardiac phospholamban, MAGNESIUM ION, ...
著者Cheng, C.Y., Taylor, S.S.
登録日2010-07-30
公開日2010-10-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Dynamics connect substrate recognition to catalysis in protein kinase A.
Nat.Chem.Biol., 6, 2010
5EK2
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CRYSTAL STRUCTURE OF THE INDOLEAMINE 2,3-DIOXYGENAGSE 1 (IDO1) COMPLEXED WITH NLG919 ANALOGUE
分子名称:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, 1-cyclohexyl-2-[(5~{S})-6-fluoranyl-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanone
著者Peng, Y.H., Wu, J.S., Wu, S.Y.
登録日2015-11-03
公開日2015-12-23
最終更新日2016-01-27
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
J.Med.Chem., 59, 2016
5EK3
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CRYSTAL STRUCTURE OF THE INDOLEAMINE 2,3-DIOXYGENAGSE 1 (IDO1) COMPLEXED WITH NLG919 ANALOGUE
分子名称:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (1~{R})-1-cyclohexyl-2-[(5~{S})-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanol
著者Peng, Y.H., Wu, J.S., Wu, S.Y.
登録日2015-11-03
公開日2015-12-23
最終更新日2016-01-27
実験手法X-RAY DIFFRACTION (2.209 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
J.Med.Chem., 59, 2016
5EK4
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CRYSTAL STRUCTURE OF THE INDOLEAMINE 2,3-DIOXYGENAGSE 1 (IDO1) COMPLEXED WITH NLG919 ANALOGUE
分子名称:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (1~{R})-1-cyclohexyl-2-[(5~{S})-6-fluoranyl-5~{H}-imidazo[1,5-b]isoindol-5-yl]ethanol
著者Wu, S.Y., Peng, Y.H., Wu, J.S.
登録日2015-11-03
公開日2015-12-23
最終更新日2016-01-27
実験手法X-RAY DIFFRACTION (2.64 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1
J.Med.Chem., 59, 2016
5ETW
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CRYSTAL STRUCTURE OF THE INDOLEAMINE 2,3-DIOXYGENAGSE 1 (IDO1) COMPLEXED WITH NLG919 ANALOGUE
分子名称:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, (1~{R})-1-cyclohexyl-2-pyrido[3,4-b]indol-9-yl-ethanol
著者Wu, S.Y., Peng, Y.H., Wu, J.S.
登録日2015-11-18
公開日2016-02-10
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
J.Med.Chem., 59, 2016
6BNO
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STRUCTURE OF BARE ACTIN FILAMENT
分子名称:Actin, alpha skeletal muscle, MAGNESIUM ION, ...
著者Gurel, P.S., Alushin, G.A.
登録日2017-11-17
公開日2018-01-10
最終更新日2018-01-17
実験手法ELECTRON MICROSCOPY (5.5 Å)
主引用文献Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity.
Elife, 6, 2017
6BNP
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CRYOEM STRUCTURE OF MYOSINVI-ACTIN COMPLEX IN THE RIGOR (NUCLEOTIDE-FREE) STATE
分子名称:Unconventional myosin-VI, Actin, alpha skeletal muscle, ...
著者Gurel, P.S., Alushin, G.A.
登録日2017-11-17
公開日2018-01-10
最終更新日2018-01-17
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity.
Elife, 6, 2017
6BNQ
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CRYOEM STRUCTURE OF MYOSIN VI-ACTIN COMPLEX IN THE ADP STATE
分子名称:Unconventional myosin-VI, Actin, alpha skeletal muscle, ...
著者Gurel, P.G., Alushin, G.M.
登録日2017-11-17
公開日2018-01-10
最終更新日2018-01-17
実験手法ELECTRON MICROSCOPY (5.5 Å)
主引用文献Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity.
Elife, 6, 2017
6BNU
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STRUCTURE OF BARE ACTIN FILAMENT, BACKBONE-AVERAGED WITH SIDECHAINS TRUNCATED TO ALANINE
分子名称:Actin, alpha skeletal muscle
著者Gurel, P.S., Alushin, G.A.
登録日2017-11-17
公開日2018-01-10
最終更新日2018-01-17
実験手法ELECTRON MICROSCOPY (7.5 Å)
主引用文献Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity.
Elife, 6, 2017
6BNV
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CRYOEM STRUCTURE OF MYOSINVI-ACTIN COMPLEX IN THE RIGOR (NUCLEOTIDE-FREE) STATE, BACKBONE-AVERAGED WITH SIDE CHAINS TRUNCATED TO ALANINE
分子名称:Unconventional myosin-VI, Actin, alpha skeletal muscle, ...
著者Gurel, P.S., Alushin, G.A.
登録日2017-11-17
公開日2018-01-10
最終更新日2018-01-17
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity.
Elife, 6, 2017
6BNW
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CRYOEM STRUCTURE OF MYOSIN VI-ACTIN COMPLEX IN THE ADP STATE, BACKBONE-AVERAGED WITH SIDE CHAINS TRUNCATED TO ALANINE
分子名称:Unconventional myosin-VI, Actin, alpha skeletal muscle
著者Gurel, P.G., Alushin, G.M.
登録日2017-11-17
公開日2018-01-10
最終更新日2018-01-17
実験手法ELECTRON MICROSCOPY (5.5 Å)
主引用文献Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity.
Elife, 6, 2017