Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1IA8
DownloadVisualize
BU of 1ia8 by Molmil
THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1
Descriptor: CHK1 CHECKPOINT KINASE, SULFATE ION
Authors:Chen, P, Luo, C, Deng, Y, Ryan, K, Register, J, Margosiak, S, Tempczyk-Russell, A, Nguyen, B, Myers, P, Lundgren, K, Chen Kan, C.-C, O'Connor, P.M.
Deposit date:2001-03-22
Release date:2001-04-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation.
Cell(Cambridge,Mass.), 100, 2000
6OQ8
DownloadVisualize
BU of 6oq8 by Molmil
Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH 7F
Descriptor: 7F, Toxin B
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6OQ7
DownloadVisualize
BU of 6oq7 by Molmil
Structure of the GTD domain of Clostridium difficile toxin B in complex with VHH E3
Descriptor: E3, MAGNESIUM ION, MANGANESE (II) ION, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
7CI1
DownloadVisualize
BU of 7ci1 by Molmil
Crystal structure of AcrVA2
Descriptor: 1,2-ETHANEDIOL, AcrVA2, SPERMIDINE
Authors:Chen, P, Cheng, Z, Wang, Y.
Deposit date:2020-07-07
Release date:2020-10-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Study on Anti-CRISPR Protein AcrVA2
Prog.Biochem.Biophys., 2021
5L2I
DownloadVisualize
BU of 5l2i by Molmil
The X-ray co-crystal structure of human CDK6 and Palbociclib.
Descriptor: 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, Cyclin-dependent kinase 6
Authors:Chen, P, Ferre, R.A, Deihl, W, Yu, X, He, Y.-A.
Deposit date:2016-08-01
Release date:2016-08-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
5L2S
DownloadVisualize
BU of 5l2s by Molmil
The X-ray co-crystal structure of human CDK6 and Abemaciclib.
Descriptor: Cyclin-dependent kinase 6, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine
Authors:Chen, P, Ferre, R.A, Deihl, W, Yu, X, He, Y.-A.
Deposit date:2016-08-02
Release date:2016-08-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
5L2W
DownloadVisualize
BU of 5l2w by Molmil
The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.
Descriptor: 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, ...
Authors:Chen, P, Ferre, R.A, Deihl, W, Yu, X, He, Y.-A.
Deposit date:2016-08-02
Release date:2016-08-24
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
5L2T
DownloadVisualize
BU of 5l2t by Molmil
The X-ray co-crystal structure of human CDK6 and Ribociclib.
Descriptor: 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, Cyclin-dependent kinase 6
Authors:Chen, P, Ferre, R.A, Deihl, W, Yu, X, He, Y.-A.
Deposit date:2016-08-02
Release date:2016-08-24
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
1GRC
DownloadVisualize
BU of 1grc by Molmil
CRYSTAL STRUCTURE OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE FROM ESCHERICHIA COLI AT 3.0 ANGSTROMS RESOLUTION: A TARGET ENZYME FOR CHEMOTHERAPY
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION
Authors:Chen, P, Wilson, I.A.
Deposit date:1992-07-21
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.
J.Mol.Biol., 227, 1992
4TUU
DownloadVisualize
BU of 4tuu by Molmil
Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design
Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Chen, P, Deng, Y.-L, Bergqvist, S, Falk, M, Liu, W, Timofeevski, S.
Deposit date:2014-06-24
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
4TV3
DownloadVisualize
BU of 4tv3 by Molmil
Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design
Descriptor: 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Chen, P, Deng, Y.-L, Bergqvist, S, Falk, M, Liu, W, Timofeevski, S.
Deposit date:2014-06-25
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
1PI2
DownloadVisualize
BU of 1pi2 by Molmil
REACTIVE SITES OF AN ANTICARCINOGENIC BOWMAN-BIRK PROTEINASE INHIBITOR ARE SIMILAR TO OTHER TRYPSIN INHIBITORS
Descriptor: BOWMAN-BIRK INHIBITOR (PI-II)
Authors:Chen, P, Rose, J, Wang, B.C.
Deposit date:1991-03-26
Release date:1992-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Reactive sites of an anticarcinogenic Bowman-Birk proteinase inhibitor are similar to other trypsin inhibitors.
J.Biol.Chem., 267, 1992
7ML7
DownloadVisualize
BU of 7ml7 by Molmil
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Descriptor: Chondroitin sulfate proteoglycan 4, Toxin B, ZINC ION
Authors:Chen, P, Jin, R.
Deposit date:2021-04-27
Release date:2021-06-09
Last modified:2021-06-30
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection.
Nat Commun, 12, 2021
6OQ5
DownloadVisualize
BU of 6oq5 by Molmil
Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
Descriptor: 5D, 7F, E3, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.87 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
6OQ6
DownloadVisualize
BU of 6oq6 by Molmil
Structure of the pore forming fragment of Clostridium difficile toxin B in complex with VHH 5D
Descriptor: 5D, Toxin B
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2019-04-25
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Structure of the full-length Clostridium difficile toxin B.
Nat.Struct.Mol.Biol., 26, 2019
3S5J
DownloadVisualize
BU of 3s5j by Molmil
2.0A Crystal structure of human phosphoribosyl pyrophosphate synthetase 1
Descriptor: Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P, Teng, M, Li, X.
Deposit date:2011-05-23
Release date:2012-05-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LZO
DownloadVisualize
BU of 4lzo by Molmil
Crystal structure of human PRS1 A87T mutant
Descriptor: Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P, Teng, M, Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LYG
DownloadVisualize
BU of 4lyg by Molmil
Crystal structure of human PRS1 E43T mutant
Descriptor: Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P, Teng, M, Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LZN
DownloadVisualize
BU of 4lzn by Molmil
Crystal structure of human PRS1 D65N mutant
Descriptor: Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P, Teng, M, Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4M0P
DownloadVisualize
BU of 4m0p by Molmil
Crystal structure of human PRS1 M115T mutant
Descriptor: Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P, Teng, M, Li, X.
Deposit date:2013-08-01
Release date:2015-02-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4M0U
DownloadVisualize
BU of 4m0u by Molmil
crystal structure of human PRS1 Q133P mutant
Descriptor: Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P, Teng, M, Li, X.
Deposit date:2013-08-02
Release date:2015-02-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4F8E
DownloadVisualize
BU of 4f8e by Molmil
Crystal structure of human PRS1 D52H mutant
Descriptor: MAGNESIUM ION, Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P, Teng, M, Li, X.
Deposit date:2012-05-17
Release date:2013-05-22
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:A small disturbance, but a serious disease: the possible mechanism of D52H-mutant of human PRS1 that causes gout
Iubmb Life, 65, 2013
7CI2
DownloadVisualize
BU of 7ci2 by Molmil
Crystal structure of AcrVA2 in complex with partial MbCpf1
Descriptor: AcrVA2, MbCpf1
Authors:Chen, P, Cheng, Z, Wang, Y.
Deposit date:2020-07-07
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Study on Anti-CRISPR Protein AcrVA2
Prog.Biochem.Biophys., 2021
6C0B
DownloadVisualize
BU of 6c0b by Molmil
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-2, MALONATE ION, ...
Authors:Chen, P, Lam, K, Jin, R.
Deposit date:2017-12-28
Release date:2018-05-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B.
Science, 360, 2018
7XT3
DownloadVisualize
BU of 7xt3 by Molmil
Crystal Structure of Hepatitis virus A 2C protein 128-335 aa
Descriptor: Genome polyprotein, PHOSPHATE ION
Authors:Chen, P, Wojdyla, J.A, Li, Z, Wang, M, Cui, S.
Deposit date:2022-05-16
Release date:2022-07-27
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Biochemical and structural characterization of hepatitis A virus 2C reveals an unusual ribonuclease activity on single-stranded RNA.
Nucleic Acids Res., 50, 2022

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon