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1YUY
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BU of 1yuy by Molmil
HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE GENOTYPE 2a
Descriptor: RNA-Dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-14
Release date:2005-03-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
1YV2
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BU of 1yv2 by Molmil
Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a
Descriptor: GLYCEROL, RNA dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-14
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors
J.Biol.Chem., 280, 2005
1YVZ
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BU of 1yvz by Molmil
Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor
Descriptor: 3-[(2,4-DICHLOROBENZOYL)(ISOPROPYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
1YVX
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BU of 1yvx by Molmil
Hepatitis C Virus RNA Polymerase Genotype 2a In Complex With Non- Nucleoside Analogue Inhibitor
Descriptor: 3-[ISOPROPYL(4-METHYLBENZOYL)AMINO]-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA dependent RNA polymerase, SULFATE ION
Authors:Biswal, B.K, Cherney, M.M, Wang, M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Nicolas, O, Bedard, J, James, M.N.G.
Deposit date:2005-02-16
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
J.Biol.Chem., 280, 2005
2D41
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BU of 2d41 by Molmil
X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor
Descriptor: 5'-ACETYL-4-{[(2,4-DIMETHYLPHENYL)SULFONYL]AMINO}-2,2'-BITHIOPHENE-5-CARBOXYLIC ACID, polyprotein
Authors:Biswal, B.K, Wang, M, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Bedard, J, James, M.N.G.
Deposit date:2005-10-05
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361, 2006
2D3Z
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BU of 2d3z by Molmil
X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with non-nucleoside analogue inhibitor
Descriptor: 5-(4-FLUOROPHENYL)-3-{[(4-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID, polyprotein
Authors:Biswal, B.K, Wang, M, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Bedard, J, James, M.N.G.
Deposit date:2005-10-04
Release date:2006-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361, 2006
2D3U
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BU of 2d3u by Molmil
X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor
Descriptor: 5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID, polyprotein
Authors:Biswal, B.K, Wang, M, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bilimoria, D, Bedard, J, James, M.N.G.
Deposit date:2005-10-02
Release date:2006-08-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361, 2006
1NHV
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BU of 1nhv by Molmil
Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor
Descriptor: (2S)-2-[(5-BENZOFURAN-2-YL-THIOPHEN-2-YLMETHYL)-(2,4-DICHLORO-BENZOYL)-AMINO]-3-PHENYL-PROPIONIC ACID, HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE
Authors:Wang, M, Ng, K.K.S, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bedard, J, Morin, N, Nguyen-Ba, N, Alaoui-Ismaili, M.H, Bethell, R.C, James, M.N.G.
Deposit date:2002-12-19
Release date:2003-03-18
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
1NHU
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BU of 1nhu by Molmil
Hepatitis C virus RNA polymerase in complex with non-nucleoside analogue inhibitor
Descriptor: (2S)-2-[(2,4-DICHLORO-BENZOYL)-(3-TRIFLUOROMETHYL-BENZYL)-AMINO]-3-PHENYL-PROPIONIC ACID, HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE
Authors:Wang, M, Ng, K.K.S, Cherney, M.M, Chan, L, Yannopoulos, C.G, Bedard, J, Morin, N, Nguyen-Ba, N, Alaoui-Ismaili, M.H, Bethell, R.C, James, M.N.G.
Deposit date:2002-12-19
Release date:2003-03-18
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-Nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase: Crystal Structures and Mechanism of Inhibition
J.Biol.Chem., 278, 2003
2K1Z
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BU of 2k1z by Molmil
Solution structure of Par-3 PDZ3
Descriptor: Partitioning-defective 3 homolog
Authors:Feng, W, Wu, H, Chan, L, Zhang, M.
Deposit date:2008-03-18
Release date:2008-06-10
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of Par-3 PDZ3
To be Published
2K20
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BU of 2k20 by Molmil
Solution structure of Par-3 PDZ3 in complex with PTEN peptide
Descriptor: Partitioning-defective 3 homolog, Protein tyrosine phosphatase and tensin homolog
Authors:Feng, W, Wu, H, Chan, L, Zhang, M.
Deposit date:2008-03-18
Release date:2008-06-10
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of Par-3 PDZ3 in complex with PTEN peptide
To be Published
4PZX
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BU of 4pzx by Molmil
Synthesis, Characterization and PK/PD Studies of a Series of Spirocyclic Pyranochromene BACE1 Inhibitors
Descriptor: (4R,4a'R,10a'R)-7'-(5-chloropyridin-3-yl)-3',4',4a',10a'-tetrahydro-1'H-spiro[1,3-oxazole-4,5'-pyrano[3,4-b]chromen]-2-amine, Beta-secretase 1, NICKEL (II) ION
Authors:Vigers, G.P.A.
Deposit date:2014-03-31
Release date:2014-05-14
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4PZW
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BU of 4pzw by Molmil
Synthesis, Characterization and PK/PD Studies of a Series of Spirocyclic Pyranochromene BACE1 Inhibitors
Descriptor: (4R,4a'S,10a'S)-7'-(5-chloropyridin-3-yl)-3',4',4a',10a'-tetrahydro-1'H-spiro[1,3-oxazole-4,5'-pyrano[3,4-b]chromen]-2-amine, Beta-secretase 1, NICKEL (II) ION
Authors:Vigers, G.P.A.
Deposit date:2014-03-31
Release date:2014-05-14
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
2KNP
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BU of 2knp by Molmil
Isolation and characterization of peptides from Momordica cochinchinensis seeds.
Descriptor: MCoCC-1
Authors:Daly, N.L, Chan, L.
Deposit date:2009-08-30
Release date:2009-11-10
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Isolation and characterization of peptides from Momordica cochinchinensis seeds.
J.Nat.Prod., 72, 2009
2M2Q
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BU of 2m2q by Molmil
Solution structure of MCh-1: A novel inhibitor cystine knot peptide from Momordica charantia
Descriptor: Inhibitor cystine knot peptide MCh-1
Authors:He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N.
Deposit date:2013-01-01
Release date:2013-11-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2M2R
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BU of 2m2r by Molmil
Solution structure of MCh-2: A novel inhibitor cystine knot peptide from Momordica charantia
Descriptor: Inhibitor cystine knot peptide MCh-2
Authors:He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N.
Deposit date:2013-01-01
Release date:2013-11-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Novel Inhibitor Cystine Knot Peptides from Momordica charantia.
Plos One, 8, 2013
2ZKU
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BU of 2zku by Molmil
Structure of hepatitis C virus NS5B polymerase in a new crystal form
Descriptor: ACETIC ACID, GLYCEROL, Genome polyprotein
Authors:Biswal, B.K.
Deposit date:2008-03-31
Release date:2009-04-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Hepatitis C Virus Ns5B Polymerase in a New Crystal Form: Insights Into Oligomerisation and Allosteric Nucleotide Binding Site
To be Published
2HXA
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BU of 2hxa by Molmil
Crystal structure of Cu(I) Azurin with the metal-binding loop sequence "CTFPGHSALM" replaced with "CSPHQGAGM", at pH3.5
Descriptor: Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007
2HX9
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BU of 2hx9 by Molmil
Crystal structure of Cu(I) Azurin with the metal-binding loop sequence "CTFPGHSALM" replaced with "CSPHQGAGM", at pH4
Descriptor: Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007
2HX7
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BU of 2hx7 by Molmil
Crystal structure of Cu(II) Azurin with the metal-binding loop sequence "CTFPGHSALM" replaced with "CSPHQGAGM"
Descriptor: Azurin, COPPER (II) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007
2HX8
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BU of 2hx8 by Molmil
Crystal structure of Cu(I) Azurin with the metal-binding loop sequence "CTFPGHSALM" replaced with "CSPHQGAGM", at pH5
Descriptor: Azurin, COPPER (I) ION
Authors:Banfield, M.J.
Deposit date:2006-08-03
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Engineering Copper Sites in Proteins: Loops Confer Native Structures and Properties to Chimeric Cupredoxins.
J.Am.Chem.Soc., 129, 2007

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