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2LZ3
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BU of 2lz3 by Molmil
Solution NMR structure of transmembrane domain of amyloid precursor protein WT
Descriptor: Amyloid beta A4 protein
Authors:Chen, W, Wang, C.
Deposit date:2012-09-23
Release date:2013-10-02
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Familial Alzheimer's mutations within APPTM increase A beta 42 production by enhancing accessibility of epsilon-cleavage site.
Nat Commun, 5, 2014
2LZ4
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BU of 2lz4 by Molmil
Solution NMR structure of transmembrane domain of amyloid precursor protein V44M
Descriptor: Amyloid beta A4 protein
Authors:Chen, W, Wang, C.
Deposit date:2012-09-23
Release date:2013-10-02
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Familial Alzheimer's mutations within APPTM increase A beta 42 production by enhancing accessibility of epsilon-cleavage site.
Nat Commun, 5, 2014
3DSH
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BU of 3dsh by Molmil
Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain
Descriptor: Interferon regulatory factor 5
Authors:Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E.
Deposit date:2008-07-12
Release date:2008-10-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Nat.Struct.Mol.Biol., 15, 2008
6JAW
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BU of 6jaw by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with a napthalimide derivative
Descriptor: 2-[3-(morpholin-4-yl)propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, Group II chitinase
Authors:Chen, W, Zhou, Y, Yang, Q.
Deposit date:2019-01-25
Release date:2019-05-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.981 Å)
Cite:Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
6JAV
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BU of 6jav by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with a piperidine-thienopyridine derivative
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(4-chlorophenyl)methyl]sulfanyl}-7-methyl-N-(prop-2-en-1-yl)-7,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-amine, Group II chitinase
Authors:Chen, W, Zhou, Y, Yang, Q.
Deposit date:2019-01-25
Release date:2019-05-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.437 Å)
Cite:Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
6JAY
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BU of 6jay by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with a dipyrido-pyrimidine derivative
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-1-[(furan-2-yl)methyl]-5-oxo-3-({[(2S)-oxolan-2-yl]methyl}carbamoyl)-5H-dipyrido[1,2-a:2',3'-d]pyrimidin-1-ium, Group II chitinase
Authors:Chen, W, Zhou, Y, Yang, Q.
Deposit date:2019-01-25
Release date:2019-05-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.498 Å)
Cite:Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
6JAX
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BU of 6jax by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with chitooctaose [(GlcN)8]
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, Group II chitinase
Authors:Chen, W, Zhou, Y, Yang, Q.
Deposit date:2019-01-25
Release date:2019-05-15
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural dissection reveals a general mechanistic principle for group II chitinase (ChtII) inhibition.
J.Biol.Chem., 294, 2019
5HZQ
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BU of 5hzq by Molmil
Crystal structure of cellular retinoic acid binding protein 2 (CRABP2)-aryl fluorosulfate covalent conjugate
Descriptor: 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, Cellular retinoic acid-binding protein 2, GLYCEROL
Authors:Chen, W, Mortenson, D.E, Wilson, I.A, Kelly, J.W.
Deposit date:2016-02-02
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
J.Am.Chem.Soc., 138, 2016
3GBL
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BU of 3gbl by Molmil
Crystal structure of grass carp Beta2-microglobulin
Descriptor: Beta2-microglobulin
Authors:Chen, W, Gao, F, Xia, C, Gao, G.F.
Deposit date:2009-02-20
Release date:2010-03-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of grass carp Beta2-microglobulin
To be Published
8P8X
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BU of 8p8x by Molmil
Crystal structure of a pathogenic mutant variant of human mitochodnrial PheRS
Descriptor: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial
Authors:Chen, W, Kuhle, B.
Deposit date:2023-06-03
Release date:2023-08-16
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Clinical and molecular characterization of novel FARS2 variants causing neonatal mitochondrial disease.
Mol.Genet.Metab., 140, 2023
6K3Z
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BU of 6k3z by Molmil
Crystal structure of dCas9 in complex with sgRNA and DNA (TGA PAM)
Descriptor: CRISPR-associated endonuclease Cas9, DNA (28-MER), DNA (5'-D(*AP*AP*AP*TP*GP*AP*TP*AP*TP*TP*G)-3'), ...
Authors:Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q.
Deposit date:2019-05-22
Release date:2019-09-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4P
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BU of 6k4p by Molmil
Crystal structure of xCas9 in complex with sgRNA and DNA (TGG PAM)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), PHOSPHATE ION, ...
Authors:Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q.
Deposit date:2019-05-25
Release date:2019-09-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4U
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BU of 6k4u by Molmil
Crystal structure of xCas9 in complex with sgRNA and DNA (TGA PAM)
Descriptor: CRISPR-associated endonuclease Cas9, non-target DNA, sgRNA, ...
Authors:Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q.
Deposit date:2019-05-27
Release date:2019-09-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4S
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BU of 6k4s by Molmil
Crystal structure of xCas9 in complex with sgRNA and DNA (TGC PAM)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, non-targeted DNA, sgRNA, ...
Authors:Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q.
Deposit date:2019-05-26
Release date:2019-09-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K57
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BU of 6k57 by Molmil
Crystal structure of dCas9 in complex with sgRNA and DNA (CGA PAM)
Descriptor: CRISPR-associated endonuclease Cas9, non-target DNA, sgRNA, ...
Authors:Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q.
Deposit date:2019-05-28
Release date:2019-09-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
6K4Q
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BU of 6k4q by Molmil
Crystal structure of xCas9 in complex with sgRNA and DNA (CGG PAM)
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), DNA (5'-D(*AP*AP*AP*CP*GP*GP*TP*AP*TP*TP*G)-3'), ...
Authors:Chen, W, Zhang, H, Zhang, Y, Wang, Y, Gan, J, Ji, Q.
Deposit date:2019-05-26
Release date:2019-09-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease.
Plos Biol., 17, 2019
5Y2B
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BU of 5y2b by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1 in complex with HEPTA-N-ACETYLCHITOOCTAOSE (NAG)7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase
Authors:Chen, W, Qu, M.B, Zhou, Y, Yang, Q.
Deposit date:2017-07-24
Release date:2018-01-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
5Y2C
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BU of 5y2c by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 2 E2180L mutant in complex with PENTA-N-ACETYLCHITOOCTAOSE (NAG)5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase
Authors:Chen, W, Qu, M.B, Zhou, Y, Yang, Q.
Deposit date:2017-07-24
Release date:2018-01-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
5Y2A
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BU of 5y2a by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 2
Descriptor: alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase
Authors:Chen, W, Qu, M.B, Zhou, Y, Yang, Q.
Deposit date:2017-07-24
Release date:2018-01-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
5Y29
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BU of 5y29 by Molmil
Crystal structure of Ostrinia furnacalis Group II chitinase catalytic domain 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, insect group II chitinase
Authors:Chen, W, Qu, M.B, Zhou, Y, Yang, Q.
Deposit date:2017-07-24
Release date:2018-01-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
J. Biol. Chem., 293, 2018
7WJN
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BU of 7wjn by Molmil
CryoEM structure of chitin synthase 1 mutant E495A from Phytophthora sojae complexed with UDP-GlcNAc
Descriptor: Chitin synthase, MANGANESE (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE
Authors:Chen, W, Cao, P, Gong, Y, Yang, Q.
Deposit date:2022-01-07
Release date:2022-09-28
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
7X05
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BU of 7x05 by Molmil
CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with the nascent chitooligosaccharide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitin synthase, MANGANESE (II) ION, ...
Authors:Chen, W, Cao, P, Gong, Y, Yang, Q.
Deposit date:2022-02-21
Release date:2022-09-28
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
7WJO
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BU of 7wjo by Molmil
CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with nikkomycin Z
Descriptor: (2S)-{[(2S,3S,4S)-2-amino-4-hydroxy-4-(5-hydroxypyridin-2-yl)-3-methylbutanoyl]amino}[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]acetic acid (non-preferred name), Chitin synthase
Authors:Chen, W, Cao, P, Gong, Y, Yang, Q.
Deposit date:2022-01-07
Release date:2022-09-28
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
7X06
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BU of 7x06 by Molmil
CryoEM structure of chitin synthase 1 from Phytophthora sojae complexed with UDP
Descriptor: Chitin synthase, MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE
Authors:Chen, W, Cao, P, Gong, Y, Yang, Q.
Deposit date:2022-02-21
Release date:2022-09-28
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for directional chitin biosynthesis.
Nature, 610, 2022
7WJM
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BU of 7wjm by Molmil
CryoEM structure of chitin synthase 1 from Phytophthora sojae
Descriptor: Chitin synthase
Authors:Chen, W, Cao, P, Gong, Y, Yang, Q.
Deposit date:2022-01-07
Release date:2022-09-28
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for directional chitin biosynthesis.
Nature, 610, 2022

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