4HJE | | CRYSTAL STRUCTURE OF P53 CORE DOMAIN IN COMPLEX WITH DNA | | Descriptor: | Cellular tumor antigen p53, DNA (5'-D(*TP*CP*AP*CP*AP*AP*GP*TP*TP*AP*GP*AP*GP*AP*CP*AP*AP*GP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*CP*TP*TP*GP*TP*CP*TP*CP*TP*AP*AP*CP*TP*TP*GP*TP*GP*A)-3'), ... | | Authors: | Chen, Y., Chen, L. | | Deposit date: | 2012-10-12 | | Release date: | 2013-07-17 | | Last modified: | 2013-10-09 | | Method: | X-RAY DIFFRACTION (1.907 Å) | | Cite: | Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.
Nucleic Acids Res., 41, 2013
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4HC7 | | CRYSTAL STRUCTURE OF THE FULL DNA BINDING DOMAIN OF GATA3-COMPLEX 2 | | Descriptor: | Trans-acting T-cell-specific transcription factor GATA-3, DNA (5'-D(*TP*TP*CP*CP*TP*AP*AP*AP*TP*CP*AP*GP*AP*GP*AP*TP*AP*AP*CP*C)-3'), DNA (5'-D(*AP*AP*GP*GP*TP*TP*AP*TP*CP*TP*CP*TP*GP*AP*TP*TP*TP*AP*GP*G)-3'), ... | | Authors: | Chen, Y., Bates, D.L., Dey, R., Chen, L. | | Deposit date: | 2012-09-28 | | Release date: | 2012-12-05 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.
Cell Rep, 2, 2012
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4HC9 | | DNA BINDING BY GATA TRANSCRIPTION FACTOR-COMPLEX 3 | | Descriptor: | Trans-acting T-cell-specific transcription factor GATA-3, DNA (5'-D(*TP*TP*CP*CP*TP*AP*AP*AP*TP*CP*AP*GP*AP*GP*AP*TP*AP*AP*CP*C)-3'), DNA (5'-D(*AP*AP*GP*GP*TP*TP*AP*TP*CP*TP*CP*TP*GP*AP*TP*TP*TP*AP*GP*G)-3'), ... | | Authors: | Chen, Y., Bates, D.L., Dey, R., Chen, L. | | Deposit date: | 2012-09-28 | | Release date: | 2012-12-05 | | Last modified: | 2014-12-17 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.
Cell Rep, 2, 2012
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4HCA | | DNA BINDING BY GATA TRANSCRIPTION FACTOR-COMPLEX 1 | | Descriptor: | Trans-acting T-cell-specific transcription factor GATA-3, DNA (5'-D(*AP*AP*TP*GP*TP*CP*CP*AP*TP*CP*TP*GP*AP*TP*AP*AP*GP*AP*CP*G)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*AP*TP*CP*AP*GP*AP*TP*GP*GP*AP*CP*A)-3'), ... | | Authors: | Chen, Y., Bates, D.L., Dey, R., Chen, L. | | Deposit date: | 2012-09-28 | | Release date: | 2012-12-05 | | Last modified: | 2013-01-02 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | DNA Binding by GATA Transcription Factor Suggests Mechanisms of DNA Looping and Long-Range Gene Regulation.
Cell Rep, 2, 2012
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4WK8 | | FOXP3 FORMS A DOMAIN-SWAPPED DIMER TO BRIDGE DNA | | Descriptor: | DNA (5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'), DNA (5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'), Forkhead box protein P3 | | Authors: | Chen, Y., Chen, L. | | Deposit date: | 2014-10-01 | | Release date: | 2015-01-21 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (3.4006 Å) | | Cite: | DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions.
Nucleic Acids Res., 43, 2015
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6KI3 | | THE CRYSTAL STRUCTURE OF ASFVAP:DF COMMPLEX | | Descriptor: | Probable AP endonuclease, DNA (5'-D(*GP*CP*AP*GP*CP*GP*TP*CP*C)-3'), DNA (5'-D(P*(3DR)P*CP*GP*AP*CP*GP*AP*G)-3'), ... | | Authors: | Chen, Y., Gan, J. | | Deposit date: | 2019-07-17 | | Release date: | 2020-05-27 | | Method: | X-RAY DIFFRACTION (2.354 Å) | | Cite: | A unique DNA-binding mode of African swine fever virus AP endonuclease.
Cell Discov, 6, 2020
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6JYY | | CRYSTAL STRUCTURE OF THE 5-(HYDROXYETHYL)-METHYLTHIAZOLE KINASE THIM FROM KLEBSIELLA PNEUMONIA | | Descriptor: | Hydroxyethylthiazole kinase | | Authors: | Chen, Y., Wang, L., Shang, F., Lan, J., Liu, W., Xu, Y. | | Deposit date: | 2019-04-29 | | Release date: | 2019-06-26 | | Last modified: | 2020-05-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae.
Biochem.Biophys.Res.Commun., 518, 2019
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6K28 | | CRYSTAL STRUCTURE OF THE 5-(HYDROXYETHYL)-METHYLTHIAZOLE KINASE THIM FROM KLEBSIELLA PNEUMONIA IN COMPLEX WITH TZE | | Descriptor: | Hydroxyethylthiazole kinase, 2-(4-METHYL-THIAZOL-5-YL)-ETHANOL, MAGNESIUM ION | | Authors: | Chen, Y., Wang, L., Shang, F., Lan, J., Liu, W., Xu, Y. | | Deposit date: | 2019-05-13 | | Release date: | 2019-07-10 | | Last modified: | 2020-05-06 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae.
Biochem.Biophys.Res.Commun., 518, 2019
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1J48 | | CRYSTAL STRUCTURE OF APO-C1027 | | Descriptor: | Apoprotein of C1027 | | Authors: | Chen, Y., Li, J., Liu, Y., Bartlam, M., Gao, Y., Jin, L., Tang, H., Shao, Y., Zhen, Y., Rao, Z. | | Deposit date: | 2001-07-30 | | Release date: | 2003-06-03 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of Apo-C1027 and Computer Modeling Analysis of C1027 Chromophore- Protein Complex
To be published
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3KMD | |
5GTD | |
6KOR | | CRYSTAL STRUCTURE OF THE RRM DOMAIN OF SYNCRIP | | Descriptor: | Heterogeneous nuclear ribonucleoprotein Q | | Authors: | Chen, Y., Chan, J., Chen, W., Jobichen, C. | | Deposit date: | 2019-08-12 | | Release date: | 2020-01-22 | | Last modified: | 2020-03-04 | | Method: | X-RAY DIFFRACTION (2.602 Å) | | Cite: | SYNCRIP, a new player in pri-let-7a processing.
Rna, 26, 2020
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2HKO | | CRYSTAL STRUCTURE OF LSD1 | | Descriptor: | Lysine-specific histone demethylase 1, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Chen, Y., Yang, Y.T., Wang, F., Yanane, K., Zhang, Y., Lei, M. | | Deposit date: | 2006-07-05 | | Release date: | 2006-08-29 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
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3OWT | | CRYSTAL STRUCTURE OF S. CEREVISIAE RAP1-SIR3 COMPLEX | | Descriptor: | DNA-binding protein RAP1, Regulatory protein SIR3 | | Authors: | Chen, Y., Yang, Y., Lei, M. | | Deposit date: | 2010-09-20 | | Release date: | 2011-01-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
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3RSN | | CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF HUMAN ASH2L | | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2, ZINC ION | | Authors: | Chen, Y., Wan, B., Wang, K.C., Cao, F., Yang, Y., Protacio, A., Dou, Y., Chang, H.Y., Lei, M. | | Deposit date: | 2011-05-02 | | Release date: | 2011-06-22 | | Last modified: | 2011-12-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.
Embo Rep., 12, 2011
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5YPS | | THE STRUCTURAL BASIS OF HISTONE CHAPERONEVPS75 | | Descriptor: | Vacuolar protein sorting-associated protein 75, CALCIUM ION, PENTAETHYLENE GLYCOL, ... | | Authors: | Chen, Y., Zhang, Y., Dou, Y., Wang, M., Xu, S., Jiang, H., Limper, A., Su, D. | | Deposit date: | 2017-11-03 | | Release date: | 2018-11-07 | | Last modified: | 2020-06-10 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inPneumocystis carinii.
Signal Transduct Target Ther, 4, 2019
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5ZB5 | | THE STRUCTURAL BASIS OF HISTONE CHAPERONEVPS75 | | Descriptor: | NAP family histone chaperone vps75, DI(HYDROXYETHYL)ETHER, GLYCEROL | | Authors: | Chen, Y., Zhang, Y., Dou, Y., Wang, M., Xu, S., Jiang, H., Limper, A., Su, D. | | Deposit date: | 2018-02-09 | | Release date: | 2019-02-13 | | Last modified: | 2020-06-10 | | Method: | X-RAY DIFFRACTION (2.299 Å) | | Cite: | Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inPneumocystis carinii.
Signal Transduct Target Ther, 4, 2019
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1CZ8 | | VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY | | Descriptor: | Vascular endothelial growth factor A, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, HEAVY CHAIN OF NEUTRALIZING ANTIBODY, ... | | Authors: | Chen, Y., Wiesmann, C., Fuh, G., Li, B., Christinger, H.W., McKay, P., de Vos, A.M., Lowman, H.B. | | Deposit date: | 1999-09-01 | | Release date: | 2000-03-20 | | Last modified: | 2017-04-05 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
J.Mol.Biol., 293, 1999
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3BQO | | CRYSTAL STRUCTURE OF TRF1 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX | | Descriptor: | Telomeric repeat-binding factor 1, TERF1-interacting nuclear factor 2 | | Authors: | Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M. | | Deposit date: | 2007-12-20 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3BU8 | | CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX | | Descriptor: | Telomeric repeat-binding factor 2, TERF1-interacting nuclear factor 2 | | Authors: | Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M. | | Deposit date: | 2008-01-02 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3BUA | | CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND APOLLO PEPTIDE COMPLEX | | Descriptor: | Telomeric repeat-binding factor 2, DNA cross-link repair 1B protein | | Authors: | Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M. | | Deposit date: | 2008-01-02 | | Release date: | 2008-02-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
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3K6G | | CRYSTAL STRUCTURE OF RAP1 AND TRF2 COMPLEX | | Descriptor: | Telomeric repeat-binding factor 2-interacting protein 1, Telomeric repeat-binding factor 2 | | Authors: | Chen, Y., Rai, R., Yang, Y.T., Zheng, H., Chang, S., Lei, M. | | Deposit date: | 2009-10-08 | | Release date: | 2010-10-13 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
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3TOJ | | STRUCTURE OF THE SPRY DOMAIN OF HUMAN ASH2L | | Descriptor: | Set1/Ash2 histone methyltransferase complex subunit ASH2 | | Authors: | Chen, Y., Cao, F., Wan, B., Dou, Y., Lei, M. | | Deposit date: | 2011-09-05 | | Release date: | 2012-01-25 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
Cell Res., 22, 2012
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4IK1 | | HIGH RESOLUTION STRUCTURE OF GCAMPJ AT PH 8.5 | | Descriptor: | RCaMP, Green fluorescent protein, CALCIUM ION | | Authors: | Chen, Y., Song, X., Miao, L., Zhu, Y., Ji, G. | | Deposit date: | 2012-12-25 | | Release date: | 2014-02-05 | | Last modified: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural insight into enhanced calcium indicator GCaMP3 and GCaMPJ to promote further improvement.
Protein Cell, 4, 2013
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4IK3 | | HIGH RESOLUTION STRUCTURE OF GCAMP3 AT PH 8.5 | | Descriptor: | RCaMP, Green fluorescent protein, CALCIUM ION | | Authors: | Chen, Y., Song, X., Miao, L., Zhu, Y., Ji, G. | | Deposit date: | 2012-12-25 | | Release date: | 2014-01-29 | | Last modified: | 2017-06-21 | | Method: | X-RAY DIFFRACTION (2.007 Å) | | Cite: | Structural insight into enhanced calcium indicator GCaMP3 and GCaMPJ to promote further improvement.
Protein Cell, 4, 2013
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