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2Z4V
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND GGPP (INHIBITORY SITE)
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYLGERANYL DIPHOSPHATE
Authors:Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-06-26
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2Z4W
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-749
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, [(6E,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyl]bis(phosphonic acid)
Authors:Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-06-26
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2Z4Y
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-252
Descriptor:Geranylgeranyl pyrophosphate synthetase, (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID), MAGNESIUM ION
Authors:Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-06-26
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2Z4Z
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-SC01
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID)
Authors:Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-06-26
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2Z78
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-806
Descriptor:Geranylgeranyl pyrophosphate synthetase, 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium
Authors:Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-08-16
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2E8V
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH PRODUCT GGPP (P21)
Descriptor:Geranylgeranyl pyrophosphate synthetase, GERANYLGERANYL DIPHOSPHATE
Authors:Chen, C.K.-M., Guo, R.T., Ko, T.P., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-23
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2Z4X
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-252 (P21)
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
Authors:Guo, R.T., Chen, C.K.-M., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-06-26
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2Z50
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-28
Descriptor:Geranylgeranyl pyrophosphate synthetase, (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
Authors:Guo, R.T., Chen, C.K.-M., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-06-26
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2Z52
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-23
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
Authors:Guo, R.T., Chen, C.K.-M., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-06-26
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2Z7I
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH INHIBITOR BPH-742
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM
Authors:Guo, R.T., Chen, C.K.-M., Ko, T.-P., Cao, R., Hudock, M., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-08-23
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
2E8T
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM, FSPP AND IPP
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-23
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E8U
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND IPP (P21)
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE
Authors:Guo, R.T., Chen, C.K.-M., Ko, T.P., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-23
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E8W
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND IPP
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE
Authors:Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E8X
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND GPP
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYL DIPHOSPHATE
Authors:Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E90
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM, PYROPHOSPHATE AND FPP
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, PYROPHOSPHATE, ...
Authors:Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E91
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-91
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, ZOLEDRONIC ACID
Authors:Guo, R.T., Ko, T.P., Cao, R., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E92
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-261
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID)
Authors:Guo, R.T., Ko, T.P., Cao, R., Jeng, W.Y., Chen, C.K.-M., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E93
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-629
Descriptor:Geranylgeranyl pyrophosphate synthetase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID
Authors:Guo, R.T., Cao, R., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E94
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-364
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-BIPHENYL-3-YL-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM
Authors:Guo, R.T., Ko, T.P., Cao, R., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E95
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-675
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 1-HYDROXY-2-[3'-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC ACID
Authors:Guo, R.T., Cao, R., Ko, T.P., Jeng, W.Y., Chang, T.H., Chen, C.K.-M., Liang, P.H., Oldfield, E., Wang, A.H.-J.
Deposit date:2007-01-24
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
4EJT
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STAPHYLOCOCCUS EPIDERMIDIS TCAR IN COMPLEX WITH RNA
Descriptor:Transcriptional regulator TcaR, 5'-R(*AP*A)-3'
Authors:Chang, Y.M., Chen, C.K.-M., Wang, A.H.-J.
Deposit date:2012-04-07
Release date:2013-06-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis.
Plos One, 7, 2012
4EM0
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STAPHYLOCOCCUS AUREUS MARR IN COMPLEX WITH SALICYLATE AND KANAMYCIN
Descriptor:Uncharacterized HTH-type transcriptional regulator SAR2349, 2-HYDROXYBENZOIC ACID, KANAMYCIN A
Authors:Chang, Y.M., Chen, C.K.-M., Wang, A.H.-J.
Deposit date:2012-04-11
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Staphylococcus aureus MarR complexes
To be Published
4EM1
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STAPHYLOCOCCUS AUREUS MARR NATIVE
Descriptor:Uncharacterized HTH-type transcriptional regulator SAR2349
Authors:Chang, Y.M., Chen, C.K.-M., Wang, A.H.-J.
Deposit date:2012-04-11
Release date:2013-04-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Staphylococcus aureus MarR native
To be Published
4EM2
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SELENO-METHIONINE STAPHYLOCOCCUS AUREUS MARR IN COMPLEX WITH SALICYLATE
Descriptor:Uncharacterized HTH-type transcriptional regulator SAR2349, 2-HYDROXYBENZOIC ACID, SULFATE ION
Authors:Chang, Y.M., Ko, T.-P., Chen, C.K.-M., Wang, A.H.-J.
Deposit date:2012-04-11
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Staphylococcus aureus MarR complexes
To be Published
2Z7H
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S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH INHIBITOR BPH-210
Descriptor:Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, {1-HYDROXY-3-[METHYL(4-PHENYLBUTYL)AMINO]PROPANE-1,1-DIYL}BIS(PHOSPHONIC ACID)
Authors:Cao, R., Chen, C.K.-M., Guo, R.-T., Hudock, M., Wang, A.H.-J., Oldfield, E.
Deposit date:2007-08-23
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.
Proteins, 73, 2008
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