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2AQX
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BU of 2aqx by Molmil
Crystal Structure of the Catalytic and CaM-Binding domains of Inositol 1,4,5-Trisphosphate 3-Kinase B
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PREDICTED: inositol 1,4,5-trisphosphate 3-kinase B
Authors:Chamberlain, P.P, Sandberg, M.L, Sauer, K, Cooke, M.P, Lesley, S.A, Spraggon, G.
Deposit date:2005-08-18
Release date:2005-12-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into enzyme regulation for inositol 1,4,5-trisphosphate 3-kinase B
Biochemistry, 44, 2005
4TZU
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BU of 4tzu by Molmil
Crystal Structure of Murine Cereblon in Complex with Pomalidomide
Descriptor: Protein cereblon, S-Pomalidomide, SULFATE ION, ...
Authors:Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
4TZC
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BU of 4tzc by Molmil
Crystal Structure of Murine Cereblon in Complex with Thalidomide
Descriptor: Protein cereblon, S-Thalidomide, SULFATE ION, ...
Authors:Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
4TZ4
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BU of 4tz4 by Molmil
Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ...
Authors:Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M.
Deposit date:2014-07-09
Release date:2014-08-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
2Q7D
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BU of 2q7d by Molmil
Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+
Descriptor: Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Chamberlain, P.P, Lesley, S.A, Spraggon, G.
Deposit date:2007-06-06
Release date:2007-07-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
2QB5
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BU of 2qb5 by Molmil
Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-Kinase (ITPK1) in Complex with ADP and Mn2+
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, ...
Authors:Chamberlain, P.P, Lesley, S.A, Spraggon, G.
Deposit date:2007-06-15
Release date:2007-07-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Integration of inositol phosphate signaling pathways via human ITPK1.
J.Biol.Chem., 282, 2007
5HXB
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BU of 5hxb by Molmil
Cereblon in complex with DDB1, CC-885, and GSPT1
Descriptor: 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ...
Authors:Chamberlain, P.P, Matyskiela, M, Pagarigan, B.
Deposit date:2016-01-30
Release date:2016-06-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature, 535, 2016
3DOK
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BU of 3dok by Molmil
Crystal structure of K103N mutant HIV-1 reverse transcriptase in complex with GW678248.
Descriptor: 2-{4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenoxy}-N-(2-methyl-4-sulfamoylphenyl)acetamide, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ...
Authors:Chamberlain, P.P, Ren, J, Stammers, D.K.
Deposit date:2008-07-04
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J.Med.Chem., 51, 2008
3DOL
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BU of 3dol by Molmil
Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with GW695634.
Descriptor: N-({4-[({4-chloro-2-[(3-chloro-5-cyanophenyl)carbonyl]phenoxy}acetyl)amino]-3-methylphenyl}sulfonyl)propanamide, PHOSPHATE ION, Reverse transcriptase/ribonuclease H, ...
Authors:Chamberlain, P.P, Ren, J, Stammers, D.K.
Deposit date:2008-07-04
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.
J.Med.Chem., 51, 2008
1LWE
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BU of 1lwe by Molmil
CRYSTAL STRUCTURE OF M41L/T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMN) IN COMPLEX WITH NEVIRAPINE
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION
Authors:Ren, J, Chamberlain, P.P, Nichols, C.E, Douglas, L, Stuart, D.I, Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWC
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BU of 1lwc by Molmil
CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION
Authors:Ren, J, Chamberlain, P.P, Nichols, C.E, Douglas, L, Stuart, D.I, Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LW2
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BU of 1lw2 by Molmil
CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 1051U91
Descriptor: 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE, HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION
Authors:Ren, J, Chamberlain, P.P, Nichols, C.E, Douglas, L, Stuart, D.I, Stammers, D.K.
Deposit date:2002-05-30
Release date:2002-10-30
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LWF
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BU of 1lwf by Molmil
CRYSTAL STRUCTURE OF A MUTANT HIV-1 REVERSE TRANSCRIPTASE (RTMQ+M184V: M41L/D67N/K70R/M184V/T215Y) IN COMPLEX WITH NEVIRAPINE
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 REVERSE TRANSCRIPTASE
Authors:Ren, J, Chamberlain, P.P, Nichols, C.E, Douglas, L, Stuart, D.I, Stammers, D.K.
Deposit date:2002-05-31
Release date:2002-10-30
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
1LW0
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BU of 1lw0 by Molmil
CRYSTAL STRUCTURE OF T215Y MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION
Authors:Ren, J, Chamberlain, P.P, Nichols, C.E, Douglas, L, Stuart, D.I, Stammers, D.K.
Deposit date:2002-05-30
Release date:2002-10-30
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.
J.Virol., 76, 2002
6UML
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BU of 6uml by Molmil
Structural Basis for Thalidomide Teratogenicity Revealed by the Cereblon-DDB1-SALL4-Pomalidomide Complex
Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ...
Authors:Clayton, T.L, Matyskiela, M.E, Pagarigan, B.E, Tran, E.T, Chamberlain, P.P.
Deposit date:2019-10-09
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex.
Nat.Struct.Mol.Biol., 27, 2020
6B4W
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BU of 6b4w by Molmil
TTK in Complex with Inhibitor
Descriptor: 4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide, CACODYLATE ION, Dual specificity protein kinase TTK
Authors:Delker, S, Chamberlain, P.P.
Deposit date:2017-09-27
Release date:2017-10-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.
J. Med. Chem., 60, 2017
1S1T
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BU of 1s1t by Molmil
Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
Descriptor: 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE, PHOSPHATE ION, Reverse transcriptase
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1X
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BU of 1s1x by Molmil
Crystal structure of V108I mutant HIV-1 reverse transcriptase in complex with nevirapine
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, Reverse transcriptase
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1V
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BU of 1s1v by Molmil
Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with TNK-651
Descriptor: 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL, Reverse transcriptase
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1W
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BU of 1s1w by Molmil
Crystal structure of V106A mutant HIV-1 reverse transcriptase in complex with UC-781
Descriptor: 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE, Reverse transcriptase
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1U
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BU of 1s1u by Molmil
Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with nevirapine
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, Reverse transcriptase
Authors:Ren, J, Nichols, C.E, Chamberlain, P.P, Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
2HNY
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BU of 2hny by Molmil
Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ren, J, Nichols, C.E, Stamp, A, Chamberlain, P.P, Stammers, D.K.
Deposit date:2006-07-13
Release date:2006-09-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Febs J., 273, 2006
2HND
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BU of 2hnd by Molmil
Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
Descriptor: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ren, J, Nichols, C.E, Stamp, A, Chamberlain, P.P, Stammers, D.K.
Deposit date:2006-07-12
Release date:2006-09-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Febs J., 273, 2006
2HNZ
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BU of 2hnz by Molmil
Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2
Descriptor: 1-[2-(4-ETHOXY-3-FLUOROPYRIDIN-2-YL)ETHYL]-3-(5-METHYLPYRIDIN-2-YL)THIOUREA, PHOSPHATE ION, Reverse transcriptase/ribonuclease H
Authors:Ren, J, Nichols, C.E, Stamp, A, Chamberlain, P.P, Stammers, D.K.
Deposit date:2006-07-13
Release date:2006-09-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Febs J., 273, 2006
1MU2
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BU of 1mu2 by Molmil
CRYSTAL STRUCTURE OF HIV-2 REVERSE TRANSCRIPTASE
Descriptor: GLYCEROL, HIV-2 RT, SULFATE ION
Authors:Ren, J, Bird, L.E, Chamberlain, P.P, Stewart-Jones, G.B, Stuart, D.I, Stammers, D.K.
Deposit date:2002-09-23
Release date:2002-10-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of HIV-2 reverse transcriptase at 2.35-A resolution and the mechanism of resistance to non-nucleoside inhibitors
Proc.Natl.Acad.Sci.USA, 99, 2002

 

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