Author results

5X4W
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MUTANT HUMAN THYMIDYLATE SYNTHASE A191K CRYSTALLIZED IN A SULFATE-FREE CONDITION
Descriptor:Thymidylate synthase, PHOSPHATE ION
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-14
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X4X
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MUTANT HUMAN THYMIDYLATE SYNTHASE A191K CRYSTALLIZED IN A SULFATE-CONTAINING CONDITION
Descriptor:Thymidylate synthase, SULFATE ION
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-14
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X4Y
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MUTANT HUMAN THYMIDYLATE SYNTHASE M190K CRYSTALLIZED IN A SULFATE-CONTAINING CONDITION
Descriptor:Thymidylate synthase, SULFATE ION
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-14
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X5A
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HUMAN THYMIDYLATE SYNTHASE BOUND WITH PHOSPHATE ION
Descriptor:Thymidylate synthase, PHOSPHATE ION
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-15
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X5D
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HUMAN THYMIDYLATE SYNTHASE BOUND WITH DUMP
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-15
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X5Q
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HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND RALTITREXED
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-17
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X66
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HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTREXATE
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-21
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
5X67
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HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND NOLATREXED
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-21
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
J. Biol. Chem., 292, 2017
5X69
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HUMAN THYMIDYLATE SYNTHASE WITH A FRAGMENT BOUND IN THE DIMER INTERFACE
Descriptor:Thymidylate synthase, 1-(5-methoxy-1H-indol-3-yl)-N,N-dimethyl-methanamine, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE
Authors:Chen, D., Jansson, A., Larsson, A., Nordlund, P.
Deposit date:2017-02-21
Release date:2017-06-28
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
J. Biol. Chem., 292, 2017
4L0C
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CRYSTAL STRUCTURE OF THE N-FOPMYLMALEAMIC ACID DEFORMYLASE NFO(S94A) FROM PSEUDOMONAS PUTIDA S16
Descriptor:Deformylase, ACETIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Chen, D., Lu, Y., Zhang, Z., Wu, G., Xu, P.
Deposit date:2013-05-31
Release date:2014-06-04
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of the N-Fopmylmaleamic acid deformylase Nfo from Pseudomonas putida S16
To be Published
5WRN
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HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DCMP
Descriptor:Thymidylate synthase, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE
Authors:Chen, D., Nordlund, P.
Deposit date:2016-12-02
Release date:2016-12-14
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Human thymidylate synthase complexed with dCMP
To Be Published
4FQ5
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CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO(C200A) FROM PSEUDOMONAS PUTIDA S16 WITH MALEATE
Descriptor:Maleate cis-trans isomerase, MALEIC ACID
Authors:Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
4FQ7
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CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO FROM PSEUDOMONAS PUTIDA S16
Descriptor:Maleate cis-trans isomerase
Authors:Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
5HS3
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HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND 3-AMINO-2-BENZOYL-4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL
Descriptor:Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol
Authors:Chen, D., Almqvist, H., Axelsson, H., Jafari, R., Mateus, A., Haraldsson, M., Larsson, A., Artursson, P., Molina, D.M., Lundback, T., Nordlund, P.
Deposit date:2016-01-25
Release date:2016-02-24
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Nat Commun, 7, 2016
5ZNC
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PLASMODIUM FALCIPARUM PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH QUININE
Descriptor:Purine nucleoside phosphorylase, Quinine, PHOSPHATE ION
Authors:Chen, D., Nordlund, P.
Deposit date:2018-04-08
Release date:2019-01-16
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.
Sci Transl Med, 11, 2019
5ZNI
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PLASMODIUM FALCIPARUM PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH MEFLOQUINE
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, Mefloquine
Authors:Chen, D., Nordlund, P., Dziekan, J.M.
Deposit date:2018-04-09
Release date:2019-01-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.
Sci Transl Med, 11, 2019
6DTN
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THE STRUCTURE OF NTMT1 IN COMPLEX WITH COMPOUND DC100-1
Descriptor:N-terminal Xaa-Pro-Lys N-methyltransferase 1, (6D6)PPKRIA(NH2), DC100-1
Authors:Noinaj, N., Chen, D., Huang, R.
Deposit date:2018-06-18
Release date:2019-04-03
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.475 Å)
Cite:Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.
J. Med. Chem., 62, 2019
4G1T
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CRYSTAL STRUCTURE OF INTERFERON-STIMULATED GENE 54
Descriptor:Interferon-induced protein with tetratricopeptide repeats 2
Authors:Yang, Z., Liang, H., Zhou, Q., Li, Y., Chen, H., Ye, W., Chen, D., Fleming, J., Shu, H., Liu, Y.
Deposit date:2012-07-11
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
Cell Res., 2012
1XAV
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MAJOR G-QUADRUPLEX STRUCTURE FORMED IN HUMAN C-MYC PROMOTER, A MONOMERIC PARALLEL-STRANDED QUADRUPLEX
Descriptor:5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3', POTASSIUM ION
Authors:Ambrus, A., Chen, D., Dai, J., Jones, R.A., Yang, D.
Deposit date:2004-08-26
Release date:2005-02-01
Last modified:2014-09-17
Method:SOLUTION NMR
Cite:Solution structure of the biologically relevant G-Quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.
Biochemistry, 44, 2005
2F8U
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G-QUADRUPLEX STRUCTURE FORMED IN HUMAN BCL-2 PROMOTER, HYBRID FORM
Descriptor:5'-D(*GP*GP*GP*CP*GP*CP*GP*GP*GP*AP*GP*GP*AP*AP*TP*TP*GP*GP*GP*CP*GP*GP*G)-3'
Authors:Dai, J., Chen, D., Carver, M., Yang, D.
Deposit date:2005-12-03
Release date:2006-11-07
Last modified:2014-09-17
Method:SOLUTION NMR
Cite:NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.
Nucleic Acids Res., 34, 2006
4BUL
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NOVEL HYDROXYL TRICYCLICS (E.G. GSK966587) AS POTENT INHIBITORS OF BACTERIAL TYPE IIA TOPOISOMERASES
Descriptor:DNA GYRASE SUBUNIT B, DNA GYRASE SUBUNIT A, 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', ...
Authors:Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Huang, J., Jones, G.E., Sukmar, S.K.K., Spitzfaden, C., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N., Pearson, N.D.
Deposit date:2013-06-20
Release date:2013-08-07
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases.
Bioorg.Med.Chem.Lett., 23, 2013
4IMN
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CRYSTAL STRUCTURE OF WILD TYPE HUMAN LIPOCALIN PGDS BOUND WITH PEG MME 2000
Descriptor:Lipocalin-type prostaglandin-D synthase, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL
Authors:Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P.
Deposit date:2013-01-03
Release date:2013-03-20
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.
J.Lipid Res., 54, 2013
4IMO
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CRYSTAL STRUCTURE OF WILD TYPE HUMAN LIPOCALIN PGDS IN COMPLEX WITH SUBSTRATE ANALOG U44069
Descriptor:Lipocalin-type prostaglandin-D synthase, (5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl}hept-5-enoic acid, THIOCYANATE ION
Authors:Lim, S.M., Chen, D., Teo, H., Roos, A., Nyman, T., Tresaugues, L., Pervushin, K., Nordlund, P.
Deposit date:2013-01-03
Release date:2013-03-20
Last modified:2013-05-22
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase.
J.Lipid Res., 54, 2013
4JDM
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SECRETED CHLAMYDIAL PROTEIN PGP3, FULL-LENGTH
Descriptor:Virulence plasmid protein pGP3-D
Authors:Galaleldeen, A., Taylor, A.B., Chen, D., Holloway, S.P., Zhong, G., Hart, P.J.
Deposit date:2013-02-25
Release date:2013-06-05
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the Chlamydia trachomatis immunodominant antigen Pgp3.
J.Biol.Chem., 288, 2013
4JDN
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SECRETED CHLAMYDIAL PROTEIN PGP3, C-TERMINAL DOMAIN
Descriptor:Virulence plasmid protein pGP3-D, POTASSIUM ION, GLYCEROL
Authors:Galaleldeen, A., Taylor, A.B., Chen, D., Holloway, S.P., Zhong, G., Hart, P.J.
Deposit date:2013-02-25
Release date:2013-06-05
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the Chlamydia trachomatis immunodominant antigen Pgp3.
J.Biol.Chem., 288, 2013