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1XZ0
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BU of 1xz0 by Molmil
Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(HYDROXY-HEXADECANOYL-AMINO)-2-{[(4S)-2-(2-HYDROXY-PHENYL)-4,5-DIHYDRO-OXAZOLE-4-CARBONYL]-AMINO}-HEXANOIC ACID 2-[(3S)-1-(TERT-BUTYL-DIPHENYL-SILANYLOXY)-2-OXO-AZEPAN-3-YLCARBAMOYL]-(1S)-1-METHYL-ETHYL ESTER, Beta-2-microglobulin, ...
Authors:Zajonc, D.M, Crispin, M.D, Bowden, T.A, Young, D.C, Cheng, T.Y, Hu, J, Costello, C.E, Miller, M.J, Moody, D.B, Wilson, I.A.
Deposit date:2004-11-11
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Mechanism of Lipopeptide Presentation by CD1a.
Immunity, 22, 2005
4ZRA
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BU of 4zra by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LPRG BINDING TO TRIACYLGLYCERIDE
Descriptor: Lipoprotein LprG, Tripalmitoylglycerol
Authors:Martinot, A.J, Farrow, M, Bai, L, Layre, E, Cheng, T.Y, Tsai, J.H.C, Iqbal, J, Annand, J, Sullivan, Z, Hussain, M, Sacchettini, J, Moody, D.B, Seeliger, J, Rubin, E.J, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-05-12
Release date:2016-02-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.
Plos Pathog., 12, 2016
4X6E
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BU of 4x6e by Molmil
CD1a binary complex with lysophosphatidylcholine
Descriptor: (4R,7R,18Z)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Beta-2-microglobulin, D-MALATE, ...
Authors:Birkinshaw, R.W, Rossjohn, J.
Deposit date:2014-12-08
Release date:2015-01-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands.
Nat.Immunol., 16, 2015
7SH4
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BU of 7sh4 by Molmil
CD1a-phosphatidylglycerol binary structure
Descriptor: (21R,24R,27S)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Wegrecki, M, Rossjohn, J.
Deposit date:2021-10-07
Release date:2022-10-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a.
Nat.Immunol., 24, 2023
5L2J
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BU of 5l2j by Molmil
Crystal Structure of human CD1b in complex with C36-GMM
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-[(2R,3R)-3-hydroxy-2-tetradecyldocosanoyl]-alpha-L-idopyranose, ACETATE ION, ...
Authors:Gras, S, Shahine, A, Le Nours, J, Rossjohn, J.
Deposit date:2016-08-02
Release date:2016-11-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.
Nat Commun, 7, 2016
5L2K
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BU of 5l2k by Molmil
Crystal structure of GEM42 TCR-CD1b-GMM complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-[(2R,3R)-3-hydroxy-2-tetradecyldocosanoyl]-alpha-L-idopyranose, Beta-2-microglobulin, ...
Authors:Gras, S, Shahine, A, Le Nours, J, Rossjohn, J.
Deposit date:2016-08-02
Release date:2016-11-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.
Nat Commun, 7, 2016
5WKE
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BU of 5wke by Molmil
Crystal Structure of Human CD1b in Complex with PS
Descriptor: (19S,22S,25R)-25-amino-22-hydroxy-16,22,26-trioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shahine, A, Gras, S, Rossjohn, J.
Deposit date:2017-07-25
Release date:2017-11-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.
Sci Immunol, 2, 2017
6OVO
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BU of 6ovo by Molmil
Crystal structure of the unliganded PG10 TCR
Descriptor: 1,2-ETHANEDIOL, Alpha Chain T-Cell Receptor PG10, Beta Chain T-Cell Receptor PG10, ...
Authors:Shahine, A, Rossjohn, J.
Deposit date:2019-05-08
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:A TCR beta-Chain Motif Biases toward Recognition of Human CD1 Proteins.
J Immunol., 203, 2019
6CUH
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BU of 6cuh by Molmil
Crystal structure of the unliganded BC8B TCR
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Shahine, A.E, Rossjohn, J.
Deposit date:2018-03-26
Release date:2019-01-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.
Nat Commun, 10, 2019
6CUG
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BU of 6cug by Molmil
Crystal structure of BC8B TCR-CD1b-PC complex
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ...
Authors:Shahine, A.E, Rossjohn, J.
Deposit date:2018-03-26
Release date:2019-01-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.
Nat Commun, 10, 2019
6D64
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BU of 6d64 by Molmil
Crystal Structure of Human CD1b in Complex with POPC
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-ETHANEDIOL, Beta-2-microglobulin, ...
Authors:Shahine, A.E, Rossjohn, J.
Deposit date:2018-04-20
Release date:2019-01-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.
Nat Commun, 10, 2019
7KP1
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BU of 7kp1 by Molmil
CD1a-42:2 SM binary complex
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, T-cell surface glycoprotein CD1a, ...
Authors:Wegrecki, M, Le Nours, J, Rossjohn, J.
Deposit date:2020-11-10
Release date:2021-05-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
J.Exp.Med., 218, 2021
7KOZ
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BU of 7koz by Molmil
CD1a-36:2 SM binary complex
Descriptor: (4S,7S,17Z)-4-hydroxy-7-[(1S,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphahexacos-17-en-1-aminium, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wegrecki, M, Le Nours, J, Rossjohn, J.
Deposit date:2020-11-10
Release date:2021-05-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
J.Exp.Med., 218, 2021
7KP0
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BU of 7kp0 by Molmil
CD1a-42:1 SM binary complex
Descriptor: (4R,7S)-4-hydroxy-7-[(1S,2E)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-4,9-dioxo-3,5-dioxa-8-aza-4lambda~5~-phosphadotriacontan-1-aminium, 1,2-ETHANEDIOL, Beta-2-microglobulin, ...
Authors:Wegrecki, M, Le Nours, J, Rossjohn, J.
Deposit date:2020-11-10
Release date:2021-05-05
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
J.Exp.Med., 218, 2021
7MX4
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BU of 7mx4 by Molmil
CD1c with antigen analogue 1
Descriptor: (2S)-2,3-dihydroxypropyl hexadecanoate, (4S,8R,12S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl (1R,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl hydrogen (R)-phosphate, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Cao, T.P, Shahine, A, Rossjohn, J.
Deposit date:2021-05-18
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells.
J.Biol.Chem., 297, 2021
7MXF
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BU of 7mxf by Molmil
CD1c with antigen analogue 2
Descriptor: (2S)-2,3-dihydroxypropyl hexadecanoate, 2,6-anhydro-1-deoxy-1-[(S)-hydroxy{[(4R,8S,12R,16R,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-D-glycero-D-galacto-heptitol, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ...
Authors:Cao, T.P, Shahine, A, Rossjohn, J.
Deposit date:2021-05-19
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells.
J.Biol.Chem., 297, 2021
7MXH
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BU of 7mxh by Molmil
CD1c with antigen analogue 3
Descriptor: (2S)-2,3-dihydroxypropyl hexadecanoate, 2,6-anhydro-1-deoxy-1,1-difluoro-1-[(R)-hydroxy{[(4S,8S,12S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-D-glycero-D-galacto-heptitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Cao, T.P, Shahine, A, Rossjohn, J.
Deposit date:2021-05-19
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells.
J.Biol.Chem., 297, 2021
4X6F
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BU of 4x6f by Molmil
CD1a binary complex with sphingomyelin
Descriptor: (4S,7S,23Z)-4-hydroxy-7-[(1S,2Z)-1-hydroxyhexadec-2-en-1-yl]-N,N,N-trimethyl-9-oxo-3,5-dioxa-8-aza-4-phosphadotriacont- 23-en-1-aminium 4-oxide, Beta-2-microglobulin, T-cell surface glycoprotein CD1a
Authors:Birkinshaw, R.W, Rossjohn, J.
Deposit date:2014-12-08
Release date:2015-02-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands.
Nat.Immunol., 16, 2015
4X6C
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BU of 4x6c by Molmil
CD1a ternary complex with lysophosphatidylcholine and BK6 TCR
Descriptor: (4R,7R,18Z)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ...
Authors:Birkinshaw, R.W, Rossjohn, J.
Deposit date:2014-12-08
Release date:2015-01-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands.
Nat.Immunol., 16, 2015
4X6B
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BU of 4x6b by Molmil
BK6 TCR apo structure
Descriptor: TCR alpha, TCR beta
Authors:Birkinshaw, R.W, Rossjohn, J.
Deposit date:2014-12-07
Release date:2015-01-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands.
Nat.Immunol., 16, 2015
4X6D
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BU of 4x6d by Molmil
CD1a ternary complex with endogenous lipids and BK6 TCR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, OLEIC ACID, ...
Authors:Birkinshaw, R.W, Rossjohn, J.
Deposit date:2014-12-08
Release date:2015-01-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:alpha beta T cell antigen receptor recognition of CD1a presenting self lipid ligands.
Nat.Immunol., 16, 2015
3MH9
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BU of 3mh9 by Molmil
Crystal structure of LprG mutant V91W from Mycobacterium tuberculosis
Descriptor: Lipoprotein lprG
Authors:Tsai, H.-C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-04-07
Release date:2010-09-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.794 Å)
Cite:Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
Nat.Struct.Mol.Biol., 17, 2010
3MH8
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BU of 3mh8 by Molmil
Crystal structure of LprG from Mycobacterium tuberculosis
Descriptor: Lipoprotein lprG
Authors:Tsai, H.-C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-04-07
Release date:2010-09-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.995 Å)
Cite:Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
Nat.Struct.Mol.Biol., 17, 2010
3MHA
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BU of 3mha by Molmil
Crystal structure of LprG from Mycobacterium tuberculosis bound to PIM
Descriptor: (1S,2R,3R,4S,5R,6S)-2-(alpha-L-allopyranosyloxy)-3,4,5-trihydroxy-6-({6-O-[(1R)-1-hydroxyhexadecyl]-beta-L-gulopyranosyl}oxy)cyclohexyl (2R)-2-{[(1S)-1-hydroxyhexadecyl]oxy}-3-{[(1S,10S)-1-hydroxy-10-methyloctadecyl]oxy}propyl hydrogen (R)-phosphate, Lipoprotein lprG
Authors:Tsai, H.-C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2010-04-07
Release date:2010-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
Nat.Struct.Mol.Biol., 17, 2010
8GLE
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BU of 8gle by Molmil
Crystal Structure of Human CD1b in Complex with Lysosulfatide
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl 3-O-sulfo-beta-D-galactopyranoside, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shahine, A.
Deposit date:2023-03-22
Release date:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms
Cell(Cambridge,Mass.), 186, 2023

 

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