Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
6M14
DownloadVisualize
BU of 6m14 by Molmil
Crystal Structure of the BARD1 BRCT Mutant
Descriptor: BRCA1-associated RING domain protein 1, SULFATE ION
Authors:Chen, T, Huang, W.T.
Deposit date:2020-02-24
Release date:2021-02-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.88001835 Å)
Cite:BARD1 is an ATPase activating protein for OLA1.
Biochim Biophys Acta Gen Subj, 1866, 2022
2JXD
DownloadVisualize
BU of 2jxd by Molmil
NMR structure of human Serine protease inhibitor Kazal type II (SPINK2)
Descriptor: Serine protease inhibitor Kazal-type 2
Authors:Chen, T, Lee, T.-R, Lyu, P.-C.
Deposit date:2007-11-15
Release date:2008-11-18
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor
Proteins, 77, 2009
8IBH
DownloadVisualize
BU of 8ibh by Molmil
Cep57 C-terminal domain
Descriptor: Centrosomal protein of 57 kDa
Authors:Chen, T, Yeh, H.-W, Cheng, H.-C.
Deposit date:2023-02-10
Release date:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cep57 C-terminal domain
To Be Published
6LW5
DownloadVisualize
BU of 6lw5 by Molmil
Crystal structure of the human formyl peptide receptor 2 in complex with WKYMVm
Descriptor: CHOLESTEROL, Soluble cytochrome b562,N-formyl peptide receptor 2, TRP-LYS-TYR-MET-VAL-QXV
Authors:Chen, T, Zong, X, Zhang, H, Wang, M, Zhao, Q, Wu, B.
Deposit date:2020-02-07
Release date:2020-03-25
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of ligand binding modes at the human formyl peptide receptor 2.
Nat Commun, 11, 2020
5N2M
DownloadVisualize
BU of 5n2m by Molmil
Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, propan-2-yl ~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate
Authors:Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Wiggers, H.J, Picaud, S, Fedorov, O, Krojer, T, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2017-02-07
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
To Be Published
5N2L
DownloadVisualize
BU of 5n2l by Molmil
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 2, SULFATE ION, ...
Authors:Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Wiggers, H.J, Picaud, S, Fedorov, O, Krojer, T, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2017-02-07
Release date:2018-02-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
To Be Published
8SZV
DownloadVisualize
BU of 8szv by Molmil
Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog SJPYT-318
Descriptor: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-[(4-phenoxyphenyl)methyl]benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2
Authors:Huber, A.D, Poudel, S, Miller, D.J, Li, Y, Chen, T.
Deposit date:2023-05-30
Release date:2023-10-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.
Structure, 31, 2023
8EQZ
DownloadVisualize
BU of 8eqz by Molmil
Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog T0-C6
Descriptor: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-hexylbenzenesulfonamide, Nuclear receptor subfamily 1 group I member 2
Authors:Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Lin, W, Li, Y, Chen, T.
Deposit date:2022-10-11
Release date:2023-03-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
8E3N
DownloadVisualize
BU of 8e3n by Molmil
Crystal structure of pregnane X receptor ligand binding domain complexed with rifamycin S
Descriptor: Nuclear receptor subfamily 1 group I member 2, Rifamycin S
Authors:Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Lin, W, Chen, T.
Deposit date:2022-08-17
Release date:2023-03-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F5Y
DownloadVisualize
BU of 8f5y by Molmil
Crystal structure of pregnane X receptor ligand binding domain complexed with JQ1
Descriptor: (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2
Authors:Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Chen, T.
Deposit date:2022-11-15
Release date:2024-02-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Nucleic Acids Res., 52, 2024
8FPE
DownloadVisualize
BU of 8fpe by Molmil
Crystal structure of pregnane X receptor ligand binding domain complexed with T0901317 analog T0-BP
Descriptor: N-[([1,1'-biphenyl]-4-yl)methyl]-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2
Authors:Huber, A.D, Poudel, S, Seetharaman, J, Miller, D.J, Lin, W, Li, Y, Chen, T.
Deposit date:2023-01-04
Release date:2023-03-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Proc.Natl.Acad.Sci.USA, 120, 2023
5EOB
DownloadVisualize
BU of 5eob by Molmil
Crystal structure of CMET in complex with novel inhibitor
Descriptor: 6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline, Hepatocyte growth factor receptor
Authors:Liu, Q, Chen, T, Xu, Y.
Deposit date:2015-11-10
Release date:2016-10-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor
Eur.J.Med.Chem., 116, 2016
6SMH
DownloadVisualize
BU of 6smh by Molmil
Cryo-electron microscopy structure of a RbcL-Raf1 supercomplex from Synechococcus elongatus PCC 7942
Descriptor: Ribulose bisphosphate carboxylase large chain, Rubisco accumulation factor 1 (RAF1) peptide
Authors:Huang, F, Kong, W.-W, Sun, Y, Chen, T, Dykes, G.F, Jiang, Y.L, Liu, L.N.
Deposit date:2019-08-21
Release date:2020-07-08
Last modified:2020-08-05
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Rubisco accumulation factor 1 (Raf1) plays essential roles in mediating Rubisco assembly and carboxysome biogenesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
3JAU
DownloadVisualize
BU of 3jau by Molmil
The cryoEM map of EV71 mature viron in complex with the Fab fragment of antibody D5
Descriptor: Capsid protein VP1, Heavy chain of Fab fragment variable region of antibody D5, Light chain of Fab fragment variable region of antibody D5
Authors:Fan, C, Ye, X.H, Ku, Z.Q, Zuo, T, Kong, L.L, Zhang, C, Shi, J.P, Liu, Q.W, Chen, T, Zhang, Y.Y, Jiang, W, Zhang, L.Q, Huang, Z, Cong, Y.
Deposit date:2015-06-24
Release date:2016-02-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structural Basis for Recognition of Human Enterovirus 71 by a Bivalent Broadly Neutralizing Monoclonal Antibody
Plos Pathog., 12, 2016
7LAD
DownloadVisualize
BU of 7lad by Molmil
Clobetasol propionate bound to CYP3A5
Descriptor: Clobetasol propionate, Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE
Authors:Buchman, C.D, Miller, D, Wang, J, Jayaraman, S, Chen, T.
Deposit date:2021-01-06
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
J.Am.Chem.Soc., 143, 2021
3SHZ
DownloadVisualize
BU of 3shz by Molmil
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Descriptor: 5-chloro-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Chen, T.T, Chen, T, Xu, Y.C.
Deposit date:2011-06-17
Release date:2011-08-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.449 Å)
Cite:Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors.
J.Med.Chem., 54, 2011
3SHY
DownloadVisualize
BU of 3shy by Molmil
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Descriptor: 6-ethyl-5-fluoro-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Chen, T.T, Chen, T, Xu, Y.C.
Deposit date:2011-06-17
Release date:2011-08-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.647 Å)
Cite:Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors.
J.Med.Chem., 54, 2011
3SIE
DownloadVisualize
BU of 3sie by Molmil
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Descriptor: 5-bromo-6-ethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, cGMP-specific 3',5'-cyclic phosphodiesterase
Authors:Chen, T.T, Chen, T, Xu, Y.C.
Deposit date:2011-06-17
Release date:2011-08-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors.
J.Med.Chem., 54, 2011
5EK9
DownloadVisualize
BU of 5ek9 by Molmil
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline inhibitor
Descriptor: Bromodomain-containing protein 2, propan-2-yl ~{N}-[(2~{S},4~{R})-1-ethanoyl-6-(furan-2-yl)-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate
Authors:Tallant, C, Slavish, P.J, Siejka, P, Bharatham, N, Shadrick, W.R, Chai, S, Young, B.M, Boyd, V.A, Heroven, C, Picaud, S, Fedorov, O, Chen, T, Lee, R.E, Guy, R.K, Shelat, A.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:2015-11-03
Release date:2016-11-16
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.
Bioorg. Med. Chem., 26, 2018
1Z9M
DownloadVisualize
BU of 1z9m by Molmil
Crystal Structure of Nectin-like molecule-1 protein Domain 1
Descriptor: GAPA225
Authors:Dong, X, Xu, F, Gong, Y, Gao, J, Lin, P, Chen, T, Peng, Y, Qiang, B, Yuan, J, Peng, X, Rao, Z.
Deposit date:2005-04-03
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the V Domain of Human Nectin-like Molecule-1/Syncam3/Tsll1/Igsf4b, a Neural Tissue-specific Immunoglobulin-like Cell-Cell Adhesion Molecule
J.Biol.Chem., 281, 2006
2FM2
DownloadVisualize
BU of 2fm2 by Molmil
HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211
Descriptor: BETA-MERCAPTOETHANOL, NS3 protease/helicase, NS4a protein, ...
Authors:Yi, M, Tong, X, Skelton, A, Chase, R, Chen, T, Prongay, A, Bogen, S.L, Saksena, A.K, Njoroge, F.G, Veselenak, R.L, Pyles, R.B, Bourne, N, Malcolm, B.A, Lemon, S.M.
Deposit date:2006-01-06
Release date:2006-02-07
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations
J.Biol.Chem., 281, 2006
4IA0
DownloadVisualize
BU of 4ia0 by Molmil
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Descriptor: 5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Ren, J, Chen, T, Xu, Y.
Deposit date:2012-12-05
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
4I9Z
DownloadVisualize
BU of 4i9z by Molmil
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Descriptor: 5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
Authors:Ren, J, Chen, T, Xu, Y.
Deposit date:2012-12-05
Release date:2014-01-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
2OHW
DownloadVisualize
BU of 2ohw by Molmil
Crystal structure of the YueI protein from Bacillus subtilis
Descriptor: YueI protein
Authors:Bonanno, J.B, Jin, X, Mu, H, Dickey, M, Bain, K.T, Wu, B, Chen, T, Reyes, C, Wasserman, S, Smith, D, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2007-01-10
Release date:2007-01-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the YueI protein from Bacillus subtilis
To be Published
6JXM
DownloadVisualize
BU of 6jxm by Molmil
Crystal Structure of phi29 pRNA domain II
Descriptor: BARIUM ION, MAGNESIUM ION, RNA (97-mer)
Authors:Cai, R, Price, I.R, Ding, F, Wu, F, Chen, T, Zhang, Y, Liu, G, Jardine, P.J, Lu, C, Ke, A.
Deposit date:2019-04-24
Release date:2019-08-21
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:ATP/ADP modulates gp16-pRNA conformational change in the Phi29 DNA packaging motor.
Nucleic Acids Res., 47, 2019

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon