Author results

1IA8
  • Download 1ia8
  • View 1ia8
Molmil generated image of 1ia8
THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1
Descriptor:CHK1 CHECKPOINT KINASE, SULFATE ION
Authors:Chen, P., Luo, C., Deng, Y., Ryan, K., Register, J., Margosiak, S., Tempczyk-Russell, A., Nguyen, B., Myers, P., Lundgren, K., Chen Kan, C.-C., O'Connor, P.M.
Deposit date:2001-03-22
Release date:2001-04-18
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation.
Cell(Cambridge,Mass.), 100, 2000
1GRC
  • Download 1grc
  • View 1grc
Molmil generated image of 1grc
CRYSTAL STRUCTURE OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE FROM ESCHERICHIA COLI AT 3.0 ANGSTROMS RESOLUTION: A TARGET ENZYME FOR CHEMOTHERAPY
Descriptor:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, PHOSPHATE ION
Authors:Chen, P., Wilson, I.A.
Deposit date:1992-07-21
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.
J.Mol.Biol., 227, 1992
1PI2
  • Download 1pi2
  • View 1pi2
Molmil generated image of 1pi2
REACTIVE SITES OF AN ANTICARCINOGENIC BOWMAN-BIRK PROTEINASE INHIBITOR ARE SIMILAR TO OTHER TRYPSIN INHIBITORS
Descriptor:BOWMAN-BIRK INHIBITOR (PI-II)
Authors:Chen, P., Rose, J., Wang, B.C.
Deposit date:1991-03-26
Release date:1992-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Reactive sites of an anticarcinogenic Bowman-Birk proteinase inhibitor are similar to other trypsin inhibitors.
J.Biol.Chem., 267, 1992
3S5J
  • Download 3s5j
  • View 3s5j
Molmil generated image of 3s5j
2.0A CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2011-05-23
Release date:2012-05-23
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4F8E
  • Download 4f8e
  • View 4f8e
Molmil generated image of 4f8e
CRYSTAL STRUCTURE OF HUMAN PRS1 D52H MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION, MAGNESIUM ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2012-05-17
Release date:2013-05-22
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:A small disturbance, but a serious disease: the possible mechanism of D52H-mutant of human PRS1 that causes gout
Iubmb Life, 65, 2013
4LYG
  • Download 4lyg
  • View 4lyg
Molmil generated image of 4lyg
CRYSTAL STRUCTURE OF HUMAN PRS1 E43T MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LZN
  • Download 4lzn
  • View 4lzn
Molmil generated image of 4lzn
CRYSTAL STRUCTURE OF HUMAN PRS1 D65N MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LZO
  • Download 4lzo
  • View 4lzo
Molmil generated image of 4lzo
CRYSTAL STRUCTURE OF HUMAN PRS1 A87T MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4M0P
  • Download 4m0p
  • View 4m0p
Molmil generated image of 4m0p
CRYSTAL STRUCTURE OF HUMAN PRS1 M115T MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-08-01
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4M0U
  • Download 4m0u
  • View 4m0u
Molmil generated image of 4m0u
CRYSTAL STRUCTURE OF HUMAN PRS1 Q133P MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-08-02
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4TUU
  • Download 4tuu
  • View 4tuu
Molmil generated image of 4tuu
ISOLATED P110A SUBUNIT OF PI3KA PROVIDES A PLATFORM FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Chen, P., Deng, Y.-L., Bergqvist, S., Falk, M., Liu, W., Timofeevski, S.
Deposit date:2014-06-24
Release date:2014-08-06
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
4TV3
  • Download 4tv3
  • View 4tv3
Molmil generated image of 4tv3
ISOLATED P110A SUBUNIT OF PI3KA PROVIDES A PLATFORM FOR STRUCTURE-BASED DRUG DESIGN
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one
Authors:Chen, P., Deng, Y.-L., Bergqvist, S., Falk, M., Liu, W., Timofeevski, S.
Deposit date:2014-06-25
Release date:2014-08-06
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
5L2I
  • Download 5l2i
  • View 5l2i
Molmil generated image of 5l2i
THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND PALBOCICLIB.
Descriptor:Cyclin-dependent kinase 6, 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
Authors:Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.
Deposit date:2016-08-01
Release date:2016-08-24
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
5L2S
  • Download 5l2s
  • View 5l2s
Molmil generated image of 5l2s
THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND ABEMACICLIB.
Descriptor:Cyclin-dependent kinase 6, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]pyrimidin-2-amine
Authors:Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.
Deposit date:2016-08-02
Release date:2016-08-24
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
5L2T
  • Download 5l2t
  • View 5l2t
Molmil generated image of 5l2t
THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK6 AND RIBOCICLIB.
Descriptor:Cyclin-dependent kinase 6, 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Authors:Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.
Deposit date:2016-08-02
Release date:2016-08-24
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
5L2W
  • Download 5l2w
  • View 5l2w
Molmil generated image of 5l2w
THE X-RAY CO-CRYSTAL STRUCTURE OF HUMAN CDK2/CYCLINE AND DINACICLIB.
Descriptor:Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ...
Authors:Chen, P., Ferre, R.A., Deihl, W., Yu, X., He, Y.-A.
Deposit date:2016-08-02
Release date:2016-08-24
Last modified:2016-10-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Mol.Cancer Ther., 15, 2016
6C0B
  • Download 6c0b
  • View 6c0b
Molmil generated image of 6c0b
STRUCTURAL BASIS FOR RECOGNITION OF FRIZZLED PROTEINS BY CLOSTRIDIUM DIFFICILE TOXIN B
Descriptor:Toxin B, Frizzled-2, MALONATE ION, ...
Authors:Chen, P., Lam, K., Jin, R.
Deposit date:2017-12-28
Release date:2018-05-16
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B.
Science, 360, 2018
4IR3
  • Download 4ir3
  • View 4ir3
Molmil generated image of 4ir3
CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH 1-[7-AMINO-1-(PYRIMIDIN-2-YL)INDOLIZIN-3-YL]ETHANONE (GSK2833282A)
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Chaikuad, A., Felletar, I., Chung, C.W., Drewry, D., Chen, P., Filippakopoulos, P., Fedorov, O., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-01-14
Release date:2013-01-23
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4IR4
  • Download 4ir4
  • View 4ir4
Molmil generated image of 4ir4
CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH 1-[7-(MORPHOLIN-4-YL)-1-(PYRIDIN-2-YL)INDOLIZIN-3-YL]ETHANONE (GSK2834113A)
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 1-[7-(morpholin-4-yl)-1-(pyridin-2-yl)indolizin-3-yl]ethanone, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Felletar, I., Chung, C.W., Drewry, D., Chen, P., Filippakopoulos, P., Fedorov, O., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-01-14
Release date:2013-01-23
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4IR5
  • Download 4ir5
  • View 4ir5
Molmil generated image of 4ir5
CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH 1-{1-[2-(HYDROXYMETHYL)PHENYL]-7-PHENOXYINDOLIZIN-3-YL}ETHANONE (GSK2847449A)
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 1-{1-[2-(hydroxymethyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone
Authors:Chaikuad, A., Felletar, I., Chung, C.W., Drewry, D., Chen, P., Filippakopoulos, P., Fedorov, O., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-01-14
Release date:2013-01-23
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4IR6
  • Download 4ir6
  • View 4ir6
Molmil generated image of 4ir6
CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH 1-{1-[2-(METHYLSULFONYL)PHENYL]-7-PHENOXYINDOLIZIN-3-YL}ETHANONE (GSK2838097A)
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 1,2-ETHANEDIOL, 1-{1-[2-(methylsulfonyl)phenyl]-7-phenoxyindolizin-3-yl}ethanone
Authors:Chaikuad, A., Felletar, I., Chung, C.W., Drewry, D., Chen, P., Filippakopoulos, P., Fedorov, O., Krojer, T., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-01-14
Release date:2013-01-23
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
4RVR
  • Download 4rvr
  • View 4rvr
Molmil generated image of 4rvr
CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPLEX WITH GSK2801
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, 1-{1-[2-(methylsulfonyl)phenyl]-7-propoxyindolizin-3-yl}ethanone, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Felletar, I., Chung, C.W., Drewry, D., Chen, P., Filippakopoulos, P., Fedorov, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2014-11-27
Release date:2014-12-10
Last modified:2016-03-16
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
J.Med.Chem., 59, 2016
1GAR
  • Download 1gar
  • View 1gar
Molmil generated image of 1gar
TOWARDS STRUCTURE-BASED DRUG DESIGN: CRYSTAL STRUCTURE OF A MULTISUBSTRATE ADDUCT COMPLEX OF GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE AT 1.96 ANGSTROMS RESOLUTION
Descriptor:GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, N-[4-[[3-(2,4-DIAMINO-1,6-DIHYDRO-6-OXO-4-PYRIMIDINYL)-PROPYL]-[2-((2-OXO-2-((4-PHOSPHORIBOXY)-BUTYL)-AMINO)-ETHYL)-THIO-ACETYL]-AMINO]BENZOYL]-1-GLUTAMIC ACID
Authors:Wilson, I.A., Klein, C., Chen, P., Arevalo, J.H.
Deposit date:1994-12-08
Release date:1995-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution.
J.Mol.Biol., 249, 1995
5YLC
  • Download 5ylc
  • View 5ylc
Molmil generated image of 5ylc
CRYSTAL STRUCTURE OF MCR-1 CATALYTIC DOMAIN
Descriptor:Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION
Authors:Wei, P.C., Song, G.J., Shi, M.Y., Zhou, Y.F., Liu, Y., Lei, J., Chen, P., Yin, L.
Deposit date:2017-10-17
Release date:2017-11-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
FASEB J., 32, 2018
5YLE
  • Download 5yle
  • View 5yle
Molmil generated image of 5yle
MCR-1 COMPLEX WITH ETHANOLAMINE (ETA)
Descriptor:Probable phosphatidylethanolamine transferase Mcr-1, ETHANOLAMINE, ZINC ION
Authors:Wei, P.C., Song, G.J., Shi, M.Y., Zhou, Y.F., Liu, Y., Lei, J., Chen, P., Yin, L.
Deposit date:2017-10-17
Release date:2017-11-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.
FASEB J., 32, 2018
<123>