Author results

2VAN
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NUCLEOTIDYL TRANSFER MECHANISM OF MISMATCHED DNTP INCORPORATION BY DNA POLYMERASE B BY STRUCTURAL AND KINETIC ANALYSES
Descriptor:DNA POLYMERSE BETA
Authors:Chan, H., Chou, C., Tang, K., Niebuhr, M., Tung, C., Tsai, M.
Deposit date:2007-09-03
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mismatched Dntp Incorporation by DNA Polymerase Beta Does not Proceed Via Globally Different Conformational Pathways.
Nucleic Acids Res., 36, 2008
5DFM
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STRUCTURE OF TETRAHYMENA TELOMERASE P19 FUSED TO MBP
Descriptor:Maltose-binding periplasmic protein,Telomerase-associated protein 19, MALTOSE, SULFATE ION, ...
Authors:Chan, H., Cascio, D., Sawaya, M.R., Feigon, J.
Deposit date:2015-08-27
Release date:2015-10-28
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
Science, 350, 2015
5DFN
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STRUCTURE OF TETRAHYMENA TELOMERASE P45 C-TERMINAL DOMAIN
Descriptor:Telomerase associated protein p45
Authors:Chan, H., Cascio, D., Sawaya, M.R., Feigon, J.
Deposit date:2015-08-27
Release date:2015-10-28
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
Science, 350, 2015
2YB8
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CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH SU(Z)12
Descriptor:POLYCOMB PROTEIN SU(Z)12, PROBABLE HISTONE-BINDING PROTEIN CAF1, SULFATE ION
Authors:Schmitges, F.W., Prusty, A.B., Faty, M., Stutzer, A., Lingaraju, G.M., Aiwazian, J., Sack, R., Hess, D., Li, L., Zhou, S., Bunker, R.D., Wirth, U., Bouwmeester, T., Bauer, A., Ly-Hartig, N., Zhao, K., Chan, H., Gu, J., Gut, H., Fischle, W., Muller, J., Thoma, N.H.
Deposit date:2011-03-02
Release date:2011-05-18
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Histone Methylation by Prc2 is Inhibited by Active Chromatin Marks.
Mol.Cell, 42, 2011
2YBA
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CRYSTAL STRUCTURE OF NURF55 IN COMPLEX WITH HISTONE H3
Descriptor:PROBABLE HISTONE-BINDING PROTEIN CAF1, HISTONE H3
Authors:Schmitges, F.W., Prusty, A.B., Faty, M., Stutzer, A., Lingaraju, G.M., Aiwazian, J., Sack, R., Hess, D., Li, L., Zhou, S., Bunker, R.D., Wirth, U., Bouwmeester, T., Bauer, A., Ly-Hartig, N., Zhao, K., Chan, H., Gu, J., Gut, H., Fischle, W., Muller, J., Thoma, N.H.
Deposit date:2011-03-02
Release date:2011-05-11
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Histone Methylation by Prc2 is Inhibited by Active Chromatin Marks
Mol.Cell, 42, 2011
1C5L
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:thrombin, Hirudin, SODIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5M
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (COAGULATION FACTOR X)
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5N
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:Thrombin light chain, Thrombin heavy chain, Hirudin, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5O
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:Thrombin light chain, Thrombin heavy chain, Hirudin, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5P
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, MAGNESIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5Q
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, CHLORIDE ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5R
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CITRATE ANION, CALCIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5S
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, SULFATE ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5T
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5U
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, MAGNESIUM ION, ...
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5V
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (TRYPSIN), CALCIUM ION, MAGNESIUM ION
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5W
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5X
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5Y
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1C5Z
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STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR
Descriptor:PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR), CITRATE ANION, BENZAMIDINE
Authors:Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.
Deposit date:1999-12-22
Release date:2000-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Chem.Biol., 7, 2000
1O5A
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DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Urokinase-type plasminogen activator, 3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1'-BIPHENYL-2-OLATE, CITRIC ACID
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344, 2004
1O5B
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DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Urokinase-type plasminogen activator, 4-IODOBENZO[B]THIOPHENE-2-CARBOXAMIDINE, CITRIC ACID
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344, 2004
1O5C
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DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Urokinase-type plasminogen activator, 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE, CITRIC ACID
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)
J.Mol.Biol., 344, 2004
1O5D
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DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Coagulation factor VII, Tissue factor, 2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
1O5E
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DISSECTING AND DESIGNING INHIBITOR SELECTIVITY DETERMINANTS AT THE S1 SITE USING AN ARTIFICIAL ALA190 PROTEASE (ALA190 UPA)
Descriptor:Serine protease hepsin, 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE
Authors:Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., Verner, E., Mackman, R.L., Young, W.B., Sprengeler, P.A., Chan, H., Mortara, K., Janc, J.W., McGrath, M.E.
Deposit date:2003-09-09
Release date:2004-09-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA).
J.Mol.Biol., 344, 2004
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