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6R75
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BU of 6r75 by Molmil
Crystal structure of human Ube2T E54R mutant
Descriptor: Ubiquitin-conjugating enzyme E2 T
Authors:Chaugule, V.K, Rennie, M.L, Walden, H, Arkinson, C, Kamarainen, O, Toth, R.
Deposit date:2019-03-28
Release date:2019-10-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric mechanism for site-specific ubiquitination of FANCD2.
Nat.Chem.Biol., 16, 2020
5OJJ
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BU of 5ojj by Molmil
Crystal structure of the Zn-bound ubiquitin-conjugating enzyme Ube2T
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, Ubiquitin-conjugating enzyme E2 T, ...
Authors:Morreale, F.E, Testa, A, Chaugule, V.K, Bortoluzzi, A, Ciulli, A, Walden, H.
Deposit date:2017-07-21
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.
J. Med. Chem., 60, 2017
6N13
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BU of 6n13 by Molmil
UbcH7-Ub Complex with R0RBR Parkin and phosphoubiquitin
Descriptor: E3 ubiquitin-protein ligase parkin, Ubiquitin-conjugating enzyme E2 L3, ZINC ION, ...
Authors:Condos, T.E.C, Dunkerley, K.M, Freeman, E.A, Barber, K.R, Aguirre, J.D, Chaugule, V.K, Xiao, Y, Konermann, L, Walden, H, Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2020-01-08
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018
7ZF1
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BU of 7zf1 by Molmil
Structure of ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Lemonidis, K, Rennie, M.L, Arkinson, C, Streetley, J, Clarke, M, Chaugule, V.K, Walden, H.
Deposit date:2022-03-31
Release date:2022-11-16
Last modified:2023-02-08
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.
Embo J., 42, 2023
5C23
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BU of 5c23 by Molmil
Parkin (S65DUblR0RBR)
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ...
Authors:Kumar, A, Aguirre, J.D, Condos, T.E.C, Martinez-Torres, R.J, Chaugule, V.K, Toth, R, Sundaramoorthy, R, Mercier, P, Knebel, A, Spratt, D.E, Barber, K.R, Shaw, G.S, Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C1Z
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BU of 5c1z by Molmil
Parkin (UblR0RBR)
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin, GLYCEROL, ...
Authors:kumar, A, Aguirre, J.D, Condos, T.E.C, Martinez-Torres, R.J, Chaugule, V.K, Toth, R, Sundaramoorthy, R, Mercier, P, Knebel, A, Spratt, D.E, Barber, K.R, Shaw, G.S, Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5NGZ
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BU of 5ngz by Molmil
Ube2T in complex with fragment EM04
Descriptor: 1-(1,3-benzothiazol-2-yl)methanamine, Ubiquitin-conjugating enzyme E2 T
Authors:Morreale, F.E, Bortoluzzi, A, Chaugule, V.K, Arkinson, C, Walden, H, Ciulli, A.
Deposit date:2017-03-21
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
J. Med. Chem., 60, 2017
5N2W
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BU of 5n2w by Molmil
WT-Parkin and pUB complex
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ...
Authors:Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5N38
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BU of 5n38 by Molmil
S65DParkin and pUB complex
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, ...
Authors:Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
7AY0
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BU of 7ay0 by Molmil
Crystal structure of truncated USP1-UAF1
Descriptor: Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ZINC ION
Authors:Arkinson, C, Rennie, M.L, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7AY2
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BU of 7ay2 by Molmil
Crystal structure of truncated USP1-UAF1 reacted with ubiquitin-prg
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 1, WD repeat-containing protein 48, ...
Authors:Arkinson, C, Rennie, M.L, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7AY1
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BU of 7ay1 by Molmil
Cryo-EM structure of USP1-UAF1 bound to mono-ubiquitinated FANCD2, and FANCI
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Rennie, M.L, Arkinson, C, Walden, H.
Deposit date:2020-11-10
Release date:2021-03-24
Last modified:2022-07-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis of FANCD2 deubiquitination by USP1-UAF1.
Nat.Struct.Mol.Biol., 28, 2021
7ZH3
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BU of 7zh3 by Molmil
USP1 bound to ubiquitin conjugated to FANCD2 (focused refinement)
Descriptor: Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ZINC ION
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-04-05
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
7ZH4
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BU of 7zh4 by Molmil
USP1 bound to ML323 and ubiquitin conjugated to FANCD2 (focused refinement)
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, Ubiquitin carboxyl-terminal hydrolase 1, Ubiquitin-60S ribosomal protein L40, ...
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-04-05
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.49 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
8A9J
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BU of 8a9j by Molmil
Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 without ML323 (consensus reconstruction)
Descriptor: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-06-28
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022
8A9K
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BU of 8a9k by Molmil
Cryo-EM structure of USP1-UAF1 bound to FANCI and mono-ubiquitinated FANCD2 with ML323 (consensus reconstruction)
Descriptor: 5-methyl-2-(2-propan-2-ylphenyl)-~{N}-[[4-(1,2,3-triazol-1-yl)phenyl]methyl]pyrimidin-4-amine, DNA (61-MER), Fanconi anemia group D2 protein, ...
Authors:Rennie, M.L, Walden, H.
Deposit date:2022-06-28
Release date:2022-10-12
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
Sci Adv, 8, 2022

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PDB entries from 2024-03-27

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