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4UNM
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BU of 4unm by Molmil
Structure of Galactose Oxidase homologue from Streptomyces lividans
Descriptor: ACETATE ION, COPPER (II) ION, SECRETED PROTEIN
Authors:Chaplin, A.K, Hough, M.A, Worrall, J.A.R.
Deposit date:2014-05-29
Release date:2015-06-10
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Glxa is a New Structural Member of the Radical Copper Oxidase Family and is Required for Glycan Deposition at Hyphal Tips and Morphogenesis of Streptomyces Lividans.
Biochem.J., 469, 2015
7NFC
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BU of 7nfc by Molmil
Cryo-EM structure of NHEJ super-complex (dimer)
Descriptor: DNA (27-MER), DNA (28-MER), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-05
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
7NFE
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BU of 7nfe by Molmil
Cryo-EM structure of NHEJ super-complex (monomer)
Descriptor: DNA (5'-D(P*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*CP*TP*AP*TP*TP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(P*TP*AP*AP*TP*AP*AP*TP*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*AP*G)-3'), DNA ligase 4, ...
Authors:Chaplin, A.K, Hardwick, S.W, Kefala Stavridi, A, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2021-02-06
Release date:2021-08-18
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (4.29 Å)
Cite:Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
Mol.Cell, 81, 2021
6ZH4
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BU of 6zh4 by Molmil
Cryo-EM structure of DNA-PKcs (State 3)
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-20
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZH6
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BU of 6zh6 by Molmil
Cryo-EM structure of DNA-PKcs:Ku80ct194
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-21
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZHA
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BU of 6zha by Molmil
Cryo-EM structure of DNA-PK monomer
Descriptor: DNA, DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs, X-ray repair cross-complementing protein 5, ...
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-21
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZH8
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BU of 6zh8 by Molmil
Cryo-EM structure of DNA-PKcs:DNA
Descriptor: DNA (5'-D(P*AP*CP*TP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*AP*GP*TP*TP*TP*TP*TP*AP*GP*TP*T)-3'), DNA-dependent protein kinase catalytic subunit,DNA-PKcs
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-21
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (4.14 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZFP
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BU of 6zfp by Molmil
Cryo-EM structure of DNA-PKcs (State 2)
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-17
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZHE
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BU of 6zhe by Molmil
Cryo-EM structure of DNA-PK dimer
Descriptor: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-23
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (7.24 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
6ZH2
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BU of 6zh2 by Molmil
Cryo-EM structure of DNA-PKcs (State 1)
Descriptor: DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-dependent protein kinase catalytic subunit,DNA-PKcs
Authors:Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L.
Deposit date:2020-06-20
Release date:2020-10-21
Last modified:2021-01-20
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Dimers of DNA-PK create a stage for DNA double-strand break repair.
Nat.Struct.Mol.Biol., 28, 2021
5LQI
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BU of 5lqi by Molmil
W288A mutant of GlxA from Streptomyces lividans: apo form
Descriptor: Secreted protein
Authors:Chaplin, A.K, Hough, M.A, Worrall, J.A.R.
Deposit date:2016-08-17
Release date:2017-08-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Active-site maturation and activity of the copper-radical oxidase GlxA are governed by a tryptophan residue.
Biochem. J., 474, 2017
5LXZ
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BU of 5lxz by Molmil
W288A mutant of GlxA from Streptomyces lividans: Cu-bound form
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, COPPER (II) ION, ...
Authors:Chaplin, A.K, Hough, M.A, Worrall, J.A.R.
Deposit date:2016-09-23
Release date:2017-07-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:The role of a second-coordination sphere tryptophan residue in the maturation of the catalytic metalloradical site in the auxillary activity family 5 (AA5) GlxA from Streptomyces lividans
to be published
8BOT
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BU of 8bot by Molmil
Cryo-EM structure of NHEJ supercomplex(trimer)
Descriptor: DNA (24-MER), DNA (27-MER), DNA (28-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-11-15
Release date:2023-06-28
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (7.76 Å)
Cite:Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ.
Structure, 31, 2023
6EI0
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BU of 6ei0 by Molmil
Cytosolic copper storage protein Csp from Streptomyces lividans: apo form
Descriptor: Cytosolic copper storage protein (Ccsp), GLYCEROL, SULFATE ION, ...
Authors:Straw, M.L, Chaplin, A.K, Hough, M.A, Worrall, J.A.R.
Deposit date:2017-09-15
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:A cytosolic copper storage protein provides a second level of copper tolerance in Streptomyces lividans.
Metallomics, 10, 2018
6EK9
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BU of 6ek9 by Molmil
Cytosolic copper storage protein Csp from Streptomyces lividans: Cu loaded form
Descriptor: COPPER (I) ION, Cytosolic copper storage protein
Authors:Straw, M.L, Chaplin, A.K, Hough, M.A, Worrall, J.A.R.
Deposit date:2017-09-25
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A cytosolic copper storage protein provides a second level of copper tolerance in Streptomyces lividans.
Metallomics, 10, 2018
5MAP
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BU of 5map by Molmil
X-ray generated oxyferrous complex of DtpA from Streptomyces lividans
Descriptor: DtpA, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Moreno Chicano, T, Chaplin, A.K, Worrall, J.A.R, Strange, R.W, Hough, M.A.
Deposit date:2016-11-04
Release date:2017-05-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Photoreduction and validation of haem-ligand intermediate states in protein crystals by in situ single-crystal spectroscopy and diffraction.
IUCrJ, 4, 2017
5MJH
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BU of 5mjh by Molmil
X-ray generated oxyferrous/water mixed complex of DtpA from Streptomyces lividans
Descriptor: Dye type peroxidase A, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Moreno Chicano, T, Chaplin, A.K, Worrall, J.A.R, Strange, R.W, Hough, M.A.
Deposit date:2016-12-01
Release date:2017-05-10
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Photoreduction and validation of haem-ligand intermediate states in protein crystals by in situ single-crystal spectroscopy and diffraction.
IUCrJ, 4, 2017
7ZVT
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BU of 7zvt by Molmil
CryoEM structure of Ku heterodimer bound to DNA
Descriptor: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ...
Authors:Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
Deposit date:2022-05-17
Release date:2023-05-24
Last modified:2023-12-06
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Nucleic Acids Res., 51, 2023
7ZWA
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BU of 7zwa by Molmil
CryoEM structure of Ku heterodimer bound to DNA and PAXX
Descriptor: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ...
Authors:Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
Deposit date:2022-05-19
Release date:2023-05-31
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
7ZYG
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BU of 7zyg by Molmil
CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
Descriptor: DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ...
Authors:Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K.
Deposit date:2022-05-24
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
8BH3
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BU of 8bh3 by Molmil
DNA-PK Ku80 mediated dimer bound to PAXX
Descriptor: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-10-28
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (4.55 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
8BHV
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BU of 8bhv by Molmil
DNA-PK XLF mediated dimer bound to PAXX
Descriptor: DNA (24-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-11-01
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (4.51 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
8BHY
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BU of 8bhy by Molmil
DNA-PK Ku80 mediated dimer bound to PAXX and XLF
Descriptor: DNA (25-MER), DNA (26-MER), DNA (27-MER), ...
Authors:Hardwick, S.W, Chaplin, A.K.
Deposit date:2022-11-01
Release date:2023-06-07
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (5.33 Å)
Cite:PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Sci Adv, 9, 2023
6ZJI
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BU of 6zji by Molmil
Cryo-EM structure of wild-type KatG from M. tuberculosis
Descriptor: Catalase-peroxidase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Blundell, T.L, Chaplin, A.K, Munir, A.
Deposit date:2020-06-29
Release date:2021-07-07
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM as a tool to study KatG from Mycobacterium tuberculosis
To Be Published
7A2I
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BU of 7a2i by Molmil
Cryo-EM structure of W107R KatG from M. tuberculosis
Descriptor: Catalase-peroxidase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Blundell, T.L, Chaplin, A.K, Munir, A.
Deposit date:2020-08-18
Release date:2021-01-27
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis.
Structure, 29, 2021

 

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