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7K3D
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BU of 7k3d by Molmil
The structure of NTMT1 in complex with compound DC1-13
Descriptor: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N~2~-{(2S)-1-[(naphthalen-1-yl)acetyl]-2,5-dihydro-1H-pyrrole-2-carbonyl}-L-lysyl-L-argininamide, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Chen, D, Huang, R, Noinaj, N.
Deposit date:2020-09-11
Release date:2021-04-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.
Acs Med.Chem.Lett., 12, 2021
6J14
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BU of 6j14 by Molmil
Complex structure of GY-14 and PD-1
Descriptor: GY-14 heavy chain V fragment, GY-14 light chain V fragment, Programmed cell death protein 1
Authors:Chen, D, Tan, S, Whang, H, Zhang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F.
Deposit date:2018-12-27
Release date:2019-11-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
6J15
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BU of 6j15 by Molmil
Complex structure of GY-5 Fab and PD-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GY-5 heavy chain Fab, ...
Authors:Chen, D, Tan, S, Zhang, H, Wang, H, Chai, Y, Qi, J, Yan, J, Gao, G.F.
Deposit date:2018-12-27
Release date:2019-11-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The FG Loop of PD-1 Serves as a "Hotspot" for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy.
Iscience, 14, 2019
5X5A
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BU of 5x5a by Molmil
Human thymidylate synthase bound with phosphate ion
Descriptor: PHOSPHATE ION, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-15
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X66
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BU of 5x66 by Molmil
Human thymidylate synthase in complex with dUMP and methotrexate
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-21
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X4Y
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BU of 5x4y by Molmil
Mutant human thymidylate synthase M190K crystallized in a sulfate-containing condition
Descriptor: SULFATE ION, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-14
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X5Q
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BU of 5x5q by Molmil
Human thymidylate synthase complexed with dUMP and raltitrexed
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-17
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X67
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BU of 5x67 by Molmil
Human thymidylate synthase in complex with dUMP and nolatrexed
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-21
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
J. Biol. Chem., 292, 2017
5X4X
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BU of 5x4x by Molmil
Mutant human thymidylate synthase A191K crystallized in a sulfate-containing condition
Descriptor: SULFATE ION, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-14
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X69
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BU of 5x69 by Molmil
Human thymidylate synthase with a fragment bound in the dimer interface
Descriptor: 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-21
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X5D
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BU of 5x5d by Molmil
Human thymidylate synthase bound with dUMP
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-15
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X4W
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BU of 5x4w by Molmil
Mutant human thymidylate synthase A191K crystallized in a sulfate-free condition
Descriptor: PHOSPHATE ION, Thymidylate synthase
Authors:Chen, D, Jansson, A, Larsson, A, Nordlund, P.
Deposit date:2017-02-14
Release date:2017-06-28
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
4L0C
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BU of 4l0c by Molmil
Crystal structure of the N-Fopmylmaleamic acid deformylase Nfo(S94A) from Pseudomonas putida S16
Descriptor: ACETIC ACID, DI(HYDROXYETHYL)ETHER, Deformylase
Authors:Chen, D, Lu, Y, Zhang, Z, Wu, G, Xu, P.
Deposit date:2013-05-31
Release date:2014-06-04
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the N-Fopmylmaleamic acid deformylase Nfo from Pseudomonas putida S16
To be Published
6WJ7
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BU of 6wj7 by Molmil
The structure of NTMT1 in complex with compound C2A
Descriptor: AN6-GLZ-PRO-LYS-ARG-ILE-ALA-NH2, N-terminal Xaa-Pro-Lys N-methyltransferase 1
Authors:Srinivasan, K, Chen, D, Huang, R, Noinaj, N.
Deposit date:2020-04-13
Release date:2020-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
J.Med.Chem., 63, 2020
6PVB
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BU of 6pvb by Molmil
The structure of NTMT1 in complex with compound 6
Descriptor: AMINO GROUP-()-(2~{S})-2-azanylpropanal-()-ISOLEUCINE-()-ARGININE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Noinaj, N, Chen, D, Huang, R.
Deposit date:2019-07-20
Release date:2020-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
J.Med.Chem., 63, 2020
6PVS
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BU of 6pvs by Molmil
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL320
Descriptor: 9-(5-{[(3R)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)prop-2-yn-1-yl]amino}-5-deoxy-alpha-D-lyxofuranosyl)-9H-purin-6-amine, NNMT protein
Authors:Noinaj, N, Huang, R, Chen, D, Yadav, R.
Deposit date:2019-07-21
Release date:2019-11-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.575 Å)
Cite:Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase.
J.Med.Chem., 62, 2019
6PVA
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BU of 6pva by Molmil
The structure of NTMT1 in complex with compound 11
Descriptor: AMINO GROUP-()-LYSINE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine, N-terminal Xaa-Pro-Lys N-methyltransferase 1
Authors:Noinaj, N, Chen, D, Huang, R.
Deposit date:2019-07-20
Release date:2020-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The structure of NTMT1 in complex with compound 11
To Be published
6PVE
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BU of 6pve by Molmil
Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL319
Descriptor: 9-(5-{[(3S)-3-amino-3-carboxypropyl][3-(3-carbamoylphenyl)propyl]amino}-5-deoxy-alpha-D-ribofuranosyl)-9H-purin-6-amine, NNMT protein
Authors:Noinaj, N, Huang, R, Chen, D, Yadav, R.
Deposit date:2019-07-20
Release date:2019-11-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase.
J.Med.Chem., 62, 2019
6DTN
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BU of 6dtn by Molmil
The structure of NTMT1 in complex with compound DC100-1
Descriptor: (6D6)PPKRIA(NH2), DC100-1, N-terminal Xaa-Pro-Lys N-methyltransferase 1
Authors:Noinaj, N, Chen, D, Huang, R.
Deposit date:2018-06-18
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.475 Å)
Cite:Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.
J. Med. Chem., 62, 2019
5HS3
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BU of 5hs3 by Molmil
Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, Thymidylate synthase
Authors:Chen, D, Almqvist, H, Axelsson, H, Jafari, R, Mateus, A, Haraldsson, M, Larsson, A, Artursson, P, Molina, D.M, Lundback, T, Nordlund, P.
Deposit date:2016-01-25
Release date:2016-02-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Nat Commun, 7, 2016
6K05
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BU of 6k05 by Molmil
Crystal structure of BRD2(BD1)with ligand BY27 bound
Descriptor: (6~{R})-~{N}-(4-chlorophenyl)-1-methyl-8-(1-methylpyrazol-4-yl)-5,6-dihydro-4~{H}-[1,2,4]triazolo[4,3-a][1]benzazepin-6-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2
Authors:Lu, T, Lu, W, Chen, D, Zhao, Y, Luo, C.
Deposit date:2019-05-05
Release date:2019-09-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.935 Å)
Cite:Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.
Eur.J.Med.Chem., 182, 2019
6K04
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BU of 6k04 by Molmil
Crystal structure of BRD2(BD2)with ligand BY27 bound
Descriptor: (6~{R})-~{N}-(4-chlorophenyl)-1-methyl-8-(1-methylpyrazol-4-yl)-5,6-dihydro-4~{H}-[1,2,4]triazolo[4,3-a][1]benzazepin-6-amine, Bromodomain-containing protein 2
Authors:Lu, T, Lu, W, Chen, D, Zhao, Y, Luo, C.
Deposit date:2019-05-05
Release date:2019-09-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.251 Å)
Cite:Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins.
Eur.J.Med.Chem., 182, 2019
5WRN
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BU of 5wrn by Molmil
Human thymidylate synthase complexed with dCMP
Descriptor: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, Thymidylate synthase
Authors:Chen, D, Nordlund, P.
Deposit date:2016-12-02
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Human thymidylate synthase complexed with dCMP
To Be Published
5ZNC
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BU of 5znc by Molmil
Plasmodium falciparum purine nucleoside phosphorylase in complex with quinine
Descriptor: PHOSPHATE ION, Purine nucleoside phosphorylase, Quinine
Authors:Chen, D, Nordlund, P.
Deposit date:2018-04-08
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.
Sci Transl Med, 11, 2019
5ZNI
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BU of 5zni by Molmil
Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine
Descriptor: Mefloquine, PHOSPHATE ION, Purine nucleoside phosphorylase
Authors:Chen, D, Nordlund, P, Dziekan, J.M.
Deposit date:2018-04-09
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.
Sci Transl Med, 11, 2019

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PDB entries from 2024-03-27

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