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4QEX
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BU of 4qex by Molmil
Crystal structure of PfEBA-175 RII in complex with a Fab fragment from inhibitory antibody R217
Descriptor: Antibody Heavy Chain, Antibody Light Chain, Erythrocyte-binding antigen-175
Authors:Chen, E, Paing, M.M, Salinas, N, Sim, B.K, Tolia, N.H.
Deposit date:2014-05-19
Release date:2014-06-04
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
4YFS
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BU of 4yfs by Molmil
Structure of the synthetic Duffy Binding Protein (DBP) antigen DEKnull relevant for malaria vaccine design
Descriptor: Duffy receptor
Authors:Chen, E, Tolia, N.H.
Deposit date:2015-02-25
Release date:2015-03-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design.
Plos Negl Trop Dis, 9, 2015
5F3J
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BU of 5f3j by Molmil
Crystal structure of DBP in complex with inhibitory monoclonal antibody 2D10
Descriptor: Antibody 2D10 single chain variable fragment, Duffy receptor
Authors:Chen, E, Salinas, N.D, Tolia, N.H.
Deposit date:2015-12-02
Release date:2016-05-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.001 Å)
Cite:Broadly neutralizing epitopes in the Plasmodium vivax vaccine candidate Duffy Binding Protein.
Proc.Natl.Acad.Sci.USA, 113, 2016
5JPE
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BU of 5jpe by Molmil
Yeast-specific serine/threonine protein phosphatase (PPZ1) of Candida albicans
Descriptor: CITRATE ANION, GLYCEROL, Serine/threonine-protein phosphatase
Authors:Choy, M.S, Chen, E.H, Peti, W, Page, R.
Deposit date:2016-05-03
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.611 Å)
Cite:Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans.
Mbio, 7, 2016
7MRV
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BU of 7mrv by Molmil
F100A mutant structure of MIF2 (D-DT)
Descriptor: D-dopachrome decarboxylase, SULFATE ION
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-09
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
7MRU
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BU of 7mru by Molmil
Crystal structure of S62A MIF2 mutant
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D-dopachrome decarboxylase
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-09
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
7MW7
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BU of 7mw7 by Molmil
Crystal structure of P1G mutant of D-dopachrome tautomerase
Descriptor: D-dopachrome decarboxylase, SODIUM ION, SULFATE ION
Authors:Manjula, R, Murphy, E.L, Murphy, J.W, Lolis, E.
Deposit date:2021-05-15
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
7MSE
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BU of 7mse by Molmil
High-resolution crystal structure of hMIF2 with tartrate at the active site
Descriptor: D-dopachrome decarboxylase, L(+)-TARTARIC ACID
Authors:Murphy, E.L, Manjula, R, Murphy, J.W, Lolis, E.
Deposit date:2021-05-11
Release date:2021-08-18
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.27 Å)
Cite:A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.
J.Biol.Chem., 297, 2021
5JPF
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BU of 5jpf by Molmil
Serine/Threonine phosphatase Z1 (Candida albicans) binds to inhibitor microcystin-LR
Descriptor: MALONATE ION, MANGANESE (II) ION, Microcystin-LR, ...
Authors:Choy, M.S, Chen, E.H, Peti, W, Page, R.
Deposit date:2016-05-03
Release date:2016-08-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.39929724 Å)
Cite:Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans.
Mbio, 7, 2016
4K2U
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BU of 4k2u by Molmil
Crystal structure of PfEBA-175 F1 in complex with R218 antibody Fab fragment
Descriptor: Antibody Heavy Chain, Antibody Light Chain, Erythrocyte binding antigen 175, ...
Authors:Tolia, N.H.
Deposit date:2013-04-09
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175.
Plos Pathog., 9, 2013
1C6X
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BU of 1c6x by Molmil
ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.
Descriptor: N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE, PROTEIN (PROTEASE)
Authors:Munshi, S.
Deposit date:1999-12-28
Release date:2000-12-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.
Acta Crystallogr.,Sect.D, 56, 2000
1C6Y
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BU of 1c6y by Molmil
ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.
Descriptor: N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, PROTEIN (PROTEASE)
Authors:Munshi, S.
Deposit date:1999-12-28
Release date:2000-12-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.
Acta Crystallogr.,Sect.D, 56, 2000
1HSI
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BU of 1hsi by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor: HIV-2 PROTEASE
Authors:Chen, Z.
Deposit date:1995-03-31
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
1HSH
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BU of 1hsh by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor: HIV-II PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Chen, Z.
Deposit date:1995-03-31
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
1HSG
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BU of 1hsg by Molmil
CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor: HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Chen, Z.
Deposit date:1995-03-31
Release date:1996-04-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.
J.Biol.Chem., 269, 1994
2BPW
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BU of 2bpw by Molmil
HIV-1 protease-inhibitor complex
Descriptor: 1-[2-HYDROXY-4-(2-HYDROXY-5-METHYL-CYCLOPENTYLCARBAMOYL)5-PHENYL-PENTYL]-4-(3-PYRIDIN-3-YL-PROPIONYL)-PIPERAZINE-2-CARB OXYLIC ACID TERT-BUTYLAMIDE, HIV-1 PROTEASE
Authors:Munshi, S, Chen, Z.
Deposit date:1998-01-22
Release date:1999-02-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
2BPZ
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BU of 2bpz by Molmil
HIV-1 protease-inhibitor complex
Descriptor: HIV-1 PROTEASE, N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE
Authors:Munshi, S, Chen, Z.
Deposit date:1998-01-22
Release date:1999-02-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
2BPV
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BU of 2bpv by Molmil
HIV-1 protease-inhibitor complex
Descriptor: 1-[2-HYDROXY-4-(2-HYDROXY-5-METHYL-CYCLOPENTYLCARBAMOYL)5-PHENYL-PENTYL]-4-(3-PYRIDIN-3-YL-PROPIONYL)-PIPERAZINE-2-CARB OXYLIC ACID TERT-BUTYLAMIDE, HIV-1 PROTEASE
Authors:Munshi, S, Chen, Z.
Deposit date:1998-01-22
Release date:1999-02-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
2BPY
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BU of 2bpy by Molmil
HIV-1 protease-inhibitor complex
Descriptor: HIV-1 PROTEASE, N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE
Authors:Munshi, S, Chen, Z.
Deposit date:1998-01-22
Release date:1999-02-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
2BPX
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BU of 2bpx by Molmil
HIV-1 protease-inhibitor complex
Descriptor: HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Munshi, S, Chen, Z.
Deposit date:1998-01-22
Release date:1999-02-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rapid X-ray diffraction analysis of HIV-1 protease-inhibitor complexes: inhibitor exchange in single crystals of the bound enzyme.
Acta Crystallogr.,Sect.D, 54, 1998
6QIK
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BU of 6qik by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-01-20
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6QT0
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BU of 6qt0 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-02-22
Release date:2019-06-26
Last modified:2019-10-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6QTZ
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BU of 6qtz by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-02-26
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6S05
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BU of 6s05 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-06-13
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019
6RI5
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BU of 6ri5 by Molmil
Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles
Descriptor: 25S RNA, 5.8S rRNA, 5S rRNA, ...
Authors:Kargas, V, Warren, A.J.
Deposit date:2019-04-23
Release date:2019-06-26
Last modified:2019-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
Elife, 8, 2019

 

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