Author results

3MO0
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HUMAN G9A-LIKE (GLP, ALSO KNOWN AS EHMT1) IN COMPLEX WITH INHIBITOR E11
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Chang, Y., Horton, J.R., Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3MO2
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HUMAN G9A-LIKE (GLP, ALSO KNOWN AS EHMT1) IN COMPLEX WITH INHIBITOR E67
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3MO5
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HUMAN G9A-LIKE (GLP, ALSO KNOWN AS EHMT1) IN COMPLEX WITH INHIBITOR E72
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Cheng, X.
Deposit date:2010-04-22
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
J.Mol.Biol., 400, 2010
3SVM
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HUMAN MPP8 - HUMAN DNMT3AK47ME2 PEPTIDE
Descriptor:M-phase phosphoprotein 8, DNA (cytosine-5)-methyltransferase 3A
Authors:Chang, Y., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2011-07-12
Release date:2011-11-30
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
3SW9
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GLP (G9A-LIKE PROTEIN) SET DOMAIN IN COMPLEX WITH DNMT3AK44ME0 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase EHMT1, DNA (cytosine-5)-methyltransferase 3A, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2011-07-13
Release date:2011-12-07
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
3SWC
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GLP (G9A-LIKE PROTEIN) SET DOMAIN IN COMPLEX WITH DNMT3AK44ME2 PEPTIDE
Descriptor:Histone-lysine N-methyltransferase EHMT1, DNA (cytosine-5)-methyltransferase 3A, ZINC ION, ...
Authors:Chang, Y., Horton, J.R., Zhang, X., Cheng, X.
Deposit date:2011-07-13
Release date:2011-11-30
Method:X-RAY DIFFRACTION (2.332 Å)
Cite:MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a.
Nat Commun, 2, 2011
3FPD
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G9A-LIKE PROTEIN LYSINE METHYLTRANSFERASE INHIBITION BY BIX-01294
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Chang, Y., Zhang, X., Horton, J.R., Cheng, X.
Deposit date:2009-01-05
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.
Nat.Struct.Mol.Biol., 16, 2009
3OPT
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CRYSTAL STRUCTURE OF THE RPH1 CATALYTIC CORE WITH A-KETOGLUTARATE
Descriptor:DNA damage-responsive transcriptional repressor RPH1, 2-OXOGLUTARIC ACID, NICKEL (II) ION
Authors:Chang, Y., Wu, J., Tong, X., Zhou, J., Ding, J.
Deposit date:2010-09-02
Release date:2010-12-22
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
Biochem.J., 433, 2011
3OPW
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CRYSTAL STRUCTURE OF THE RPH1 CATALYTIC CORE
Descriptor:DNA damage-responsive transcriptional repressor RPH1
Authors:Chang, Y., Wu, J., Tong, X., Zhou, J., Ding, J.
Deposit date:2010-09-02
Release date:2010-12-22
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
Biochem.J., 433, 2011
3QO2
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STRUCTURAL INSIGHTS FOR MPP8 CHROMODOMAIN INTERACTION WITH HISTONE H3 LYSINE 9
Descriptor:M-phase phosphoprotein 8, Histone H3 peptide, 1,2-ETHANEDIOL
Authors:Chang, Y., Horton, J.R., Bedford, M.T., Zhang, X., Cheng, X.
Deposit date:2011-02-09
Release date:2011-04-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding.
J.Mol.Biol., 408, 2011
3QXY
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HUMAN SETD6 IN COMPLEX WITH RELA LYS310
Descriptor:N-lysine methyltransferase SETD6, Transcription factor p65, S-ADENOSYLMETHIONINE, ...
Authors:Chang, Y., Levy, D., Horton, J.R., Peng, J., Zhang, X., Gozani, O., Cheng, X.
Deposit date:2011-03-02
Release date:2011-05-25
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
Nucleic Acids Res., 39, 2011
3RC0
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HUMAN SETD6 IN COMPLEX WITH RELA LYS310 PEPTIDE
Descriptor:N-lysine methyltransferase SETD6, Transcription factor p65 peptide, 1,2-ETHANEDIOL, ...
Authors:Chang, Y., Levy, D., Horton, J.R., Peng, J., Zhang, X., Gozani, O., Cheng, X.
Deposit date:2011-03-30
Release date:2011-05-25
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
Nucleic Acids Res., 39, 2011
4PGR
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CRYSTAL STRUCTURE OF YETJ FROM BACILLUS SUBTILIS AT PH 8
Descriptor:Uncharacterized protein YetJ
Authors:Liu, Q., Chang, Y., Hendrickson, W.A., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2014-05-02
Release date:2014-06-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for a pH-sensitive calcium leak across membranes.
Science, 344, 2014
4PGS
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CRYSTAL STRUCTURE OF YETJ FROM BACILLUS SUBTILIS AT PH 6 BY SOAKING
Descriptor:Uncharacterized protein YetJ
Authors:Liu, Q., Chang, Y., Hendrickson, W.A., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2014-05-02
Release date:2014-06-04
Last modified:2014-06-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for a pH-sensitive calcium leak across membranes.
Science, 344, 2014
4PGU
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CRYSTAL STRUCTURE OF YETJ FROM BACILLUS SUBTILIS AT PH 7 BY SOAKING
Descriptor:Uncharacterized protein YetJ
Authors:Liu, Q., Chang, Y., Hendrickson, W.A., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2014-05-02
Release date:2014-06-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.401 Å)
Cite:Structural basis for a pH-sensitive calcium leak across membranes.
Science, 344, 2014
4PGV
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CRYSTAL STRUCTURE OF YETJ FROM BACILLUS SUBTILIS AT PH 8 BY BACK SOAKING
Descriptor:Uncharacterized protein YetJ
Authors:Liu, Q., Chang, Y., Hendrickson, W.A., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2014-05-02
Release date:2014-06-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural basis for a pH-sensitive calcium leak across membranes.
Science, 344, 2014
4PGW
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CRYSTAL STRUCTURE OF YETJ FROM BACILLUS SUBTILIS AT PH 6 BY PT-SAD
Descriptor:Uncharacterized protein YetJ, PLATINUM (II) ION
Authors:Liu, Q., Chang, Y., Hendrickson, W.A., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2014-05-02
Release date:2014-06-04
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for a pH-sensitive calcium leak across membranes.
Science, 344, 2014
2LJV
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SOLUTION STRUCTURE OF RHODOSTOMIN G50L MUTANT
Descriptor:Disintegrin rhodostomin
Authors:Chuang, W., Shiu, J., Chen, C., Chen, Y., Chang, Y., Huang, C.
Deposit date:2011-09-29
Release date:2012-10-03
Method:SOLUTION NMR
Cite:Design of Integrin AlphaVbeta3-Specific Disintegrin for Cancer Therapy
To be Published
2M75
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THE C-TERMINAL REGION OF DISINTEGRIN MODULATE ITS 3D CONFORMATION AND COOPERATE WITH RGD LOOP IN REGULATING RECOGNITIONS OF INTEGRINS
Descriptor:Zinc metalloproteinase/disintegrin
Authors:Chuang, W., Chang, Y., Shiu, J.
Deposit date:2013-04-18
Release date:2013-05-22
Method:SOLUTION NMR
Cite:The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins
To be Published
2M7F
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THE C-TERMINAL REGION OF DISINTEGRIN MODULATE ITS 3D CONFORMATION AND COOPERATE WITH RGD LOOP IN REGULATING INTEGRINS RECOGNITIONS
Descriptor:Zinc metalloproteinase/disintegrin
Authors:Chuang, W., Chang, Y.
Deposit date:2013-04-22
Release date:2013-05-22
Method:SOLUTION NMR
Cite:The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins
To be Published
2M7H
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THE C-TERMINAL REGION OF DISINTEGRIN MODULATE ITS 3D CONFORMATION AND COOPERATE WITH RGD LOOP IN REGULATING INTEGRIN ALPHA-IIB BETA-3 RECOGNITION
Descriptor:Zinc metalloproteinase/disintegrin
Authors:Chuang, W., Chang, Y.
Deposit date:2013-04-22
Release date:2013-05-22
Method:SOLUTION NMR
Cite:The C-terminal Region of Disintegrin Modulate its 3D Conformation and Cooperate with RGD Loop in Regulating Recognitions of Integrins
To be Published
4TKQ
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NATIVE-SAD PHASING FOR YETJ FROM BACILLUS SUBTILIS
Descriptor:Uncharacterized protein YetJ, CALCIUM ION, CHLORIDE ION
Authors:Liu, Q., Chang, Y., Hendrickson, W.A., New York Consortium on Membrane Protein Structure (NYCOMPS)
Deposit date:2014-05-27
Release date:2014-06-18
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.8025 Å)
Cite:Multi-crystal native SAD analysis at 6 keV.
Acta Crystallogr.,Sect.D, 70, 2014
3OS5
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SET7/9-DNMT1 K142ME1 COMPLEX
Descriptor:Histone-lysine N-methyltransferase SETD7, Dnmt1, BETA-MERCAPTOETHANOL, ...
Authors:Esteve, P.-O., Chang, Y., Samaranayake, M., Upadhyay, A.K., Horton, J.R., Feehery, G.R., Cheng, X., Pradhan, S.
Deposit date:2010-09-08
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.
Nat.Struct.Mol.Biol., 18, 2011
6NQ7
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CRYSTAL STRUCTURE OF YETJ FROM BACILLUS SUBTILIS CRYSTALLIZED IN LIPIDIC CUBIC PHASE
Descriptor:Uncharacterized protein YetJ, GADOLINIUM ATOM
Authors:Guo, G., Chang, Y., Liu, Q.
Deposit date:2019-01-19
Release date:2019-04-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ion and pH Sensitivity of a TMBIM Ca2+Channel.
Structure, 2019
6NQ8
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CRYSTAL STRUCTURE OF YETJ MUTANT FROM BACILLUS SUBTILIS - D171E
Descriptor:Uncharacterized protein YetJ
Authors:Guo, G., Chang, Y., Liu, Q.
Deposit date:2019-01-19
Release date:2019-04-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Ion and pH Sensitivity of a TMBIM Ca2+Channel.
Structure, 2019
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