2Z4V | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND GGPP (INHIBITORY SITE) | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYLGERANYL DIPHOSPHATE | | Authors: | Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-06-26 | | Release date: | 2008-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2Z4W | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-749 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, [(6E,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyl]bis(phosphonic acid) | | Authors: | Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-06-26 | | Release date: | 2008-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2Z4Y | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-252 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID), MAGNESIUM ION | | Authors: | Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-06-26 | | Release date: | 2008-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2Z4Z | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-SC01 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (6E,11E)-HEPTADECA-6,11-DIENE-9,9-DIYLBIS(PHOSPHONIC ACID) | | Authors: | Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-06-26 | | Release date: | 2008-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2Z78 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-806 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, 3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2,2-diphosphonoethyl)pyridinium | | Authors: | Chen, C.K.-M., Guo, R.T., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-08-16 | | Release date: | 2008-07-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2E8V | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH PRODUCT GGPP (P21) | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, GERANYLGERANYL DIPHOSPHATE | | Authors: | Chen, C.K.-M., Guo, R.T., Ko, T.P., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-23 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2Z4X | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-252 (P21) | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXYNONANE-1,1-DIYL)BIS(PHOSPHONIC ACID) | | Authors: | Guo, R.T., Chen, C.K.-M., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-06-26 | | Release date: | 2008-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2Z50 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-28 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, (1-HYDROXYHEPTANE-1,1-DIYL)BIS(PHOSPHONIC ACID) | | Authors: | Guo, R.T., Chen, C.K.-M., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-06-26 | | Release date: | 2008-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2Z52 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-23 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXYDODECANE-1,1-DIYL)BIS(PHOSPHONIC ACID) | | Authors: | Guo, R.T., Chen, C.K.-M., Hudock, M., Cao, R., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-06-26 | | Release date: | 2008-07-01 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2Z7I | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH INHIBITOR BPH-742 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (2,2-DIPHOSPHONOETHYL)(DODECYL)DIMETHYLPHOSPHONIUM | | Authors: | Guo, R.T., Chen, C.K.-M., Ko, T.-P., Cao, R., Hudock, M., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-08-23 | | Release date: | 2008-07-08 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
J.Med.Chem., 51, 2008
|
|
2E8T | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM, FSPP AND IPP | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... | | Authors: | Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-23 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E8U | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND IPP (P21) | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE | | Authors: | Guo, R.T., Chen, C.K.-M., Ko, T.P., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-23 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E8W | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND IPP | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE | | Authors: | Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E8X | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND GPP | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, GERANYL DIPHOSPHATE | | Authors: | Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E90 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM, PYROPHOSPHATE AND FPP | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, PYROPHOSPHATE, ... | | Authors: | Guo, R.T., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E91 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-91 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, ZOLEDRONIC ACID | | Authors: | Guo, R.T., Ko, T.P., Cao, R., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E92 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-261 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, (1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC ACID) | | Authors: | Guo, R.T., Ko, T.P., Cao, R., Jeng, W.Y., Chen, C.K.-M., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E93 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH BPH-629 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID | | Authors: | Guo, R.T., Cao, R., Ko, T.P., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E94 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-364 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 3-BIPHENYL-3-YL-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM | | Authors: | Guo, R.T., Ko, T.P., Cao, R., Chen, C.K.-M., Jeng, W.Y., Chang, T.H., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
2E95 | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH MAGNESIUM AND BPH-675 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, 1-HYDROXY-2-[3'-(NAPHTHALENE-2-SULFONYLAMINO)-BIPHENYL-3-YL]ETHYLIDENE-1,1-BISPHOSPHONIC ACID | | Authors: | Guo, R.T., Cao, R., Ko, T.P., Jeng, W.Y., Chang, T.H., Chen, C.K.-M., Liang, P.H., Oldfield, E., Wang, A.H.-J. | | Deposit date: | 2007-01-24 | | Release date: | 2007-06-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|
4EJT | |
4EM0 | |
4EM1 | |
4EM2 | |
2Z7H | | S. CEREVISIAE GERANYLGERANYL PYROPHOSPHATE SYNTHASE IN COMPLEX WITH INHIBITOR BPH-210 | | Descriptor: | Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, {1-HYDROXY-3-[METHYL(4-PHENYLBUTYL)AMINO]PROPANE-1,1-DIYL}BIS(PHOSPHONIC ACID) | | Authors: | Cao, R., Chen, C.K.-M., Guo, R.-T., Hudock, M., Wang, A.H.-J., Oldfield, E. | | Deposit date: | 2007-08-23 | | Release date: | 2008-05-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases.
Proteins, 73, 2008
|
|
